Abstract: The present disclosure relates to recombinant fusion proteins comprising an extracellular domain of the human angiotensin-converting enzyme 2 (ACE2), optionally having altered amino acid residues that result in increased binding affinity for the S1 spike protein of SARS-CoV-2, linked to a human immunoglobulin Fc region, that can extend the protein half-life (T1/2) and/or the duration of action as a decoy receptor, and compositions and methods of use of these fusion proteins.

Abstract: An in situ low-power wireless measurement apparatus and method suitable for reporting a soil moisture profile at various zones.

Abstract: An in situ ultra-low power contactless measurement apparatus and method suitable for micro-electronics in big data applications for continuously reporting a soil moisture profile at various zones.

Abstract: A terminal crimping device includes crimp tooling comprising an anvil and a ram movable toward the anvil with a crimp zone being defined between the anvil and the ram configured to receive a wire and a terminal configured to be crimped to the wire by the crimp tooling. An ultrasonic transmitting transducer is coupled to at least one of the anvil and the ram that transmits acoustic signals through the wire and terminal. A filter is provided on at least one of the anvil and the ram in the path of the acoustic signals that affects the acoustic signals.

Abstract: An in situ ultra-low power contactless measurement apparatus and method suitable for micro-electronics in big data applications for continuously reporting a soil moisture profile at various zones.

Abstract: Methods and materials providing a route for the use of transgenic plants as bio-factories to produce therapeutic miRNAs are described. The plants can be ingestible and can be used to deliver to a subject in need thereof a therapeutic miRNA by ingestion of the bioengineered plant tissue that carries an exogenous genetic sequence for the therapeutic miRNA. The therapeutic miRNA can be useful in treating a disease state such as cancer. The therapeutic miRNA can be a mammalian tumor suppressor miRNA.

Abstract: A terminal crimping machine includes an applicator having a movable ram and an anvil. The anvil is located in a crimping zone and configured to receive a terminal thereon. The ram has crimp tooling that is configured to crimp the terminal on the anvil to a wire during a crimp stroke of the ram. An image acquisition device is positioned to acquire at least one image of the crimping zone. A display device is configured to display the at least one acquired image.

Abstract: A terminal crimping device includes crimp tooling defining a crimp zone configured to receive a wire and a terminal. The terminal is configured to be crimped to the wire by the tooling during a crimp stroke of the crimp tooling to form a crimped terminal. The crimp tooling includes an ultrasound module ultrasonically coupled to the crimp tooling and the wire and the crimped terminal when present. The ultrasound module transmits acoustic signals through the crimped terminal and the wire. The ultrasound module also receives echo acoustic signals being reflected back to the ultrasound module. The ultrasound module generates echo signals based on the echo acoustic signals. The terminal crimping device also includes a crimp quality module that receives the echo signals from the ultrasound module and determines a crimp height of the crimped terminal based on the reflected echo acoustic signals received by the ultrasound module.

Abstract: A post-crimp inspection device includes first and second arms with an inspection zone being defined between the first and second arms and configured to receive a crimped terminal. At least one of the first and second arms is movable toward the crimped terminal during a testing phase. An ultrasonic transducer is coupled to the first arm. The ultrasonic transducer transmits acoustic signals toward the crimped terminal. A compliant member is positioned between the ultrasonic transducer and the crimped terminal. The ultrasonic transducer is ultrasonically coupled to the crimped terminal via the compliant member. The compliant member may conform to a contour of the terminal. The compliant member may receive, and be ultrasonically coupled to, crimped terminals that are crimped using different crimp tooling.

Abstract: A terminal crimping device includes crimp tooling comprising an anvil and a ram movable toward the anvil with a crimp zone being defined between the anvil and the ram configured to receive a wire and a terminal configured to be crimped to the wire by the crimp tooling. An ultrasonic transmitting transducer is coupled to at least one of the anvil and the ram that transmits acoustic signals through the wire and terminal.

Abstract: A terminal crimping machine includes an applicator having a movable ram and an anvil. The anvil is located in a crimping zone and configured to receive a terminal thereon. The ram has crimp tooling that is configured to crimp the terminal on the anvil to a wire during a crimp stroke of the ram. An image acquisition device is positioned to acquire at least one image of the crimping zone. A display device is configured to display the at least one acquired image.

Abstract: A system and method for monitoring a status of a medical instrument is provided. Using an input peripheral associated with a computer terminal, a code associated with the medical instrument to be subjected to a cleaning operation after a previous use of the medical instrument is received. A timer for monitoring a duration of the cleaning operation is initiated. In response to completion of the cleaning operation determined based on the timer, a status of the medical instrument in an electronic record associated with the medial instrument stored in a non-transitory computer-readable medium is updated to indicate that the medical instrument has been cleaned. An indication that the cleaning operation being performed on the medical instrument is complete is then issued.

Abstract: A telephone answering system (100) and method (200) that permits a user to immediately generate a customized playback message in response to an incoming call without having to actually answer the call. The system (100) can include a ring detector (104), a command interface (114), a controller (110) and a telephone network interface (102). In response to an incoming call, the ring detector (104) alerts the called party and causes the controller (110) to activate the command interface (114). The command interface (114) is activated for a predetermined time while the call is still ringing. While activated, the called party can select or enter a playback message. The playback message can be a pre-recorded audio message stored within the device, or a voice message spoken by the called party during the activation period. After the playback message is selected by the called party, the telephone system (100) answers the incoming call and automatically plays the customized message to the calling party.

Abstract: The immunoadhesions of the present invention are useful in treating rhinovirus infections. The immunoadhesions contain a chimeric ICAM molecule and may optionally also contain J chain and secretory compounds. The chimeric ICAM molecule is a fusion protein that has a rhinovirus receptor protein linked to an immunoglobulin protein. This invention also includes the greatly increased and improved method of producing immunoadhesions in plants. Each of the components of an immunoadhesin is produced in a plant cell and thereby assembles within the plant cell. This method of producing the immunoadhesions of the present invention results in the efficient and economic production of these molecules. The present invention also contemplates the production of immunoadhesions in a variety of eukaryotic cells including plants and mammalian cells. The immunoadhesions of the present invention are useful as a therapeutic against the common cold in humans which is caused by rhinoviruses.

Abstract: A system and method for monitoring a status of a medical instrument is provided. Using an input peripheral associated with a computer terminal, a code associated with the medical instrument to be subjected to a cleaning operation after a previous use of the medical instrument is received. A timer for monitoring a duration of the cleaning operation is initiated. In response to completion of the cleaning operation determined based on the timer, a status of the medical instrument in an electronic record associated with the medial instrument stored in a non-transitory computer-readable medium is updated to indicate that the medical instrument has been cleaned. An indication that the cleaning operation being performed on the medical instrument is complete is then issued.

Abstract: Provided are a method and system for tracking a patient at a medical facility. Tracking the patient includes, using a computer comprising an input peripheral manipulated by a user, receiving a first location of the patient within the medical facility identified by the user via the input peripheral. The first location is displayed on a display device operatively connected to the computer, the first location being identified by a graphical marker representing the first location where the patient can be found. In response to a user interaction with the input peripheral, a second location of the patient is received, indicating movement of the patient from the first location to the second, different location. In response to receiving the second location, the graphical marker on the display device operatively connected to the computer is moved to identify the second location where the patient can be found after being moved.

Abstract: A method of managing information related to immunotherapy treatment in a computer system is provided. The computer system includes an input peripheral system for reading a computer-readable code and inputting the computer-readable code into the computer system. An antigen having a predetermined concentration is associated with a master code that is computer readable to at least identify the antigen and the concentration of the antigen associated with the master code. An antigen recipe to be administered to the patient during immunotherapy treatment is associated with an antigen recipe code that is computer readable to identify each antigen included in the antigen recipe that is to be administered to the patient. In response to receiving the master code read by the input peripheral system in communication with the computer system, the antigen and the concentration of the antigen are associated with the antigen recipe code.

Abstract: A door has a core that includes a porous layer having a thickness and two opposing major surfaces. In one construction, the core also includes three fire-retardant layers, and two of the fire-retardant layers are separated by the porous layer. The porous layer and the fire-retardant layers are coupled together. Other constructions include one or more fire-retardant layers in balanced or unbalanced placement around the porous layer.

Abstract: The present disclosure relates to applicator counters and assemblies for counting, recording and transmitting cycles of machines, tools and the like. An applicator counter assembly for operative association with an applicator or the like is provided. The applicator counter assembly includes an applicator counter for counting, recording and transmitting cycles of the applicator. The applicator counter includes a magnetically responsive switch capable of being actuated in response to a magnetic force, whereby the applicator counter registers a count for each actuation of the switch.

Abstract: The immunoadhesions of the present invention are useful in treating rhinovirus infections. The immunoadhesions contain a chimeric ICAM molecule and may optionally also contain J chain and secretory compounds. The chimeric ICAM molecule is a fusion protein that has a rhinovirus receptor protein linked to an immunoglobulin protein. This invention also includes the greatly increased and improved method of producing immunoadhesions in plants. Each of the components of an immunoadhesin is produced in a plant cell and thereby assembles within the plant cell. This method of producing the immunoadhesions of the present invention results in the efficient and economic production of these molecules. The present invention also contemplates the production of immunoadhesions in a variety of eukaryotic cells including plants and mammalian cells. The immunoadhesions of the present invention are useful as a therapeutic against the common cold in humans which is caused by rhinoviruses.