Patents by Inventor Keith A. Moulton
Keith A. Moulton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11087460Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.Type: GrantFiled: November 30, 2018Date of Patent: August 10, 2021Assignee: ELUCID BIOIMAGING INC.Inventors: Andrew J. Buckler, Kjell Johnson, Xiaonan Ma, Keith A. Moulton, Mark A. Buckler, Vladimir Valtchinov, David S. Paik
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Patent number: 11071501Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.Type: GrantFiled: November 28, 2018Date of Patent: July 27, 2021Assignee: ELUCID BIOIWAGING INC.Inventors: Andrew J. Buckler, Kjell Johnson, Xiaonan Ma, Keith A. Moulton, Mark A. Buckler, Vladimir Valtchinov, David S. Paik
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Patent number: 11034929Abstract: Aspects of the present invention relate to an automated cell culture instrument and to methods for operating such an instrument. In one aspect, the cell culture instrument includes a computing unit and a plurality of electrically controllable resources (e.g., sensors, actuators, etc.). The computing unit receives a protocol, schedules the resources so as to execute the protocol, and operates the resources as scheduled or in response to so as to provide an improved environment for cell culture growth. The computing unit may simulate protocol execution in connection with the scheduling or execution of the protocol.Type: GrantFiled: November 18, 2016Date of Patent: June 15, 2021Assignee: Thrive Bioscience, Inc.Inventors: Howard Cannon, Keith Moulton
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Patent number: 10755810Abstract: Methods and systems are disclosed for structuring and using information pertinent to in vivo biomarkers, specifically quantitative imaging biomarkers, using semantic web technology for personalized medicine and discovery science. It supports the development and application of statistical evidence at a level of granularity and sophistication more closely tied to the complexity of the disease itself and its underlying biology, including technology linking multiple biological scales, than has previously been eedisclosed. It provides data and computational services to analyze quantitative imaging and non-imaging data, coupled with multi-scale modeling to elucidate pre-symptomatic and clinical disease processes. It may be used to assess technical or analytical performance for its own sake and/or to further annotate the quantitative analysis.Type: GrantFiled: August 15, 2016Date of Patent: August 25, 2020Assignee: ELUCID BIOIMAGING INC.Inventors: Andrew J. Buckler, Keith A. Moulton, Mary Buckler, Larry Martell, David S. Paik, Xiaonan Ma, Samantha St. Pierre
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Patent number: 10740880Abstract: The present disclosure provides for improved image analysis via novel deblurring and segmentation techniques of image data. These techniques advantageously account for and incorporate segmentation of biological analytes into a deblurring process for an image. Thus, the deblurring of the image may advantageously be optimized for enabling identification and quantitative analysis of one or more biological analytes based on underlying biological models for those analytes. The techniques described herein provide for significant improvements in the image deblurring and segmentation process which reduces signal noise and improves the accuracy of the image. In particular, the system and methods described herein advantageously utilize unique optimization and tissue characteristics image models which are informed by the underlying biology being analyzed, (for example by a biological model for the analytes). This provides for targeted deblurring and segmentation which is optimized for the applied image analytics.Type: GrantFiled: January 18, 2018Date of Patent: August 11, 2020Assignee: ELUCID BIOIMAGING INC.Inventors: David S. Paik, Andrew J. Buckler, Kjell Johnson, Xiaonan Ma, Keith A. Moulton
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Publication number: 20190244347Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.Type: ApplicationFiled: November 28, 2018Publication date: August 8, 2019Applicant: Elucid Bioimaging Inc.Inventors: Andrew J. Buckler, Kjell Johnson, Xiaonan Ma, Keith A. Moulton, Mark A. Buckler, Vladimir Valtchinov, David S. Paik
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Publication number: 20190244348Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.Type: ApplicationFiled: November 30, 2018Publication date: August 8, 2019Applicant: Elucid Bioimaging Inc.Inventors: Andrew J. Buckler, Kjell Johnson, Xiaonan Ma, Keith A. Moulton, Mark A. Buckler, Vladimir Valtchinov, David S. Paik
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Publication number: 20190180438Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.Type: ApplicationFiled: November 28, 2018Publication date: June 13, 2019Applicant: Elucid Bioimaging Inc.Inventors: Andrew J. Buckler, Kjell Johnson, Xiaonan Ma, Keith A. Moulton, Mark A. Buckler, Vladimir Valtchinov, David S. Paik
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Publication number: 20190180153Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.Type: ApplicationFiled: November 28, 2018Publication date: June 13, 2019Applicant: Elucid Bioimaging Inc.Inventors: Andrew J. Buckler, Kjell Johnson, Xiaonan Ma, Keith A. Moulton, Mark A. Buckler, Vladimir Valtchinov, David S. Paik
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Publication number: 20190172197Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.Type: ApplicationFiled: November 28, 2018Publication date: June 6, 2019Applicant: Elucid Bioimaging Inc.Inventors: Andrew J. Buckler, Kjell Johnson, Xiaonan Ma, Keith A. Moulton, Mark A. Buckler, Vladimir Valtchinov, David S. Paik
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Publication number: 20190159737Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.Type: ApplicationFiled: November 28, 2018Publication date: May 30, 2019Applicant: Elucid Bioimaging Inc.Inventors: Andrew J. Buckler, Kjell Johnson, Xiaonan Ma, Keith A. Moulton, Mark A. Buckler, Vladimir Valtchinov, David S. Paik
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Patent number: 10176408Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.Type: GrantFiled: December 4, 2015Date of Patent: January 8, 2019Assignee: Elucid Bioimaging Inc.Inventors: David S. Paik, Andrew J. Buckler, Kjell Johnson, Xiaonan Ma, Keith A. Moulton
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Publication number: 20180330477Abstract: The present disclosure provides for improved image analysis via novel deblurring and segmentation techniques of image data. These techniques advantageously account for and incorporate segmentation of biological analytes into a deblurring process for an image. Thus, the deblurring of the image may advantageously be optimized for enabling identification and quantitative analysis of one or more biological analytes based on underlying biological models for those analytes. The techniques described herein provide for significant improvements in the image deblurring and segmentation process which reduces signal noise and improves the accuracy of the image. In particular, the system and methods described herein advantageously utilize unique optimization and tissue characteristics image models which are informed by the underlying biology being analyzed, (for example by a biological model for the analytes). This provides for targeted deblurring and segmentation which is optimized for the applied image analytics.Type: ApplicationFiled: January 18, 2018Publication date: November 15, 2018Inventors: David S. Paik, Andrew J. Buckler, Kjell Johnson, Xiaonan Ma, Keith A. Moulton
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Publication number: 20180327708Abstract: Aspects of the present invention relate to an automated cell culture instrument and to methods for operating such an instrument. In one aspect, the cell culture instrument includes a computing unit and a plurality of electrically controllable resources (e.g., sensors, actuators, etc.). The computing unit receives a protocol, schedules the resources so as to execute the protocol, and operates the resources as scheduled or in response to so as to provide an improved environment for cell culture growth. The computing unit may simulate protocol execution in connection with the scheduling or execution of the protocol.Type: ApplicationFiled: November 18, 2016Publication date: November 15, 2018Inventors: Howard Cannon, Keith Moulton
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Publication number: 20170046484Abstract: Methods and systems for making image-derived information available by performing analyses with semantic annotations accessible using semantic web technology for personalized medicine and discovery science are disclosed. Individual cases are identified according to an identification scheme. Targets for image analysis for each case are characterized in order to support tracking of a given anatomy, suspected pathology, confirmed pathology, or medical intervention at one or more timepoints. Access information to one or more medical images of each target at each one of the one or more timepoints is provided and stored. One or more levels of image-derived analysis is obtained and stored, the image derived analysis including at least one of imaging features, measured quantities, phenotypic descriptions, or predictions relative to said one case.Type: ApplicationFiled: August 15, 2016Publication date: February 16, 2017Inventors: Andrew J. Buckler, Keith A. Moulton, Mary Buckler, Larry Martell, David S. Paik, Xiaonan Ma, Samantha St. Pierre
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Publication number: 20170046839Abstract: Systems and methods for analyzing pathologies utilizing quantitative imaging are presented herein. Advantageously, the systems and methods of the present disclosure utilize a hierarchical analytics framework that identifies and quantify biological properties/analytes from imaging data and then identifies and characterizes one or more pathologies based on the quantified biological properties/analytes. This hierarchical approach of using imaging to examine underlying biology as an intermediary to assessing pathology provides many analytic and processing advantages over systems and methods that are configured to directly determine and characterize pathology from underlying imaging data.Type: ApplicationFiled: December 4, 2015Publication date: February 16, 2017Applicant: Elucid Bioimaging Inc.Inventors: David S. Paik, Andrew J. Buckler, Kjell Johnson, Xiaonan Ma, Keith A. Moulton
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Publication number: 20100034444Abstract: Image processing for certain sequencing technologies requires data processing algorithms that provide fast sequence detection with low error rates. Methods and apparatus for performing image analysis for identifying nucleotide incorporations includes performing an image segmentation procedure on a plurality of data sets to identify sample objects and to create segmented data sets for each of the data sets. Each data set represents a sample image that includes a plurality of pixel locations and intensity data associated with each of the pixel locations. The segmented data sets represent identified sample objects for each one of the sample image data sets. An image registration procedure is performed on the segmented data sets to align the identified sample objects and to create data representative of the aligned identified sample objects. A strand formation procedure is then performed on the data representative of the aligned identified sample objects to identify nucleotide incorporations.Type: ApplicationFiled: August 7, 2008Publication date: February 11, 2010Applicant: Helicos Biosciences CorporationInventors: John Emhoff, John Healy, Keith Moulton
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Publication number: 20030182052Abstract: An Integrated Routing/Mapping Information System (IRMIS) links desktop personal computer cartographic applications to one or more handheld organizer, personal digital assistant (PDA) or “palmtop” devices. Such devices may be optionally equipped with, or connected to, portable Global Positioning System (GPS) or equivalent position sensing device. Desktop application facilitates user selection of areas, starts, stops, destinations, maps and/or point and/or route information. It optionally includes supplemental online information, preferably for transfer to the PDA or equivalent device. Users' options include route information, area, and route maps. Maps and related route information are configured with differential detail and levels of magnitude. Used in the field, in conjunction with GPS receiver, the PDA device is configured to display directions, text and map formats, the user's current position, heading, speed, elevation, and so forth.Type: ApplicationFiled: October 30, 2001Publication date: September 25, 2003Inventors: David M. DeLorme, Keith A. Gray, Gordon Autry, Keith A. Moulton
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Patent number: 6321158Abstract: An Integrated Routing/Mapping Information System (IRMIS) links desktop personal computer cartographic applications to one or more handheld organizer, personal digital assistant (PDA) or “palmtop” devices. Such devices may be optionally equipped with, or connected to, portable Global Positioning System (GPS) or equivalent position sensing device. Desktop application facilitates user selection of areas, starts, stops, destinations, maps and/or point and/or route information. It optionally includes supplemental online information, preferably for transfer to the PDA or equivalent device. Users' options include route information, area, and route maps. Maps and related route information are configured with differential detail and levels of magnitude. Used in the field, in conjunction with GPS receiver, the PDA device is configured to display directions, text and map formats, the user's current position, heading, speed, elevation, and so forth.Type: GrantFiled: August 31, 1998Date of Patent: November 20, 2001Assignee: DeLorme Publishing CompanyInventors: David M. DeLorme, Keith A. Gray, Gordon Autry, Keith A. Moulton