Patents by Inventor Keith A. Walker

Keith A. Walker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11952577
    Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: April 9, 2024
    Assignee: NUCELIS LLC
    Inventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham
  • Publication number: 20220298525
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.
    Type: Application
    Filed: September 7, 2021
    Publication date: September 22, 2022
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Gregory F.W. Gocal, Peter R. Beetham, Aura Estela Gonzalez Schopke, Sarah Dumm, James Pearce, Christian Schopke, Keith A. Walker
  • Patent number: 11160224
    Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide.
    Type: Grant
    Filed: July 30, 2018
    Date of Patent: November 2, 2021
    Assignee: CIBUS US LLC
    Inventors: Peter R. Beetham, Patricia L. Avissar, Keith A. Walker, Richard A. Metz
  • Patent number: 11111500
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: September 7, 2021
    Assignees: CIBUS US LLC, CIBUS Europe B.V.
    Inventors: Gregory F. W. Gocal, Peter R. Beetham, Aura Estela Gonzalez Schopke, Sarah Dumm, James Pearce, Christian Schopke, Keith A. Walker
  • Patent number: 10815495
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the allene oxide synthase 2 gene (i.e., AOS2). In some embodiments the disclosure relates to plants that are pathogen resistant.
    Type: Grant
    Filed: October 16, 2017
    Date of Patent: October 27, 2020
    Assignees: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Uvini Gunawardena, Gregory F. W. Gocal, Peter R. Beetham, Keith A. Walker
  • Publication number: 20200123563
    Abstract: Provided are mutated acetohydroxyacid synthase (AHAS) nucleic acids and the proteins encoded by the mutated nucleic acids. Also provided are canola plants, cells, and seeds comprising the mutated genes.
    Type: Application
    Filed: December 27, 2019
    Publication date: April 23, 2020
    Applicant: Cibus US LLC
    Inventors: Christian Schopke, Gregory F. W. Gocal, Keith A. Walker, Peter R. Beetham
  • Publication number: 20180355327
    Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide.
    Type: Application
    Filed: July 30, 2018
    Publication date: December 13, 2018
    Applicant: CIBUS US LLC
    Inventors: PETER R. BEETHAM, Patricia L. Avissar, Keith A. Walker, Richard A. Metz
  • Publication number: 20180327773
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.
    Type: Application
    Filed: July 23, 2018
    Publication date: November 15, 2018
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Gregory F.W. Gocal, Peter R. Beetham, Aura Estela Gonzalez Schopke, Sarah Dumm, James Pearce, Christian Schopke, Keith A. Walker
  • Patent number: 10100334
    Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically altered yeast and uses therefore. In some aspects and embodiments, the genetically altered yeast produce isoprenoids, preferably squalene. The genetically altered yeast may have alterations in the expression or activity of enzymes involved in squalene production, for example, acetyl-CoA carboxylase (or “ACCase”), HMG-CoA reductase, squalene epoxidase, and squalene synthase. One or more genes of a genetically altered yeast may be modified by gene repair oligonucleobases. Also are provided methods of producing squalene using a genetically altered yeast. The invention also provides squalene produced by genetically altered yeast.
    Type: Grant
    Filed: May 22, 2009
    Date of Patent: October 16, 2018
    Assignee: NUCELIS INC.
    Inventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham
  • Patent number: 10035991
    Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide.
    Type: Grant
    Filed: November 16, 2007
    Date of Patent: July 31, 2018
    Assignee: CIBUS US LLC
    Inventors: Peter R. Beetham, Patricia L. Avissar, Keith A. Walker, Richard A. Metz
  • Publication number: 20180051296
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the allene oxide synthase 2 gene (i.e., AOS2). In some embodiments the disclosure relates to plants that are pathogen resistant.
    Type: Application
    Filed: October 16, 2017
    Publication date: February 22, 2018
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Uvini GUNAWARDENA, Gregory F.W. GOCAL, Peter R. BEETHAM, Keith A. WALKER
  • Patent number: 9790515
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the allene oxide synthase 2 gene (i.e., AOS2). In some embodiments the disclosure relates to plants that are pathogen resistant.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: October 17, 2017
    Assignees: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Uvini Gunawardena, Gregory F. W. Gocal, Peter R. Beetham, Keith A. Walker
  • Publication number: 20170145429
    Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.
    Type: Application
    Filed: January 9, 2017
    Publication date: May 25, 2017
    Inventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham
  • Patent number: 9540662
    Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.
    Type: Grant
    Filed: June 25, 2013
    Date of Patent: January 10, 2017
    Assignee: NUCELIS LLC
    Inventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham
  • Publication number: 20160145638
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the allene oxide synthase 2 gene (i.e., AOS2). In some embodiments the disclosure relates to plants that are pathogen resistant.
    Type: Application
    Filed: March 14, 2014
    Publication date: May 26, 2016
    Applicants: CIBUS US LLC, CIBUS EUROPE B.V.
    Inventors: Uvini GUNAWARDENA, Gregory F.W. GOCAL, Peter R. BEETHAM, Keith A. WALKER
  • Publication number: 20140189906
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.
    Type: Application
    Filed: July 4, 2013
    Publication date: July 3, 2014
    Inventors: Gregory F.W. Gocal, Peter R. Beetham, Aura de Schopke, Sarah Dumm, James Pearce, Christian Schopke, Keith A. Walker
  • Publication number: 20140134696
    Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. Is certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.
    Type: Application
    Filed: June 25, 2013
    Publication date: May 15, 2014
    Inventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham
  • Patent number: 8470568
    Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: June 25, 2013
    Assignee: Nucelis Inc.
    Inventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham
  • Publication number: 20120122223
    Abstract: Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.
    Type: Application
    Filed: September 28, 2011
    Publication date: May 17, 2012
    Inventors: Gregory F.W. Gocal, Peter R. Beetham, Aura de Schopke, Sarah Dumm, James Pearce, Christian Schopke, Keith A. Walker
  • Patent number: 8106259
    Abstract: Mixed duplex oligonucleotides (MDON) are used to effect site-specific genetic alterations in a target DNA sequence of a plant. The MDON are introduced by electroporation into microspores. Thereafter, plants having a desired genetic alteration are produced by germinating the microspores.
    Type: Grant
    Filed: May 11, 2009
    Date of Patent: January 31, 2012
    Assignee: Cibus US LLC
    Inventors: Peter R. Beetham, Keith A. Walker, Patricia L. Avissar