Patents by Inventor Keith A. Walker
Keith A. Walker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11952577Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.Type: GrantFiled: January 9, 2017Date of Patent: April 9, 2024Assignee: NUCELIS LLCInventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham
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Publication number: 20220298525Abstract: Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.Type: ApplicationFiled: September 7, 2021Publication date: September 22, 2022Applicants: CIBUS US LLC, CIBUS EUROPE B.V.Inventors: Gregory F.W. Gocal, Peter R. Beetham, Aura Estela Gonzalez Schopke, Sarah Dumm, James Pearce, Christian Schopke, Keith A. Walker
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Patent number: 11160224Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide.Type: GrantFiled: July 30, 2018Date of Patent: November 2, 2021Assignee: CIBUS US LLCInventors: Peter R. Beetham, Patricia L. Avissar, Keith A. Walker, Richard A. Metz
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Patent number: 11111500Abstract: Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.Type: GrantFiled: July 23, 2018Date of Patent: September 7, 2021Assignees: CIBUS US LLC, CIBUS Europe B.V.Inventors: Gregory F. W. Gocal, Peter R. Beetham, Aura Estela Gonzalez Schopke, Sarah Dumm, James Pearce, Christian Schopke, Keith A. Walker
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Patent number: 10815495Abstract: Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the allene oxide synthase 2 gene (i.e., AOS2). In some embodiments the disclosure relates to plants that are pathogen resistant.Type: GrantFiled: October 16, 2017Date of Patent: October 27, 2020Assignees: CIBUS US LLC, CIBUS EUROPE B.V.Inventors: Uvini Gunawardena, Gregory F. W. Gocal, Peter R. Beetham, Keith A. Walker
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Publication number: 20200123563Abstract: Provided are mutated acetohydroxyacid synthase (AHAS) nucleic acids and the proteins encoded by the mutated nucleic acids. Also provided are canola plants, cells, and seeds comprising the mutated genes.Type: ApplicationFiled: December 27, 2019Publication date: April 23, 2020Applicant: Cibus US LLCInventors: Christian Schopke, Gregory F. W. Gocal, Keith A. Walker, Peter R. Beetham
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Publication number: 20180355327Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide.Type: ApplicationFiled: July 30, 2018Publication date: December 13, 2018Applicant: CIBUS US LLCInventors: PETER R. BEETHAM, Patricia L. Avissar, Keith A. Walker, Richard A. Metz
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Publication number: 20180327773Abstract: Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.Type: ApplicationFiled: July 23, 2018Publication date: November 15, 2018Applicants: CIBUS US LLC, CIBUS EUROPE B.V.Inventors: Gregory F.W. Gocal, Peter R. Beetham, Aura Estela Gonzalez Schopke, Sarah Dumm, James Pearce, Christian Schopke, Keith A. Walker
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Patent number: 10100334Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically altered yeast and uses therefore. In some aspects and embodiments, the genetically altered yeast produce isoprenoids, preferably squalene. The genetically altered yeast may have alterations in the expression or activity of enzymes involved in squalene production, for example, acetyl-CoA carboxylase (or “ACCase”), HMG-CoA reductase, squalene epoxidase, and squalene synthase. One or more genes of a genetically altered yeast may be modified by gene repair oligonucleobases. Also are provided methods of producing squalene using a genetically altered yeast. The invention also provides squalene produced by genetically altered yeast.Type: GrantFiled: May 22, 2009Date of Patent: October 16, 2018Assignee: NUCELIS INC.Inventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham
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Patent number: 10035991Abstract: The present invention relates to the production of a non-transgenic plant resistant or tolerant to a herbicide of the phosphonomethylglycine family, e.g., glyphosate. The present invention also relates to the use of a recombinagenic oligonucleobase to make a desired mutation in the chromosomal or episomal sequences of a plant in the gene encoding for 5-enol pyruvylshikimate-3-phosphate synthase (EPSPS). The mutated protein, which substantially maintains the catalytic activity of the wild-type protein, allows for increased resistance or tolerance of the plant to a herbicide of the phosphonomethylglycine family, and allows for the substantially normal growth or development of the plant, its organs, tissues or cells as compared to the wild-type plant irrespective of the presence or absence of the herbicide.Type: GrantFiled: November 16, 2007Date of Patent: July 31, 2018Assignee: CIBUS US LLCInventors: Peter R. Beetham, Patricia L. Avissar, Keith A. Walker, Richard A. Metz
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Publication number: 20180051296Abstract: Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the allene oxide synthase 2 gene (i.e., AOS2). In some embodiments the disclosure relates to plants that are pathogen resistant.Type: ApplicationFiled: October 16, 2017Publication date: February 22, 2018Applicants: CIBUS US LLC, CIBUS EUROPE B.V.Inventors: Uvini GUNAWARDENA, Gregory F.W. GOCAL, Peter R. BEETHAM, Keith A. WALKER
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Patent number: 9790515Abstract: Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the allene oxide synthase 2 gene (i.e., AOS2). In some embodiments the disclosure relates to plants that are pathogen resistant.Type: GrantFiled: March 14, 2014Date of Patent: October 17, 2017Assignees: CIBUS US LLC, CIBUS EUROPE B.V.Inventors: Uvini Gunawardena, Gregory F. W. Gocal, Peter R. Beetham, Keith A. Walker
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Publication number: 20170145429Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.Type: ApplicationFiled: January 9, 2017Publication date: May 25, 2017Inventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham
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Patent number: 9540662Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.Type: GrantFiled: June 25, 2013Date of Patent: January 10, 2017Assignee: NUCELIS LLCInventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham
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Publication number: 20160145638Abstract: Provided are compositions and methods relating to gene and/or protein mutations in plants. In certain embodiments, the disclosure relates to mutations in the allene oxide synthase 2 gene (i.e., AOS2). In some embodiments the disclosure relates to plants that are pathogen resistant.Type: ApplicationFiled: March 14, 2014Publication date: May 26, 2016Applicants: CIBUS US LLC, CIBUS EUROPE B.V.Inventors: Uvini GUNAWARDENA, Gregory F.W. GOCAL, Peter R. BEETHAM, Keith A. WALKER
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Publication number: 20140189906Abstract: Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.Type: ApplicationFiled: July 4, 2013Publication date: July 3, 2014Inventors: Gregory F.W. Gocal, Peter R. Beetham, Aura de Schopke, Sarah Dumm, James Pearce, Christian Schopke, Keith A. Walker
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Publication number: 20140134696Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. Is certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.Type: ApplicationFiled: June 25, 2013Publication date: May 15, 2014Inventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham
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Patent number: 8470568Abstract: Provided herein compositions and methods for producing isoprenoids, including squalene. In certain aspects and embodiments provided are genetically converted yeast and uses therefore. In some aspects and embodiments, the genetically converted yeast produce isoprenoids, preferably squalene. Also are provided methods of producing squalene using a genetically converted yeast or a non-genetically converted yeast. The invention also provides squalene produced by genetically converted yeast or non-genetically converted yeast.Type: GrantFiled: November 22, 2010Date of Patent: June 25, 2013Assignee: Nucelis Inc.Inventors: Keith A. Walker, Mark E. Knuth, Noel M. Fong, Peter R. Beetham
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Publication number: 20120122223Abstract: Provided are compositions and methods relating to gene and/or protein mutations in transgenic or non-transgenic plants. In certain embodiments, the disclosure relates to mutations in the protoporphyrinogen IX (PPX) gene. In some embodiments the disclosure relates to plants that are herbicide resistant.Type: ApplicationFiled: September 28, 2011Publication date: May 17, 2012Inventors: Gregory F.W. Gocal, Peter R. Beetham, Aura de Schopke, Sarah Dumm, James Pearce, Christian Schopke, Keith A. Walker
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Patent number: 8106259Abstract: Mixed duplex oligonucleotides (MDON) are used to effect site-specific genetic alterations in a target DNA sequence of a plant. The MDON are introduced by electroporation into microspores. Thereafter, plants having a desired genetic alteration are produced by germinating the microspores.Type: GrantFiled: May 11, 2009Date of Patent: January 31, 2012Assignee: Cibus US LLCInventors: Peter R. Beetham, Keith A. Walker, Patricia L. Avissar