Abstract: The high-voltage and/or high-frequency pulse dielectric breakdown strength (DBS) of an implantable medical device is increased by strategically positioning insulation materials on or adjacent to the external surfaces of a filter capacitor. Dielectric breakdown strength is further increased by adding polymeric or ceramic nanoscale metal oxide insulative powders to the insulation materials.

Abstract: A self-centering washer is positioned between the feedthrough and filter capacitor of a filtered feedthrough. The washer has openings through which first and second terminal pins extend. A first opening has an inner arcuate portion contacting the first terminal pin and an outer perimeter portion exposing the braze sealing the terminal pin to the insulator. A second opening has an inner arcuate portion contacting the second terminal pin and an outer perimeter portion exposing the braze sealing the terminal pin to the insulator. In an imaginary configuration with the first and second washer openings superimposed one on top of the other, the cumulative arcuate distance of the inner arcuate portions about one of the terminal pins, subtracting overlap, results in a gap between the superimposed washer openings that is less than a diameter of the first and second terminal pins so that the washer is prevented from lateral movement.

Abstract: Provided herein are compositions and methods for photoaffinity labeling of molecular targets. In particular, probes that specifically interact with cellular targets based on their affinity and are then covalently linked to the cellular target via a photoreactive group (PRG) on the probe.

Abstract: Provided herein are systems and methods for characterizing target/ligand engagement. In particular, luciferase-labeled polypeptide targets are used to detect or quantify target/ligand engagement (e.g., within a cell or cell lysate).

Abstract: Provided herein are compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith.

Abstract: Provided herein are systems and methods for characterizing target/ligand engagement. In particular, luciferase-labeled polypeptide targets are used to detect or quantify target/ligand engagement (e.g., within a cell or cell lysate).

Abstract: Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.

Abstract: Provided herein are compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith.

Abstract: The present invention provides a method for selecting a card, lot, or number using a shuffling process that relies on measurements of movement, biometrics, or environmental data within interactive electronic media. The invention provides an alternative to random number generators for media which relies on random selection outputs such as divination tools or a game of chance. The incorporation of a user's movement or environmental data into the selection process provides an element of interest and amusement. The present invention also provides for a selection method that reliably generates a unique selection upon each use by utilizing precise measurements and mathematical formulas to catalogue and shuffle the cards or lots in a system.

Abstract: A single tracking URL collects tracking information for multiple tracking services based on multiple tracking URL templates. A dynamic link generator generates a tracking URL configured to collect tracking information requested by each of a set of enabled tracking URL templates. The tracking information is transmitted to the tracking services associated with the enabled tracking URL templates. Additionally or alternatively, a tracking URL is configured to redirect a consumer to one of a candidate set of destination URLs. A tracking URL includes a base URL, which is resolved to an IP address of a server of a particular tracking service. Based on tracking data associated with the tracking URL and/or digital body language associated with the consumer, the particular tracking service selects one of a candidate set of destination URLs associated with the tracking URL. A destination page corresponding to the selected destination URL is presented to the consumer.

Abstract: Disclosed herein are compounds, compositions, and methods for treating infections by bacteria and for killing bacteria. In particular, the disclosed compounds, compositions, and methods are useful for treating infections by bacteria and for killing persister bacteria that survive antibiotic treatment and then reconstitute infections.

Abstract: Disclosed herein are compounds, compositions, and methods for treating infections by bacteria and for killing bacteria. In particular, the disclosed compounds, compositions, and methods are useful for treating infections by bacteria and for killing persister bacteria that survive antibiotic treatment and then reconstitute infections.

Abstract: An electronic gaming machine includes a game display having a graphical user interface (GUI). A game controller is in communication with the game display. The game controller controls the GUI to present a selectable tournament button that causes the player to enter a game tournament, displays a plurality of selectable tournament game options for the game tournament, receives a tournament game selection response indicating a selected one of the options, displays the selected tournament game, displays at the GUI during the selected tournament game, an exit button that returns the display to the base game and maintains player progress in the selected tournament game, re-displays the tournament button upon returning to the base game, the re-displayed tournament button enables the player to return to the selected tournament game with the maintained player progress, and displays a prompt to card-in, and provide an enhanced return to player (RTP).

Abstract: Provided herein are compositions and methods for stabilizing coelenterazine and analogs or derivatives thereof, and for improving the solubility and reconstitution efficiency of coelenterazine and analogs and derivatives thereof.

Abstract: Provided herein are systems and methods for characterizing target/ligand engagement. In particular, luciferase-labeled polypeptide targets are used to detect or quantify target/ligand engagement (e.g., within a cell or cell lysate).

Abstract: Provided herein are compositions and methods for stabilizing coelenterazine and analogs or derivatives thereof, and for improving the solubility and reconstitution efficiency of coelenterazine and analogs and derivatives thereof.

Abstract: Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.

Abstract: An electronic gaming machine includes a game display having a graphical user interface (GUI). A game controller is in communication with the game display. The game controller controls the GUI to present a selectable tournament button that causes the player to enter a game tournament, displays a plurality of selectable tournament game options for the game tournament, receives a tournament game selection response indicating a selected one of the options, displays the selected tournament game, displays at the GUI during the selected tournament game, an exit button that returns the display to the base game and maintains player progress in the selected tournament game, re-displays the tournament button upon returning to the base game, the re-displayed tournament button enables the player to return to the selected tournament game with the maintained player progress, and displays a prompt to card-in, and provide an enhanced return to player (RTP).

Abstract: Systems, methods, and apparatuses may include a network onboarding manager for configuring network security features at application hosting sites of a service provider network, for instance, as part of a procedure for deploying an application onto the service provider network. The network onboarding manager may generate a security profile for the application. The security profile may include information indicating a security posture of the application with respect to network security features needed to deploy the application, which the system may use to generate and send configuration data to the hosting sites. One or more operations may be performed based on a user input received at a developer portal (e.g., via a user interface), or automatically based on one or more API calls made by the network onboarding manager and/or based on one or more security profile templates.

Abstract: A shared session cache can be accessible by multiple load balancers, and can indicate whether client devices are associated with specific backend servers of a server pool. When a client device connects to a load balancer, the load balancer can use the shared session cache to determine if the client device is already associated with a specific backend server. If so, the load balancer can connect the client device to that specific backend server so that it can continue an existing session with the specific backend server. If not, the load balancer can select a new backend server for the client device, connect the client device to the newly selected backend server, and create an entry in the shared session cache indicating that the client device is associated with the newly selected backend server.