Patents by Inventor Keith Abe

Keith Abe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Unit dose formulations and methods of treating thrombosis with an oral factor Xa inhibitor
    Patent number: 8404724
    Abstract: Unit doses of factor Xa inhibitor compounds and methods of using these compounds for inhibiting blood coagulation in a human patient are taught herein. The unit dose of the factor Xa inhibitor compounds disclosed herein required to inhibit coagulation in a primate is lower than the unit dose required to obtain similar levels of coagulation inhibition in other animal models, such as rodents. Also taught are in vitro assays useful in predicting in vivo antithrombotic activity in humans.
    Type: Grant
    Filed: December 7, 2007
    Date of Patent: March 26, 2013
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Uma Sinha, Stanley J. Hollenbach, Keith Abe
  • Unit dose formulations and methods of treating thrombosis with an oral factor Xa inhibitor
    Publication number: 20080153876
    Abstract: Unit doses of factor Xa inhibitor compounds and methods of using these compounds for inhibiting blood coagulation in a human patient are taught herein. The unit dose of the factor Xa inhibitor compounds disclosed herein required to inhibit coagulation in a primate is lower than the unit dose required to obtain similar levels of coagulation inhibition in other animal models, such as rodents. Also taught are in vitro assays useful in predicting in vivo antithrombotic activity in humans.
    Type: Application
    Filed: December 7, 2007
    Publication date: June 26, 2008
    Inventors: Uma Sinha, Stanley J. Hollenbach, Keith Abe