Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in the LXRB gene. Such transgenic mice are useful as models for disease, such as diabetes. The present invention is also directed to identifying agents that modulate LXRB gene function, and as potential treatments for various disease states and disease conditions, including diabetes.

Abstract: The present invention relates to compositions and methods relating to the characterization and function of RPTPB. Specifically, the present invention provides transgenic animals comprising disruptions in a RPTPB gene and methods of treating diseases conditions, such as depression. The present invention further relates to agents that modulate RPTPB and methods of screening for agents that modulate RPTPB for the treatment of diseases and conditions such as depression.

Abstract: The present invention relates to compositions and methods relating to the characterization and function of CYT28. Specifically, the present invention provides transgenic animals comprising disruptions in a CYT28 gene and methods of treating diseases conditions, such as pain. The present invention further relates to agents that modulate CYT28 and methods of screening for agents that modulate CYT28 for the treatment of diseases and conditions such as pain.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a glucocorticoid-induced receptor gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present disclosure relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present disclosure provides transgenic mice comprising mutations in a delta-opioid receptor gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a NTTP1 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in an n-CL4 cysteine protease gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a CLCN4 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a Kir5.1 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a GPCR-like gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a chemokine receptor 9A gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to compositions and methods relating to the characterization of gene function. More particularly, the present invention relates to the role of secreted protein genes involved in neurobiological disorders, and in particular, depression. In addition, the present invention provides transgenic mice comprising mutations in a secreted protein gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions, including depression.

Abstract: The present invention is a data query and analysis tool useful for identifying patterns in experimental data. The methods and systems of the current invention provide context for biological data, including metabolic, gene expression and proteomic data, by applying the data to a network representation of biological processes. In doing so, Nodewalker moves beyond the traditional linear pathway view of biology to a network view, and uses the network as a data integration tool to seamlessly merge disparate data streams.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a CXCR6 gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising mutations in a BSMAP gene. Such transgenic mice are useful as models for disease and for identifying agents that modulate gene expression and gene function, and as potential treatments for various disease states and disease conditions.

Abstract: This invention provides methods of forming new blood vessels in diseased or damaged tissue in a subject, methods of increasing blood flow to diseased or damaged tissue in a subject, and methods of increasing angiogenesis in diseased tissue in a subject, which methods comprise: a) isolating autologous bone marrow-mononuclear cells from the subject; and b) transplanting locally into the diseased or damaged tissue an effective amount of the autologous bone-marrow mononuclear cells, thereby forming new blood vessels in the diseased or damaged tissue. The new blood vessels may be capillaries or collateral vessels in ischemic tissue or any site of angiogenesis. Also provided are methods of treating tissue in disease or injury by local transplantation with an effective amount of the autologous bone marrow-mononuclear cells so as to induce vascularization in such diseased tissue.

Abstract: A roller peg includes a housing, a roller, a pin, and a keeper. The pin affixes the roller inside the housing such that a surface of the roller protrudes from a hole in the side of the housing. The keeper holds the pin and roller in place within the housing. The roller spins within the housing when a surface of the roller contacts an exterior surface.

Abstract: Broadband access is provided to a virtual private network (VPN), including multiple local area networks (LANs) configured to interface with an IPv6 service provider network. Data to be routed from an originating device in an originating LAN to a destination device in a destination LAN is received by an ingress line interface and encapsulated in an IPv6 packet. A unique identification number assigned to the VPN is added to the IPv6 packet. When the destination device's address is not mapped to a corresponding egress line interface, the IPv6 packet is broadcast to a multicast address associated with the VPN. When the destination device's address is mapped to the egress line interface, the IPv6 packet is unicast to the egress line interface. The data is ultimately received and decapsulated by the egress line interface. After the VPN identification number is verified, the data is transmitted to the destination device.

Abstract: Data packets of a subscriber are addressed for transmission from an originating device through an IP network to a destination network. A DHCP request, associated with a first subscriber IP address from the IP network, is received from the originating device and routed through the IP network to a destination device in the destination network using an IP network address of the destination device. The destination device forwards the DHCP request to a DHCP server. A DHCP response is received from the DHCP server, through the destination device, including a second subscriber IP address associated with the destination network. The DHCP response is sent through the IP network to the originating device using the first subscriber IP address. The originating device obtains the second subscriber IP address from the DHCP response and addresses data packets using the first and second subscriber IP addresses.