Patents by Inventor Keith B. Neeves
Keith B. Neeves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 10722250Abstract: The invention relates to a magnetic-field driven colloidal microbot that employs wall-based propulsion, method of forming the microbot and a method of using the microbot. The microbot can be formed in situ with the use of magnetic fields, and the magnetic fields can be used to translate the microbot to a specified location in a patient. The microbot does not depend on “swimming” or flow currents within a patient to move, but instead can propel itself along a surface using a magnetic field. Once the magnetic field is removed, the microbot disassembles into colloidal particles.Type: GrantFiled: March 14, 2016Date of Patent: July 28, 2020Assignee: Colorado School of MinesInventors: Tonguc Onur Tasci, Keith B. Neeves, David W. M. Marr
-
Publication number: 20170370953Abstract: A method for evaluating a blood product of an individual are provided. Specifically, a method to utilize a microfluidic flow assay, which includes a substrate surface comprising lipid coated particles and microfluidic channels through which a blood product can flow. The lipid coated particles comprise functional molecules that can induce or inhibit the coagulation cascade.Type: ApplicationFiled: July 11, 2017Publication date: December 28, 2017Applicant: Colorado School of MinesInventors: Keith B. Neeves, Abimbola Onasoga
-
Patent number: 9844585Abstract: An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e.g., a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device. The device may be rigid, or flexible, in which case a flexible device can be attached to a bio-degradable support scaffold that provides sufficient structural rigidity for insertion of the device into the target tissue.Type: GrantFiled: June 25, 2014Date of Patent: December 19, 2017Assignees: YALE UNIVERSITY, CORNELL UNIVERSITYInventors: William L. Olbricht, Keith B. Neeves, Conor Foley, Russell T. Matthews, W. Mark Saltzman, Andrew Sawyer
-
Patent number: 9709579Abstract: A microfluidic-based flow assay and methods of manufacturing the same are provided. Specifically, the microfluidic flow assay includes a substrate surface comprising lipid coated particles and microfluidic channels through which a blood product can flow. The lipid coated particles comprise functional molecules that can induce or inhibit the coagulation cascade.Type: GrantFiled: June 27, 2013Date of Patent: July 18, 2017Assignee: Colorado School of MinesInventors: Keith B. Neeves, Abimbola Onasoga
-
Patent number: 9487812Abstract: A microfluidic system, device, and method are disclosed. The microfluidic system may include a first microfluidic channel and a second microfluidic channel, each of which are carrying one or more objects. There is an intersection between the first and second microfluidic channels where one or more objects from the first microfluidic channel impact one or more objects from the second microfluidic channel under hydrodynamic forces. The impact causes the objects to deform and the deformation of objects can be analyzed to determine properties of the object.Type: GrantFiled: February 19, 2013Date of Patent: November 8, 2016Assignee: Colorado School of MinesInventors: Keith B. Neeves, David W. M. Marr, Kevin B. Roth, Charles D. Eggleton
-
Publication number: 20160263391Abstract: The invention relates to a magnetic-field driven colloidal microbot that employs wall-based propulsion, method of forming the microbot and a method of using the microbot. The microbot can be formed in situ with the use of magnetic fields, and the magnetic fields can be used to translate the microbot to a specified location in a patient. The microbot does not depend on “swimming” or flow currents within a patient to move, but instead can propel itself along a surface using a magnetic field. Once the magnetic field is removed, the microbot disassembles into colloidal particles.Type: ApplicationFiled: March 14, 2016Publication date: September 15, 2016Inventors: Tonguc Onur Tasci, Keith B. Neeves, David W.M. Marr
-
Publication number: 20140371712Abstract: An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e.g., a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device. The device may be rigid, or flexible, in which case a flexible device can be attached to a bio-degradable support scaffold that provides sufficient structural rigidity for insertion of the device into the target tissue.Type: ApplicationFiled: June 25, 2014Publication date: December 18, 2014Applicants: YALE UNIVERSITY, CORNELL UNIVERSITYInventors: William L. Olbricht, Keith B. Neeves, Conor Foley, Russell T. Matthews, W. Mark Saltzman, Andrew Sawyer
-
Patent number: 8790317Abstract: An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (eg, a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device.Type: GrantFiled: February 12, 2008Date of Patent: July 29, 2014Assignees: Cornell University, Yale UniversityInventors: William L. Olbricht, Keith B. Neeves, Conor Foley, Russell T. Mattews, W. Mark Saltzman, Andrew Sawyer
-
Publication number: 20140038214Abstract: A microfluidic-based flow assay and methods of manufacturing the same are provided. Specifically, the microfluidic flow assay includes a substrate surface comprising lipid coated particles and microfluidic channels through which a blood product can flow. The lipid coated particles comprise functional molecules that can induce or inhibit the coagulation cascade.Type: ApplicationFiled: June 27, 2013Publication date: February 6, 2014Inventors: Keith B. Neeves, Abimbola Onasoga
-
Publication number: 20130230879Abstract: A microfluidic system, device, and method are disclosed. The microfluidic system may include a first microfluidic channel and a second microfluidic channel, each of which are carrying one or more objects. There is an intersection between the first and second microfluidic channels where one or more objects from the first microfluidic channel impact one or more objects from the second microfluidic channel under hydrodynamic forces. The impact causes the objects to deform and the deformation of objects can be analyzed to determine properties of the object.Type: ApplicationFiled: February 19, 2013Publication date: September 5, 2013Applicant: COLORADO SCHOOL OF MINESInventors: Keith B. Neeves, David W.M. Marr, Kevin B. Roth, Charles D. Eggleton
-
Publication number: 20100098767Abstract: An embodiment of the invention is directed to a microfabr?cated, silicon-based, Convection Enhanced Delivery (CED) device The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e g, a drug) to the microfabricated device The device may have multiple channels disposed side by side or in different surfaces of the deviceType: ApplicationFiled: February 12, 2008Publication date: April 22, 2010Inventors: William L. Olbricht, Keith B. Neeves, Conor Foley, Russell T. Mattews, Mark W. Saltzman, Andrew Sawyer