Patents by Inventor Keith B. Neeves

Keith B. Neeves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10722250
    Abstract: The invention relates to a magnetic-field driven colloidal microbot that employs wall-based propulsion, method of forming the microbot and a method of using the microbot. The microbot can be formed in situ with the use of magnetic fields, and the magnetic fields can be used to translate the microbot to a specified location in a patient. The microbot does not depend on “swimming” or flow currents within a patient to move, but instead can propel itself along a surface using a magnetic field. Once the magnetic field is removed, the microbot disassembles into colloidal particles.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: July 28, 2020
    Assignee: Colorado School of Mines
    Inventors: Tonguc Onur Tasci, Keith B. Neeves, David W. M. Marr
  • Publication number: 20170370953
    Abstract: A method for evaluating a blood product of an individual are provided. Specifically, a method to utilize a microfluidic flow assay, which includes a substrate surface comprising lipid coated particles and microfluidic channels through which a blood product can flow. The lipid coated particles comprise functional molecules that can induce or inhibit the coagulation cascade.
    Type: Application
    Filed: July 11, 2017
    Publication date: December 28, 2017
    Applicant: Colorado School of Mines
    Inventors: Keith B. Neeves, Abimbola Onasoga
  • Patent number: 9844585
    Abstract: An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e.g., a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device. The device may be rigid, or flexible, in which case a flexible device can be attached to a bio-degradable support scaffold that provides sufficient structural rigidity for insertion of the device into the target tissue.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: December 19, 2017
    Assignees: YALE UNIVERSITY, CORNELL UNIVERSITY
    Inventors: William L. Olbricht, Keith B. Neeves, Conor Foley, Russell T. Matthews, W. Mark Saltzman, Andrew Sawyer
  • Patent number: 9709579
    Abstract: A microfluidic-based flow assay and methods of manufacturing the same are provided. Specifically, the microfluidic flow assay includes a substrate surface comprising lipid coated particles and microfluidic channels through which a blood product can flow. The lipid coated particles comprise functional molecules that can induce or inhibit the coagulation cascade.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: July 18, 2017
    Assignee: Colorado School of Mines
    Inventors: Keith B. Neeves, Abimbola Onasoga
  • Patent number: 9487812
    Abstract: A microfluidic system, device, and method are disclosed. The microfluidic system may include a first microfluidic channel and a second microfluidic channel, each of which are carrying one or more objects. There is an intersection between the first and second microfluidic channels where one or more objects from the first microfluidic channel impact one or more objects from the second microfluidic channel under hydrodynamic forces. The impact causes the objects to deform and the deformation of objects can be analyzed to determine properties of the object.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: November 8, 2016
    Assignee: Colorado School of Mines
    Inventors: Keith B. Neeves, David W. M. Marr, Kevin B. Roth, Charles D. Eggleton
  • Publication number: 20160263391
    Abstract: The invention relates to a magnetic-field driven colloidal microbot that employs wall-based propulsion, method of forming the microbot and a method of using the microbot. The microbot can be formed in situ with the use of magnetic fields, and the magnetic fields can be used to translate the microbot to a specified location in a patient. The microbot does not depend on “swimming” or flow currents within a patient to move, but instead can propel itself along a surface using a magnetic field. Once the magnetic field is removed, the microbot disassembles into colloidal particles.
    Type: Application
    Filed: March 14, 2016
    Publication date: September 15, 2016
    Inventors: Tonguc Onur Tasci, Keith B. Neeves, David W.M. Marr
  • Publication number: 20140371712
    Abstract: An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e.g., a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device. The device may be rigid, or flexible, in which case a flexible device can be attached to a bio-degradable support scaffold that provides sufficient structural rigidity for insertion of the device into the target tissue.
    Type: Application
    Filed: June 25, 2014
    Publication date: December 18, 2014
    Applicants: YALE UNIVERSITY, CORNELL UNIVERSITY
    Inventors: William L. Olbricht, Keith B. Neeves, Conor Foley, Russell T. Matthews, W. Mark Saltzman, Andrew Sawyer
  • Patent number: 8790317
    Abstract: An embodiment of the invention is directed to a microfabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (eg, a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device.
    Type: Grant
    Filed: February 12, 2008
    Date of Patent: July 29, 2014
    Assignees: Cornell University, Yale University
    Inventors: William L. Olbricht, Keith B. Neeves, Conor Foley, Russell T. Mattews, W. Mark Saltzman, Andrew Sawyer
  • Publication number: 20140038214
    Abstract: A microfluidic-based flow assay and methods of manufacturing the same are provided. Specifically, the microfluidic flow assay includes a substrate surface comprising lipid coated particles and microfluidic channels through which a blood product can flow. The lipid coated particles comprise functional molecules that can induce or inhibit the coagulation cascade.
    Type: Application
    Filed: June 27, 2013
    Publication date: February 6, 2014
    Inventors: Keith B. Neeves, Abimbola Onasoga
  • Publication number: 20130230879
    Abstract: A microfluidic system, device, and method are disclosed. The microfluidic system may include a first microfluidic channel and a second microfluidic channel, each of which are carrying one or more objects. There is an intersection between the first and second microfluidic channels where one or more objects from the first microfluidic channel impact one or more objects from the second microfluidic channel under hydrodynamic forces. The impact causes the objects to deform and the deformation of objects can be analyzed to determine properties of the object.
    Type: Application
    Filed: February 19, 2013
    Publication date: September 5, 2013
    Applicant: COLORADO SCHOOL OF MINES
    Inventors: Keith B. Neeves, David W.M. Marr, Kevin B. Roth, Charles D. Eggleton
  • Publication number: 20100098767
    Abstract: An embodiment of the invention is directed to a microfabr?cated, silicon-based, Convection Enhanced Delivery (CED) device The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e g, a drug) to the microfabricated device The device may have multiple channels disposed side by side or in different surfaces of the device
    Type: Application
    Filed: February 12, 2008
    Publication date: April 22, 2010
    Inventors: William L. Olbricht, Keith B. Neeves, Conor Foley, Russell T. Mattews, Mark W. Saltzman, Andrew Sawyer