Patents by Inventor Keith Brew

Keith Brew has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds
    Publication number: 20090318342
    Abstract: A mutant TIMP-3 (Tissue Inhibitor of MetalloProteinase-3) polypeptide wherein an additional residue or residues, for example an alanine residue, precedes the N-terminal residue of the TIMP-3 polypeptide; or wherein the residue corresponding to Threonine2 of TIMP-3 is mutated to Glycine. Such a mutant is considered to retain activity as an inhibitor of ADAMs, such as TACE, ADAMTS-4 and ADAMTS-5, but to have reduced activity as an inhibitor of MMPs.
    Type: Application
    Filed: July 28, 2006
    Publication date: December 24, 2009
    Applicant: IMPERIAL INNOVATIONS LIMITED
    Inventors: Hideaki Nagase, Keith Brew