Patents by Inventor Keith C. Meyer

Keith C. Meyer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for measuring activity of a specific fraction of albumin
    Patent number: 7968306
    Abstract: Methods of measuring the SFA and sPLA2 activities in a mammalian subject are provided. The methods include: providing a substrate comprising a fluorescently labeled carboxylic acid and a negatively charged phospholipid in an organic solvent such as ethanol, mixing the substrate with phospholipase A2 and a biological sample from the subject, and detecting the fluorescence intensity change to determine the SFA and sPLA2 activity in the sample. A decrease in SFA activity in the test sample as compared to the SFA activity in the control sample indicates that the subject has developed or is about to develop inflammation. An increase in sPLA2 activity in the test sample as compared to the sPLA2 activity in the control sample indicates that the subject has developed or is about to develop inflammation. Further disclosed is a kit for practicing the above methods.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: June 28, 2011
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Francis H. C. Tsao, Keith C. Meyer
  • Method For Measuring Activity of a Specific Fraction of Albumin
    Publication number: 20090230325
    Abstract: Methods of measuring the SFA and sPLA2 activities in a mammalian subject are provided. The methods include: providing a substrate comprising a fluorescently labeled carboxylic acid and a negatively charged phospholipid in an organic solvent such as ethanol, mixing the substrate with phospholipase A2 and a biological sample from the subject, and detecting the fluorescence intensity change to determine the SFA and sPLA2 activity in the sample. A decrease in SFA activity in the test sample as compared to the SFA activity in the control sample indicates that the subject has developed or is about to develop inflammation. An increase in sPLA2 activity in the test sample as compared to the sPLA2 activity in the control sample indicates that the subject has developed or is about to develop inflammation. Further disclosed is a kit for practicing the above methods.
    Type: Application
    Filed: December 12, 2008
    Publication date: September 17, 2009
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Francis H.C. Tsao, Keith C. Meyer
  • Fluorescent phospholipase assay, phospholipase A2 inhibitor and stimulator, and the use thereof
    Patent number: 7579156
    Abstract: A fluorescent phospholipase assay is disclosed. Further disclosed are the identification of alpha-1-antitrypsin as a phospholipase A2 stimulator and phospholipase C inhibitor and the identification of mercaptalbumin as a phospholipase A2 inhibitor. Various applications involving the use of the phospholipase assay, alpha-1-antitrypsin and mercaptalbumin are also disclosed.
    Type: Grant
    Filed: February 12, 2003
    Date of Patent: August 25, 2009
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Francis H. C. Tsao, Keith C. Meyer
  • Fluorescent phospholipase assay, phospholipase A2 inhibitor and stimulator, and the use thereof
    Publication number: 20030219849
    Abstract: A fluorescent phospholipase assay is disclosed. Further disclosed are the identification of alpha-1-antitrypsin as a phospholipase A2 stimulator and phospholipase C inhibitor and the identification of mercaptalbumin as a phospholipase A2 inhibitor. Various applications involving the use of the phospholipase assay, alpha-1-antitrypsin and mercaptalbumin are also disclosed.
    Type: Application
    Filed: February 12, 2003
    Publication date: November 27, 2003
    Inventors: Francis H.C. Tsao, Keith C. Meyer
  • Method and composition for treating sleep apnea
    Publication number: 20020099033
    Abstract: Application of synthetic or naturally occurring lung surfactant to the posterior pharyngeal region prior to a period of sleep significantly reduces episodes of sleep disturbance resulting in apnea or hypopnea. The present invention provides lung surfactant in a convenient applicator container for easy use and storage. Incidents of oxygen desaturation are reduced, thereby lowering the risks of apnea-associated pathologies.
    Type: Application
    Filed: December 10, 2001
    Publication date: July 25, 2002
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Keith C. Meyer, M. Safwan Badr
  • Method and composition for treating sleep apnea
    Patent number: 6329352
    Abstract: Application of synthetic or naturally occurring lung surfactant to the posterior pharyngeal region prior to a period of sleep significantly reduces episodes of sleep disturbance resulting in apnea or hypopnea. The present invention provides lung surfactant in a convenient applicator container for easy use and storage. Incidents of oxygen desaturation are reduced, thereby lowering the risks of apnea-associated pathologies.
    Type: Grant
    Filed: May 17, 1999
    Date of Patent: December 11, 2001
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Keith C. Meyer, M. Safwan Badr
  • Method and composition for treating sleep apnea
    Patent number: 5958902
    Abstract: Application of synthetic or naturally occurring lung surfactant to the posterior pharyngeal region prior to a period of sleep significantly reduces episodes of sleep disturbance resulting in apnea or hypopnea. The present invention provides lung surfactant in a convenient applicator container for easy use and storage. Incidents of oxygen desaturation are reduced, thereby lowering the risks of apnea-associated pathologies.
    Type: Grant
    Filed: April 16, 1997
    Date of Patent: September 28, 1999
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Keith C. Meyer, M. Safwan Badr