Patents by Inventor Keith C Murdock

Keith C Murdock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anthracycline derivatives as solubilized pro-drugs
    Patent number: 5212291
    Abstract: The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guanidine, isourea, isothiourea and biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phosphoric acid.
    Type: Grant
    Filed: March 9, 1992
    Date of Patent: May 18, 1993
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Ving J. Lee
  • Quinolinecarboxylic acid derivatives as solubilized pro-drugs
    Patent number: 5116827
    Abstract: The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guanidine, isourea, isothiourea and biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phosphoric acid.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: May 26, 1992
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Ving J. Lee
  • Solubilized imidazole pro-drugs
    Patent number: 5077283
    Abstract: The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, quanidine, isourea, isothiourea and biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phosphoric acid.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: December 31, 1991
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Ving J. Lee
  • Solubilized pro-drugs
    Patent number: 5077282
    Abstract: The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guanidine, isourea, isothiourea and biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phosphoric acid.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: December 31, 1991
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Ving J. Lee
  • Solubilized pro-drugs
    Patent number: 5070082
    Abstract: The N-phosphorylation of basic nitrogenous drug compounds to produce pro-drugs with enhanced water solubility or lipid solubility, or reduced toxicity, is disclosed. Drugs containing amine, amidine, guadinine, isourea, isothiourea an biguanide functions may be converted to such pro-drugs. The pro-drugs are hydrolyzed in the body, regenerating the original drugs with the release of a salt of phsophoric acid.
    Type: Grant
    Filed: March 18, 1991
    Date of Patent: December 3, 1991
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Ving J. Lee
  • Acylation products of bis(2-imidazolin-2-ylhydrazones) of 9,10-anthracenedicarboxaldehyde
    Patent number: 4900838
    Abstract: N-acylated derivatives of bis(2-imidazolin-2-ylhydrazones) of 9,10-anthracenedicarboxaldehyde, useful as anti-cancer agents against certain strains in mice, are disclosed and described, including processes for manufacture and use.
    Type: Grant
    Filed: September 22, 1988
    Date of Patent: February 13, 1990
    Assignee: American Cyanamid Company
    Inventor: Keith C. Murdock
  • Novel 1,4-bis(substituted-amino(-5,8-dihydroxyanthraquinones and leuco bases thereof
    Patent number: 4888137
    Abstract: This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.
    Type: Grant
    Filed: April 27, 1987
    Date of Patent: December 19, 1989
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • 1,4-bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
    Patent number: 4820738
    Abstract: This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.
    Type: Grant
    Filed: January 28, 1986
    Date of Patent: April 11, 1989
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • Antitumor amino acid and peptide derivatives of 1,4-bis(aminoalkyl and hydroxy-aminoalkyl)amino)-5,8-dihydroxyanthraquinones
    Patent number: 4732970
    Abstract: Antitumor amino acid and peptide derivatives of 1,4-bis[(aminoalkyl and hydroxyaminoalkyl)amino]-5,8-dihydroxyanthraquinones.
    Type: Grant
    Filed: June 13, 1986
    Date of Patent: March 22, 1988
    Assignee: American Cyanamid Company
    Inventors: Thomas L. Fields, Keith C. Murdock, Martin L. Sassiver, Janis Upeslacis
  • Process for preparing certain 1,4-di[.omega.-(2-hydroxyethylamino)alkylamino]anthraquinone free bases
    Patent number: 4715993
    Abstract: This disclosure describes a novel process for liberating the free bases of certain 1,4-di[.omega.-(2-hydroxyethylamino)alkylamino]anthraquinones from the salts thereof.
    Type: Grant
    Filed: June 14, 1985
    Date of Patent: December 29, 1987
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Richard L. Webb
  • Method of treating transplanted tumors and modulating the immune response
    Patent number: 4696935
    Abstract: This disclosure describes compositions of matter useful for inducing the regression of transplanted tumors in warm-blooded animals and for enhancing the immune system, and the method of treatment of transplanted tumors and enhancing the immune response in mammals therewith, the active ingredients of said compositions of matter being 3,6-bis[2-(1-piperidino)ethoxy]acridine or the pharmacologically acceptable acid-addition salts thereof.
    Type: Grant
    Filed: October 27, 1981
    Date of Patent: September 29, 1987
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Martin R. Damiani, Frederick E. Durr
  • 1,4-bis(substituted-amino)-5,8-dihydroxy anthraquinones and leuco bases thereof
    Patent number: 4614618
    Abstract: This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.
    Type: Grant
    Filed: July 22, 1985
    Date of Patent: September 30, 1986
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • Schiff bases of [(aminoalkyl or substituted aminoalkyl)amino]-9,10-anthracenediones
    Patent number: 4540788
    Abstract: This disclosure describes novel Schiff bases of 1,4-bis[(.omega.-aminoalkyl)amino]-9,10-anthracenediones and leuco bases thereof which are useful as chelating agents and for inducing regression of leukemia and/or inhibiting tumor growth in mammals.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: September 10, 1985
    Assignee: American Cyanamid Company
    Inventor: Keith C. Murdock
  • 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
    Patent number: 4540519
    Abstract: This disclosure describes symmetrical 1,4-bis-(substituted-amino)-5,8-hydroxyanthraquinones useful as chelating agents and for inducing regression and/or palliation of cancer diseases in mammals.
    Type: Grant
    Filed: April 9, 1984
    Date of Patent: September 10, 1985
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • Method of treating tumors in warm-blooded animals
    Patent number: 4540583
    Abstract: This disclosure describes novel compositions of matter useful as growth inhibitors of transplanted tumors in mammals and the method of inducing the regression and/or palliation of leukemia and solid tumors in mammals therewith, the active ingredients of said compositions of matter being certain symmetrical 1,4-bis(substituted-amino)anthraquinones and the non-toxic acid-addition salts thereof.
    Type: Grant
    Filed: December 8, 1980
    Date of Patent: September 10, 1985
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • 1,4-Bis (substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
    Patent number: 4526989
    Abstract: This disclosure describes symmetrical 1,4-bis (substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.
    Type: Grant
    Filed: October 23, 1979
    Date of Patent: July 2, 1985
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • Polymeric[[(oxazolidinyl)alkyl]amino]anthraquinones
    Patent number: 4526788
    Abstract: This disclosure describes novel polymeric 1,4-bis-[(1,3-oxazolidin-3-yl)alkylamino]anthraquinones prepared by condensation of 1,4-bis-[(2-hydroxyalkylamino)alkylamino]anthraquinones with dialdehydes which are useful as anti-cancer agents.
    Type: Grant
    Filed: March 18, 1983
    Date of Patent: July 2, 1985
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Richard L. Webb
  • Metal chelates of anthracene-9,10-bis-carbonylhydrazones
    Patent number: 4515954
    Abstract: This disclosure describes metal chelates of anthracene-9,10-bis-carbonylhydrazones and derivatives thereof useful as antibacterial agents, for inhibiting the growth of transplanted mouse tumors, and for inducing the regression and/or palliation of leukemia and related cancers.
    Type: Grant
    Filed: June 6, 1983
    Date of Patent: May 7, 1985
    Assignee: American Cyanamid Company
    Inventors: Stanley A. Lang, Jr., Keith C. Murdock
  • 1,4-Bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
    Patent number: 4456552
    Abstract: This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.
    Type: Grant
    Filed: March 2, 1981
    Date of Patent: June 26, 1984
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr
  • 1,4-Bis(substituted-amino)-5,8-dihydroxy-anthraquinones and leuco bases thereof
    Patent number: 4430501
    Abstract: This disclosure describes symmetrical 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.
    Type: Grant
    Filed: November 2, 1981
    Date of Patent: February 7, 1984
    Assignee: American Cyanamid Company
    Inventors: Keith C. Murdock, Frederick E. Durr