Patents by Inventor Keith Campbell
Keith Campbell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8631649Abstract: An engine exhaust component is provided. The engine exhaust component may include a plurality of coolant passages having parallel coolant flow, each coolant passage at least partially surrounding a respectively corresponding exhaust runner. The engine exhaust component may further include a coolant inlet manifold coupled to each of the coolant passages and a coolant outlet manifold coupled to each of the coolant passages. In this way, more even and controlled cooling can be provided.Type: GrantFiled: May 20, 2011Date of Patent: January 21, 2014Assignee: Ford Global Technologies, LLCInventors: Joel John Beltramo, Keith A. Campbell, Erich James Nowka, Ray Host, Robert Ralph Iorio
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Publication number: 20130102073Abstract: Activated human embryos produced by therapeutic cloning can give rise to human totipotent and pluripotent stem cells from which autologous cells for transplantation therapy are derived. The present invention provides methods for producing activated human embryos that can be used to generate totipotent and pluripotent stem cells from which autologous cells and tissues suitable for transplantation can be derived. The ability to create autologous human embryos represents a critical step towards generating immune-compatible stem cells that can be used to overcome the problem of immune rejection in regenerative medicine. The activated human embryos produced by the present invention also provide model systems for identifying and analyzing the molecular mechanisms of epigenetic imprinting and the genetic regulation of embryogenesis and development.Type: ApplicationFiled: October 16, 2012Publication date: April 25, 2013Applicant: ADVANCED CELL TECHNOLOGY, INC.Inventors: Jose Cibelli, Michael West, Keith Campbell
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Publication number: 20120291417Abstract: An engine exhaust component is provided. The engine exhaust component may include a plurality of coolant passages having parallel coolant flow, each coolant passage at least partially surrounding a respectively corresponding exhaust runner. The engine exhaust component may further include a coolant inlet manifold coupled to each of the coolant passages and a coolant outlet manifold coupled to each of the coolant passages. In this way, more even and controlled cooling can be provided.Type: ApplicationFiled: May 20, 2011Publication date: November 22, 2012Applicant: FORD GLOBAL TECHNOLOGIES, LLCInventors: Joel John Beltramo, Keith A. Campbell, Erich James Nowka, Ray Host, Robert Ralph Iorio
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Publication number: 20120177654Abstract: The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.Type: ApplicationFiled: December 23, 2011Publication date: July 12, 2012Applicant: THE UNIVERSITY OF MELBOURNEInventors: John Hamilton, Gary Peter Anderson, Ian Keith Campbell
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Patent number: 8142777Abstract: The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.Type: GrantFiled: September 18, 2007Date of Patent: March 27, 2012Assignee: The University of MelbourneInventors: John Hamilton, Ian Keith Campbell
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Patent number: 8062637Abstract: The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.Type: GrantFiled: July 9, 2009Date of Patent: November 22, 2011Assignee: MorphoSys AGInventors: John Hamilton, Ian Keith Campbell
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Publication number: 20110110934Abstract: The present invention relates generally to the use of antagonists of G-CSF, and/or its receptor (G-CSFR) in the treatment of uveitis. The present invention contemplates, therefore, the inhibition of G-CSF or G-CSFR systemically or locally and/or the down-regulation of expression of a G-CSF or G-CSFR in the treatment of uveitis.Type: ApplicationFiled: October 8, 2010Publication date: May 12, 2011Applicant: CSL LIMITEDInventors: Ian Peter Wicks, Ian Keith Campbell, Ann Leckie Cornish
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Publication number: 20090274702Abstract: The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.Type: ApplicationFiled: July 9, 2009Publication date: November 5, 2009Applicant: The University of MelbourneInventors: John Hamilton, Ian Keith Campbell
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Publication number: 20090137040Abstract: Activated human embryos produced by therapeutic cloning can give rise to human totipotent and pluripotent stem cells from which autologous cells for transplantation therapy are derived. The present invention provides methods for producing activated human embryos that can be used to generate totipotent and pluripotent stem cells from which autologous cells and tissues suitable for transplantation can be derived. In one embodiment, the invention provides methods for producing activated human embryos by parthenogenesis; in another embodiment, the invention provides methods for producing activated human embryos by somatic cell nuclear transfer whereby the genetic material of a differentiated human donor cell is reprogrammed to form a diploid human pronucleus capable of directing a cell to generate the stem cells from which autologous, isogenic cells for transplantation therapy are derived.Type: ApplicationFiled: September 17, 2008Publication date: May 28, 2009Applicant: ADVANCED CELL TECHNOLOGY, INC.Inventors: Jose Cibelli, Michael West, Keith Campbell
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Patent number: 7455836Abstract: The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.Type: GrantFiled: May 8, 2001Date of Patent: November 25, 2008Assignee: The University of MelbourneInventors: John Hamilton, Gary Peter Anderson, Ian Keith Campbell
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Publication number: 20080278042Abstract: A biosafety cabinet includes one or more air filters below the work surface and a system for holding, sealing, replacing and disposing the air filters through the work access opening of the biosafety cabinet. The air filters under the work surface of the biosafety cabinet capture particulates entering the cabinet from the exterior environment and the particulates within the cabinet's work chamber. Instead of a mechanical clamp, the perimeter of the air filters are sealed using a gasket and a tape, eliminating the accumulation of the contaminants around mechanical clamps. The air filters may be accessed through the work access opening of the biosafety cabinet, packaged for disposal and removed from the biosafety cabinet without being exposed to the exterior environment. A filter cover with an adhesive surface is used to cover and lift the used, contaminated air filter within the biosafety cabinet.Type: ApplicationFiled: January 23, 2008Publication date: November 13, 2008Applicant: The Baker CompanyInventors: Larry A. McCarthy, Robert E. Lloyd, D. Aaron Johnson, Robert A. Thibeault, Martin S. Rogers, Ronald W. Gingras, John Keith Campbell, Gene Klingbeil
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Publication number: 20080267930Abstract: A method of producing a reprogrammed cell or reprogrammed cell nucleus, comprising exposing a differentiated cell, or the nucleus of a differentiated cell to a cell or cell extract thereof derived from an oocyte, egg, ovary or early embryo of a cold blooded vertebrate, wherein the cold blooded vertebrate has one or more of the following properties: (i) a primitive vertebrate body plan including laterally projecting ribs and/or spinal projections; (ii) germ cells which do not contain germ plasm; and/or (iii) the oocyte, egg, ovary or early embryo cell or cell from which the cell extract is derived, expresses a highly conserved form of Oct-4 and/or nanog. There is also provided uses of the reprogrammed cells.Type: ApplicationFiled: July 21, 2006Publication date: October 30, 2008Applicant: The University of NottinghamInventors: Andrew Johnson, Keith Campbell, Ramiro Alberio
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Publication number: 20080131424Abstract: The present invention relates generally to a method for the treatment and prophylaxis of inflammatory conditions. The present invention is predicated in part on the identification of cells of the monocyte/macrophage lineage being critical for inflammation and, in particular, chronic inflammation. In accordance with the present invention, it is proposed that the reduction in levels of monocyte/macrophage-type cells and/or a reduction in the production of inflammatory and pro-inflammatory mediators by these cells, especially locally, is effective in reducing inflammatory conditions. The present invention further provides animal models useful for screening for reducing levels of monocyte/macrophage-type cells and/or reducing the production of inflammatory and pro-inflammatory mediators of these cells.Type: ApplicationFiled: September 18, 2007Publication date: June 5, 2008Inventors: John HAMILTON, Gary Peter Anderson, Ian Keith Campbell
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Publication number: 20070157037Abstract: An array of electronic devices includes at least one throttlable device in the array of devices and a management module connected to the at least one throttlable device for reducing heat effects to an overheating device from neighboring devices in the array of electronic devices device. The management module is configured to detect the overheating of the overheating device, detect at least one throttlable device neighboring the overheating device and in the array of devices, and throttle the at least one throttlable device. The array of devices are an array of blade servers within a blade center, and the management module is separate from the at least one throttlable device.Type: ApplicationFiled: December 30, 2005Publication date: July 5, 2007Applicant: International Business Machines CorporationInventors: Keith Campbell, Jeffery Franke, Donald Johnson, Brooks Johnston
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Publication number: 20070033664Abstract: A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state. Nuclear transfer may take place by cell fusion. The reconstituted embryo may then give rise to one or more animals. The invention is useful in the production of transgenic animals as well as non-transgenics of high genetic merit.Type: ApplicationFiled: October 6, 2006Publication date: February 8, 2007Inventors: Keith Campbell, Ian Wilmut
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Publication number: 20060249818Abstract: Low dielectric materials and films comprising same have been identified for improved performance when used as performance materials, for example, in interlevel dielectrics integrated circuits as well as methods for making same. In one aspect of the present invention, the performance of the dielectric material may be improved by controlling the weight percentage of ethylene oxide groups in the at least one porogen.Type: ApplicationFiled: July 11, 2006Publication date: November 9, 2006Inventors: Brian Peterson, John Kirner, Scott Weigel, James MacDougall, Lisa Deis, Thomas Braymer, Keith Campbell, Martin Devenney, C. Ramberg, Konstantinos Chondroudis, Keith Cendak
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Publication number: 20060249713Abstract: Low dielectric materials and films comprising same have been identified for improved performance when used as performance materials, for example, in interlevel dielectrics integrated circuits as well as methods for making same. In one aspect of the present invention, the performance of the dielectric material may be improved by controlling the weight percentage of ethylene oxide groups in the at least one porogen.Type: ApplicationFiled: July 11, 2006Publication date: November 9, 2006Inventors: Brian Peterson, John Kirner, Scott Weigel, James MacDougall, Thomas Deis, Lisa Deis, Thomas Braymer, Keith Campbell, Martin Devenney, C. Ramberg, Konstantinos Chondroudis, Keith Cendak
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Patent number: 7122671Abstract: A compound for use as a chemiluminescent label in immunoassay comprises an aryl acridinium ester linked to an N-succinimidyl moiety. The compound is conveniently linked to a monoclonal antibody or other protein and is used in a two-site immunoassay for the quantitation of an antigen of interest, by initiation of the luminescent reaction and subsequent measurement of the photonic emission of the immune complex formed during the immunological reaction.Type: GrantFiled: May 31, 1995Date of Patent: October 17, 2006Assignee: University College Cardiff Consultants LimitedInventors: Anthony Keith Campbell, James Stuart Woodhead, Ian Weeks
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Publication number: 20060156424Abstract: A method of reconstituting an animal embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in the G0 state. Nuclear transfer may take place by cell fusion. The reconstituted embryo may then give rise to one or more animals. The invention is useful in, the production of transgenic animals as well as non-transgenics of high genetic merit.Type: ApplicationFiled: November 3, 2005Publication date: July 13, 2006Inventors: Keith Campbell, Ian Wilmut
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Publication number: 20060064763Abstract: A method of reconstituting an animal embryo involves transferring a diploid nucleus into an oocyte which is arrested in the metaphase of the second meiotic division. The oocyte is not activated at the time of transfer, so that the donor nucleus is kept exposed to the recipient cytoplasm for a period of time. The diploid nucleus can be donated by a cell in either the G0 or G1 phase of the cell cycle at the time of transfer. Subsequently, the reconstituted embryo is activated. Correct ploidy is maintained during activation, for example, by incubating the reconstituted embryo in the presence of a microtubule inhibitor such as nocodazole. The reconstituted embryo may then give rise to one or more live animal births. The invention is useful in the production of transgenic animals as well as non-transgenics of high genetic merit.Type: ApplicationFiled: November 3, 2005Publication date: March 23, 2006Inventors: Keith Campbell, Ian Wilmut