Abstract: A stimulation system can have a first sensor to generate a first reading and a second sensor to generate a second reading. An analysis module of a programmer such as a patient programmer, which programs a stimulation signal to be delivered to a patient, conducts an evaluation of the patient based on the first and second readings. Evaluations may include determinations such as range of motion determinations, posture determinations, physical task-specific brain activity determinations, cognitive task-specific brain activity determinations, and brain activity-specific movement determinations.

Abstract: Disclosed is a method (100) of manufacturing a hot-runner system. The method (100) includes: a shipping operation (106), including shipping a partially constructed hot-runner component to a business entity, the business entity to build, at least in part, the hot-runner system using the partially constructed hot-runner component, the business entity to ship the hot-runner system to an end user, and the end user to use the hot-runner system in a molding system, the partially-completed hot-runner component being manufactured, at least in part, based on engineering data related to the partially-completed hot-runner component, and the engineering data being prepared, at least in part, the engineering data being related to the partially-completed hot-runner component, the partially-completed hot-runner component to be used in the hot-runner system.

Abstract: A method is provided for neuromodulation to treat stroke. One step of the method includes recording an input waveform from a first site in the nervous system in a source subject. The first site is healthy or at least partially functioning. Next, an output waveform is applied to a second site in the nervous system of a target subject suffering from the stoke. The second site is diseased due to the stroke.

Abstract: A single stand alone controller system (100) for controlling combination of hot-runner system (102) and mold assembly (104), assembly (104) connectable to system (102), controller system (100) comprising: processor (110); interface modules (112) configured to operatively couple to system (102) and assembly (104), processor (110) connected with modules (112); and controller-usable medium (114) embodying instructions (116) executable by processor (110), processor (110) connected with said medium (114), instructions (116) including: executable instructions for directing said processor (110) to control said system (102) and said assembly (104).

Abstract: Methods for neuromodulation using waveform signals. In certain embodiments, an input waveform is obtained from a signal source site in a source subject and an output waveform is applied to a target site in a target subject. The source subject is a human or animal and the signal source site is in the nervous system, including the brain. The source subject and target subject are the same subjects or different subjects. The output waveform is identical to the input waveform or derived from the input waveform. In some embodiments, the output waveform is modified in response to physiologic feedback. Also provided are systems for neuromodulation using waveform signals.

Abstract: A tool for assisting in the planning or performing of electrical neuromodulation of a patient's spinal cord. The tool may have various functions and capabilities, including calculating a volume of activation, registering an electrode(s) shown in a radiologic image, constructing functional images of the patient's spinal anatomy, targeting of neuromodulation, finding a functional midline between multiple electrodes, determining the three-dimensional position of multiple electrodes, and/or accommodating for electrode migration. In certain embodiments, the tool can be embodied as computer software or a computer system.

Abstract: A system and method for selection of stimulation parameters for Deep Brain Stimulation (DBS) may include a processor that displays in a display device and in relation to a displayed model of a leadwire including model electrodes, a current field corresponding to a first stimulation parameter set, provides a user interface for receipt of user input representing a shift of the current field, in response to the user input, moves, in the display device, the current field with respect to the displayed model, determines a second stimulation parameter set that results in the moved current field, and outputs the second stimulation parameter set and/or sets a stimulation device with the second stimulation parameter set, where the stimulation device is configured for performing a stimulation using the leadwire in accordance with the second stimulation parameter set.

Abstract: A system and method for selection of stimulation parameters for Deep Brain Stimulation (DBS) may include a processor that displays in a display device and in relation to a displayed model of a leadwire including model electrodes, a current field corresponding to a first stimulation parameter set, provides a user interface for receipt of user input representing a shift of the current field, in response to the user input, moves, in the display device, the current field with respect to the displayed model, determines a second stimulation parameter set that results in the moved current field, and outputs the second stimulation parameter set and/or sets a stimulation device with the second stimulation parameter set, where the stimulation device is configured for performing a stimulation using the leadwire in accordance with the second stimulation parameter set.

Abstract: A lead extension useful in deep brain stimulation treatment includes a body portion having a distal end and a proximal end, wherein the proximal end receives a stimulation signal from a generator. A lead interface is disposed at the distal end to send the stimulation signal to a brain stimulation lead. The lead extension also includes a sensor interface disposed at the distal end to receive an input signal from a sensor that is detached from the stimulation lead and send the input signal to the generator.

Abstract: An implantable medical electrical lead comprises a lead body extending between a distal end and a proximal end, and the distal end having at least one electrode of an electrode array extending longitudinally from the distal end toward the proximal end. The lead body at its proximal end may be coupled to a pulse generator, additional intermediate wiring, or other stimulation device. A fixation mechanism is formed on or integrally with the lead body proximal to the electrode array that is adapted to be implanted in and engage subcutaneous tissue, particularly muscle tissue, to inhibit axial movement of the lead body and dislodgement of the stimulation electrodes. The fixation mechanism comprises a plurality of tine elements arrayed in a tine element array along a segment of the lead.

Abstract: An implantable medical electrical lead particularly for stimulation of the sacral nerves comprises a lead body extending between a distal end and a proximal end, and the distal end having at least one electrode of an electrode array extending longitudinally from the distal end toward the proximal end. The lead body at its proximal end may be coupled to a pulse generator, additional intermediate wiring, or other stimulation device. A fixation mechanism is formed on or integrally with the lead body proximal to the electrode array that is adapted to be implanted in and engage subcutaneous tissue, particularly muscle tissue, to inhibit axial movement of the lead body and dislodgement of the stimulation electrodes.

Abstract: A lead extension useful in deep brain stimulation treatment includes a body portion having a distal end and a proximal end, wherein the proximal end receives a stimulation signal from a generator. A lead interface is disposed at the distal end to send the stimulation signal to a brain stimulation lead. The lead extension also includes a sensor interface disposed at the distal end to receive an input signal from a sensor that is detached from the stimulation lead and send the input signal to the generator.

Abstract: A burr hole assembly for use in neurosurgery. In one aspect, the burr hole assembly comprises a burr hole portion and one or more sensors, such as EEG sensors, temperature sensors, intracranial pressure sensors, or motion sensors. In certain embodiments, an input/output unit, which may include a multiplexer, provides a coupling between the sensors and a brain stimulation system which operates in cooperation with the burr hole assembly. In another aspect, the burr hole assembly comprises a burr hole portion and a rotation mechanism which operates in cooperation with an electrode lead. In certain embodiments, the burr hole assembly includes a control system for controlling the rotation mechanism. Also disclosed are systems comprising a burr hole assembly and various components of a brain stimulation system, such as pulse generators, electrode leads, lead extension, or external control systems.

Abstract: A single stand alone controller system (100) for controlling combination of hot-runner system (102) and mold assembly (104), assembly (104) connectable to system (102), controller system (100) comprising: processor (110); interface modules (112) configured to operatively couple to system (102) and assembly (104), processor (110) connected with modules (112); and controller-usable medium (114) embodying instructions (116) executable by processor (110), processor (110) connected with said medium (114), instructions (116) including: executable instructions for directing said processor (110) to control said system (102) and said assembly (104).

Abstract: Methods of neuromodulation in a live mammalian subject, such as a human patient. The method comprises applying an electrical signal to a target site in the nervous system, such as the brain, where the electrical signal comprises a series of pulses. The pulses includes a waveform shape that is more energy-efficient as compared to a corresponding rectangular waveform. Non-limiting examples of such energy-efficient waveforms include linear increasing, linear decreasing, exponential increasing, exponential decreasing, and Gaussian waveforms. Also described are apparatuses for neuromodulation and software for operating such apparatuses.

Abstract: A system and method for providing a volume of activation (VOA) of a stimulation electrode leadwire may include a processor that calculates a VOA for each of a plurality of sets of parameter settings of the leadwire, stores in a database each of the calculated VOAs in association with the respective set of parameter settings for which it was calculated, performs a curve fitting on threshold values determined for a plurality of waveforms to obtain an equation, obtains a set of parameter settings of the leadwire for a stimulation, and determines a VOA for the obtained set of parameter settings based on the stored VOAs, for example, using the equation.

Abstract: A system and method for selection of stimulation parameters for Deep Brain Stimulation (DBS) may include a processor that displays in a display device and in relation to a displayed model of a leadwire including model electrodes, a current field corresponding to a first stimulation parameter set, provides a user interface for receipt of user input representing a shift of the current field, in response to the user input, moves, in the display device, the current field with respect to the displayed model, determines a second stimulation parameter set that results in the moved current field, and outputs the second stimulation parameter set and/or sets a stimulation device with the second stimulation parameter set, where the stimulation device is configured for performing a stimulation using the leadwire in accordance with the second stimulation parameter set.

Abstract: A system and method for displaying a volume of activation (VOA) may include a processor that displays via a display device a model of a portion of a patient anatomy that includes anatomical structures, displays via the display device and overlying the display of the model a VOA associated by the processor with a set of anatomical stimulation parameter settings, the display of the VOA, and graphically identifies interactions between the displayed VOA and a first subset of the anatomical structures associated with one or more stimulation benefits and a second subset of the anatomical structures associated with one or more stimulation side effects, where the graphical identifications differ depending on whether the interaction is with the first subset or the second subset.

Abstract: A system and method for providing a volume of activation (VOA) of a stimulation electrode leadwire may include a processor that calculates a VOA for each of a plurality of sets of parameter settings of the leadwire, stores in a database each of the calculated VOAs in association with the respective set of parameter settings for which it was calculated, obtains a set of parameter settings of the leadwire for a stimulation, and determines a VOA for the obtained set of parameter settings based on the stored VOAs.

Abstract: A therapy tracking system and method may include a processor that obtains physiological information regarding a patient and a time period during which a deep brain stimulation (DBS) therapy is conducted. The information may be organized into a plurality of sessions. The processor may arrange in a display device a separate representation of the information for each of at least a subset of the sessions, such that the sessions are presented in order of time.