Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: An integrated circuit structure includes a device layer including a first set of devices and a second set of devices. An interconnect layer is above the device layer, where the interconnect layer includes one or more conductive interconnect features within dielectric material. In an example, a first ring structure including conductive material extends within the interconnect layer, and a second ring structure including conductive material extends within the interconnect layer. In an example, the second ring structure is non-overlapping with the first ring structure. In an example, the first ring structure is above the first set of devices of the device layer, and the second ring structure is above the second set of devices of the device layer.

Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: A beverage forming system and method in which a cartridge holder is movably mounted to the frame and has an opening to receive a cartridge. The cartridge holder may be arranged to hold and move a cartridge between an open position in which the opening of the cartridge holder is oriented in an upwardly inclined position to receive the cartridge, and a closed position in which the opening is oriented in a horizontal or downwardly inclined position. A cover may be arranged to cover the opening of the cartridge holder in a closed position, and the cover may be positioned away from the opening of the cartridge holder in an open position. A cartridge retainer may have an engagement portion arranged to hold the cartridge in the cartridge holder opening in at least a part of movement of the cartridge holder between the open and the closed positions.

Abstract: A beverage forming system and method in which a cartridge holder is movably mounted to the frame and has an opening to receive a cartridge. The cartridge holder may be arranged to hold and move a cartridge between an open position in which the opening of the cartridge holder is oriented in an upwardly inclined position to receive the cartridge, and a closed position in which the opening is oriented in a horizontal or downwardly inclined position. A cover may be arranged to cover the opening of the cartridge holder in a closed position, and the cover may be positioned away from the opening of the cartridge holder in an open position. A cartridge retainer may have an engagement portion arranged to hold the cartridge in the cartridge holder opening in at least a part of movement of the cartridge holder between the open and the closed positions.