Patents by Inventor Keith Dip Kei Luk
Keith Dip Kei Luk has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11786636Abstract: A simple, highly flexible and scalable platform for making functional complex tissues with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naïve subunits, exposing the undifferentiated or naïve subunits to different cell culture environments for induction of differentiation towards different lineages as required by that complex tissue, and combining the then functional subunits with or without the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and/or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. The bioengineered tissue graft can then used to replace dysfunctional tissue.Type: GrantFiled: June 14, 2011Date of Patent: October 17, 2023Assignee: VERSITECH LIMITEDInventors: Barbara Pui Chan, Hiu Wa Cheng, Daniel Tsz Kit Chik, Kenneth Man Chee Cheung, Keith Dip Kei Luk
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Patent number: 8444682Abstract: A mechanism to connect the supporting portions of orthopaedic implants such as in the head, spine, upper limb and lower limb and thereby prevent loosening and fretting at the implant interface of an orthopaedic implant construct has been developed based on shape memory effect and super-elasticity of shape memory materials such as nickel-titanium (nitinol or NiTi) shape-memory-alloy, without the use of typical threaded fastening technique. Advantages are conferred by making the entire device, not just connecting pieces, out of shape memory alloy and having shape memory effect and super-elasticity. Heating the memory head of the device will compress the connection portion without the use of an auxiliary device (e.g. coupling member) so that the connection portion can be completely clamped down by the memory head.Type: GrantFiled: September 11, 2007Date of Patent: May 21, 2013Assignee: The University of Hong KongInventors: Kelvin Wai Kwok Yeung, William Weijia Lu, Keith Dip Kei Luk, Kenneth Man Chee Cheung
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Publication number: 20120195848Abstract: The present invention provides bioactive bone cements that not only have sufficient radiopacity, low physiological toxicity, and requisite mechanism strength, but also promote local bone in-growth. The bone cement utilizes strontium salts as radiopacifiers, and comprises a powder component and a liquid component. In an embodiment, the powder component comprises a strontium salt, poly(methyl methacrylate) (PMMA), and a polymerization initiator; and the liquid component comprises methyl methacrylate (MMA) as reactive monomers and a polymerization accelerator.Type: ApplicationFiled: December 15, 2011Publication date: August 2, 2012Applicant: The University of Hong KongInventors: William Weijia Lu, Raymond Wing Moon Lam, Keith Dip-Kei Luk, Zhao Yang Li
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Publication number: 20120148632Abstract: A simple, highly flexible and scalable platform for making functional complex tissues with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naïve subunits, exposing the undifferentiated or naïve subunits to different cell culture environments for induction of differentiation towards different lineages as required by that complex tissue, and combining the then functional subunits with or without the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and/or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. The bioengineered tissue graft can then used to replace dysfunctional tissue.Type: ApplicationFiled: June 14, 2011Publication date: June 14, 2012Applicant: The University of Hong KongInventors: Barbara Pui Chan, Hiu Wa Cheng, Daniel Tsz Kit Chik, Kenneth Man Chee Cheung, Keith Dip Kei Luk
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Patent number: 8048618Abstract: A natural spinal disk including adjacent vertebral structures is removed from a deceased donor, rinsed in normal saline, preserved in a cryopreservative solution, and then frozen by gradually decreasing the temperature using liquid nitrogen or similar method. The implant may be thawed in normal saline solution and then implanted in a patient in need of a vertebral disk replacement.Type: GrantFiled: June 27, 2007Date of Patent: November 1, 2011Assignee: The University of Hong KongInventors: Keith Dip Kei Luk, Dike Ruan
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Publication number: 20110166251Abstract: Novel hybrid materials and fabrication methods thereof are provided. The novel hybrid materials can include a biodegradable polymer and a biodegradable metallic material. The hybrid material can also include a coupling agent between the biodegradable metallic material and the biodegradable polymer. A method of fabricating a hybrid material can include performing a surface treatment process on the biodegradable metallic material, and then either performing a solvent formation method or a thermal formation method.Type: ApplicationFiled: July 14, 2010Publication date: July 7, 2011Inventors: Karen Hoi Man Wong, Kelvin Wai Kwok Yeung, Kenneth Man Chee Cheung, Keith Dip Kei Luk, John Kin On Lam, Paul Kim Ho Chu
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Publication number: 20110046747Abstract: This invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules.Type: ApplicationFiled: February 16, 2010Publication date: February 24, 2011Inventors: Kelvin Wai Kwok Yeung, Kenneth Man Chee Cheung, Keith Dip Kei Luk, Che Yan Yeung, Richard Yi Tsun Kao, Paul Kim Ho Chu
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Patent number: 7677249Abstract: The present invention relates generally to a device and method for providing a lateralization effect such as in a medical procedure. The lateralization device can have a supporting member, which can be adapted to be supported in a fixed position. A lateralization member can be provided to at least partially wrap around the supporting member and be mounted thereto to provide a lateralization effect. The lateralization member can be formed and/or adjusted to provide a variable lateralization. For example, the lateralization member can comprise a cylindrical member with an eccentric cut-out portion adapted to fit over the supporting member. The inter wall of the cut-out portion and the outer wall of the supporting member can be formed with interference fittings so that the lateralization member can rotate in relation to the supporting member to provide a variable lateralization.Type: GrantFiled: April 14, 2004Date of Patent: March 16, 2010Assignee: The University of Hong KongInventors: James Kam Fu Kong, Eric Ping Chien, Keith Dip Kei Luk
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Publication number: 20080027551Abstract: A natural spinal disk including adjacent vertebral structures is removed from a deceased donor, rinsed in normal saline, preserved in a cryopreservative solution, and then frozen by gradually decreasing the temperature using liquid nitrogen or similar method. The implant may be thawed in normal saline solution and then implanted in a patient in need of a vertebral disk replacement.Type: ApplicationFiled: June 27, 2007Publication date: January 31, 2008Inventors: Keith Dip Kei Luk, Dike Ruan
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Publication number: 20040260299Abstract: The present invention relates generally to a device and method for providing a lateralization effect such as in a medical procedure. The lateralization device can have a supporting member, which can be adapted to be supported in a fixed position. A lateralization member can be provided to at least partially wrap around the supporting member and be mounted thereto to provide a lateralization effect. The lateralization member can be formed and/or adjusted to provide a variable lateralization. For example, the lateralization member can comprise a cylindrical member with an eccentric cut-out portion adapted to fit over the supporting member. The inter wall of the cut-out portion and the outer wall of the supporting member can be formed with interference fittings so that the lateralization member can rotate in relation to the supporting member to provide a variable lateralization.Type: ApplicationFiled: April 14, 2004Publication date: December 23, 2004Inventors: James Kam Fu Kong, Eric Ping Chien, Keith Dip Kei Luk