Patents by Inventor Keith E. Langley

Keith E. Langley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metalloproteinase inhibitor
    Patent number: 7994136
    Abstract: A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed.
    Type: Grant
    Filed: May 19, 1989
    Date of Patent: August 9, 2011
    Assignee: Amgen Inc.
    Inventors: Keith E. Langley, Yves A. DeClerck, Thomas C. Boone
  • Methods for detecting metalloproteinase inhibitors
    Patent number: 7553630
    Abstract: A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed.
    Type: Grant
    Filed: July 19, 2004
    Date of Patent: June 30, 2009
    Assignees: Amgen Inc., Childrens Hospital Los Angeles
    Inventors: Keith E. Langley, Yves A. DeClerck, Thomas C Boone
  • Metalloproteinase inhibitor
    Patent number: 6946264
    Abstract: A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed.
    Type: Grant
    Filed: March 2, 1995
    Date of Patent: September 20, 2005
    Assignees: Amgen Inc., Childrens Hospital Los Angeles Research Institute
    Inventors: Keith E. Langley, Yves A. DeClerck, Thomas C. Boone
  • Conjugated ligands for the stimulation of blood cell proliferation by effecting dimerization of the receptor for stem cell factor
    Patent number: 6904369
    Abstract: This invention provides a computer based method for preparing a stem cell factor (SCF) analog comprising the steps of: (a) providing computer expression of the three dimensional structure of an SCF molecule using its crystal structure; (b) selecting from the computer expression of step (a) at least one site on the SCF molecule for alteration; (c) preparing a SCF molecule having an alteration at said at least one selected site; and (d) optionally, testing the SCF molecule for a desired characteristic. This invention also provides SCF analogs and SCF ligand analogs prepared according to the above-described method. Compositions comprising SCF analogs or SCF ligand analogs prepared according to the above-described method effective to treat a subject and a pharmaceutically acceptable carrier are provided, as are methods of treating a subject comprising administration of pharmaceutical compositions comprising the prepared SCF analogs and SCF ligand analogs prepared by the described methods.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: June 7, 2005
    Assignees: The Trustees of Columbia University in the City of New York, Amgen Inc.
    Inventors: Wayne A. Hendrickson, Xuliang Jiang, Keith E. Langley, Rashid Syed, Yueh-Rong Ann Hsu
  • Antibodies to the metalloproteinase inhibitor
    Patent number: 6849450
    Abstract: A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: February 1, 2005
    Assignees: Childrens Hospital of Los Angeles, Amgen Inc.
    Inventors: Keith E. Langley, Yves A. DeClerck, Thomas C. Boone
  • METALLOPROTEINASE INHIBITOR
    Publication number: 20020090654
    Abstract: A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed.
    Type: Application
    Filed: February 21, 1997
    Publication date: July 11, 2002
    Inventors: KEITH E. LANGLEY, YVES A. DECLERCK, THOMAS C. BOONE
  • Method of inhibiting tumor cell dissemination with a metalloproteinase inhibitor
    Patent number: 5714465
    Abstract: A novel metalloproteinase inhibitor, analogs thereof, polynucleotides encoding the same, and methods of production, are disclosed. Pharmaceutical compositions and methods of treating disorders caused by excessive amounts of metalloproteinase are also disclosed. In particular, a method for inhibiting tumor cell dissemination in a mammal comprising administering an effective amount of such metalloproteinase inhibitors is described.
    Type: Grant
    Filed: March 11, 1994
    Date of Patent: February 3, 1998
    Assignee: Amgen Inc.
    Inventors: Keith E. Langley, Yves A. DeClerck, Thomas C. Boone