Abstract: The disclosure provides pharmaceutical compositions comprising a stabilized pharmaceutically acceptable salt of apilimod, and one or more pharmaceutically acceptable excipients, and related compositions and methods for their use in treating neurodegenerative diseases or disorders, cancer, and viral infections.

Abstract: In order to avoid cavitation in a boom cylinder head end at the beginning of a dig cycle, fluid from an alternate source is supplied to the head end before or in addition to fluid supplied by the main boom-up hydraulic circuit. In one embodiment, an electronic hydraulic valve, related sensors, and control system determines the beginning of a dig operation and uses fluid at an intermediate pressure to rapidly provide fluid to a boom head end cylinder to prevent voiding or cavitation before fluid under high pressure from the main pump can be brought to the cylinder. An on/off fluid switch is activated early in a dig operation to address low pressure at the boom cylinder head end and provide an alternate path for fluid into the cylinder in reaction to the boom being lifted by a motion of the stick and bucket in contact with the work surface.

Abstract: In order to avoid cavitation in a boom cylinder head end at the beginning of a dig cycle, fluid from an alternate source is supplied to the head end before or in addition to fluid supplied by the main boom-up hydraulic circuit. In one embodiment, an electronic hydraulic valve, related sensors, and control system determines the beginning of a dig operation and uses fluid at an intermediate pressure to rapidly provide fluid to a boom head end cylinder to prevent voiding or cavitation before fluid under high pressure from the main pump can be brought to the cylinder. An on/off fluid switch is activated early in a dig operation to address low pressure at the boom cylinder head end and provide an alternate path for fluid into the cylinder in reaction to the boom being lifted by a motion of the stick and bucket in contact with the work surface.

Abstract: A variable compression ratio mechanism for an internal combustion engine that has an engine block and a crankshaft is disclosed. The variable compression ratio mechanism has a plurality of eccentric disks configured to support the crankshaft. Each of the plurality of eccentric disks has at least one cylindrical portion annularly surrounded by the engine block. The variable compression ratio mechanism also has at least one actuator configured to rotate the plurality of eccentric disks.

Abstract: A fuel injector includes an injector body and a three-way control valve having a valve element movable between first and second positions in the injector body. A check is disposed in the injector body and is movable to inject fuel when the control valve is in the second position and to block fuel injection when the control valve is in the first position. An actuator is selectively operable to move the valve element between the first and second positions. The injector includes a single clearance fit located in the control valve wherein the clearance fit is not exposed to a substantial pressure differential when the control valve is in the first position.