Abstract: A system, method, and computer-readable medium to deliver patient reported outcomes and therapeutic recommendations to patients with immunotherapy. Management of adverse events in the treatment of patients implementing a digital therapeutic(s) that enforces a digital care pathway that receives patient data of answers to machine generated questions and patient symptoms, where the patient data is consumed by digital care pathway. The patient data is process with digital therapeutics (DTx) knowledge models that influence the digital care pathway. Recommendations are provided based on the processed data.