Patents by Inventor Keith Gagnon

Keith Gagnon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tuning CRISPR/Cas9 activity with chemically modified nucleotide substitutions
    Patent number: 11306305
    Abstract: The present disclosure provides CRISPR/Cas9 ribonucleoprotein compositions comprising chemically modified CRISPR RNA (crRNA) guide and trans-acting CRISPR RNA (tracrRNA) components. Methods of using the disclosed CRISPR/Cas9 ribonucleoprotein compositions are also provided.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: April 19, 2022
    Assignees: Board of Trustees of Southern Illinois University
    Inventors: Keith Gagnon, Masad Damha, Elise Malek-Adamian, Maryam Habibian, Daniel Timothy O'Reilly, Zachery Kartje
  • Tuning CRISPR/CAS9 Activity with Chemically Modified Nucleotide Substitutions
    Publication number: 20190185844
    Abstract: The present disclosure provides CRISPR/Cas9 ribonucleoprotein compositions comprising chemically modified CRISPR RNA (crRNA) guide and trans-acting CRISPR RNA (tracrRNA) components. Methods of using the disclosed CRISPR/Cas9 ribonucleoprotein compositions are also provided.
    Type: Application
    Filed: September 22, 2017
    Publication date: June 20, 2019
    Applicants: Board of Trustees of Southern lllinois University, The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Keith GAGNON, Masad DAMHA, Elise MALEK-ADAMIAN, Maryam HABIBIAN, Daniel O'REILLY, Zachery KARTJE
  • THIN FILM WITH MICROCHANNELS
    Publication number: 20160303283
    Abstract: A scaffold, a method of using the scaffold and a method of preparing the scaffold which may promote the growth or survival of cells and tissues. The scaffold comprises at least one microvascular layer formed from a thin-film fibrin, the microvascular layer configured to sustain and promote growth of cells and having one or more microfluidics channels embedded in the microvascular layer, the channels configured to contain nutrients needed for growth of the cells, and the channels configured to permit diffusion of the nutrients from the channels to the cells.
    Type: Application
    Filed: April 15, 2016
    Publication date: October 20, 2016
    Inventors: Keith A. Gagnon, Thomas J. Moutinho, JR., Kevin A. Reyer, Alyssa L. Bornstein, Megan O'Brien, George D. Pins, Glenn R. Gaudette
  • METHODS AND COMPOSITIONS USEFUL IN TREATMENT OF DISEASES OR CONDITIONS RELATED TO REPEAT EXPANSION
    Publication number: 20130059902
    Abstract: The present invention is drawn to chemically-modified oligomers that are complementary to, and capable of hybridizing within the repeat region of CAG, CUG, or CCUG nucleotide repeat-containing RNAs (NRRs).
    Type: Application
    Filed: February 8, 2011
    Publication date: March 7, 2013
    Applicant: Isis Pharmaceuticals, Inc.
    Inventors: David Corey, C. Frank Bennett, Eric E. Swayze, Keith Gagnon