Patents by Inventor Keith Garrison

Keith Garrison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of inducing a T lymphocyte response using T-cell immunogens derived from anti-viral proteins
    Patent number: 9572873
    Abstract: Isolated polypeptides related to endogenous anti-viral polypeptides; and compositions, including immunogenic compositions, comprising a subject isolated polypeptide are disclosed herein. A subject isolated polypeptide comprises an amino acid sequence having substantial amino acid sequence identity to a contiguous stretch of amino acids of one or more endogenous anti-viral polypeptides, wherein the endogenous anti-viral polypeptides are polypeptides subject to proteolytic degradation as a result of the activity of one or more viral proteins. Also provided are diagnostic and treatment methods using the subject isolated polypeptides and compositions.
    Type: Grant
    Filed: July 7, 2015
    Date of Patent: February 21, 2017
    Assignee: The Regents of the University of California
    Inventors: Douglas F. Nixon, Stephane Champiat, Keith Garrison
  • T-CELL IMMUNOGENS DERIVED FROM ANTI-VIRAL PROTEINS AND METHODS OF USING SAME
    Publication number: 20160151470
    Abstract: Isolated polypeptides related to endogenous anti-viral polypeptides; and compositions, including immunogenic compositions, comprising a subject isolated polypeptide are disclosed herein. A subject isolated polypeptide comprises an amino acid sequence having substantial amino acid sequence identity to a contiguous stretch of amino acids of one or more endogenous anti-viral polypeptides, wherein the endogenous anti-viral polypeptides are polypeptides subject to proteolytic degradation as a result of the activity of one or more viral proteins. Also provided are diagnostic and treatment methods using the subject isolated polypeptides and compositions.
    Type: Application
    Filed: July 7, 2015
    Publication date: June 2, 2016
    Inventors: Douglas F. Nixon, Stephane Champiat, Keith Garrison
  • T-cell immunogens derived from anti-viral proteins and methods of using same
    Patent number: 9084762
    Abstract: Isolated polypeptides related to endogenous anti-viral polypeptides; and compositions, including immunogenic compositions, comprising a subject isolated polypeptide are disclosed herein. A subject isolated polypeptide comprises an amino acid sequence having substantial amino acid sequence identity to a contiguous stretch of amino acids of one or more endogenous anti-viral polypeptides, wherein the endogenous anti-viral polypeptides are polypeptides subject to proteolytic degradation as a result of the activity of one or more viral proteins. Also provided are diagnostic and treatment methods using the subject isolated polypeptides and compositions.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: July 21, 2015
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Douglas F. Nixon, Stephane Champiat, Keith Garrison
  • T-Cell Immunogens Derived from Anti-Viral Proteins and Methods of Using Same
    Publication number: 20110274709
    Abstract: Isolated polypeptides related to endogenous anti-viral polypeptides; and compositions, including immunogenic compositions, comprising a subject isolated polypeptide are disclosed herein. A subject isolated polypeptide comprises an amino acid sequence having substantial amino acid sequence identity to a contiguous stretch of amino acids of one or more endogenous anti-viral polypeptides, wherein the endogenous anti-viral polypeptides are polypeptides subject to proteolytic degradation as a result of the activity of one or more viral proteins. Also provided are diagnostic and treatment methods using the subject isolated polypeptides and compositions.
    Type: Application
    Filed: September 28, 2009
    Publication date: November 10, 2011
    Inventors: Douglas F. Nixon, Stephane Champiat, Keith Garrison
  • Long Interspersed Nuclear Element Polypeptide Compositions and Methods of Use Thereof
    Publication number: 20110046042
    Abstract: The present invention provides LINE polypeptides; and compositions, including immunogenic compositions, comprising a subject LINE polypeptide. The present invention provides a recombinant nucleic acid comprising a nucleotide sequence encoding a subject LINE polypeptide. A subject composition is useful for stimulating a T-cell immune response to a LINE peptide. The present invention further provides methods of stimulating an immune response in an individual to a retrovirus- or lentivirus-infected cell. The present invention further provides methods of treating cancers that are associated with tissues in which LINE polypeptides are aberrantly expressed. Also provided are methods of treating disorders, involving decreasing an immune response to a LINE polypeptide.
    Type: Application
    Filed: September 19, 2008
    Publication date: February 24, 2011
    Applicants: THE J. DAVID GLADSTONE INSTITUTES, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Douglas F. Nixon, Keith Garrison, Duncan Meiklejohn, Mario Ostrowski, R. Bradley Jones, Ashish Agrawal, Frederick M. Hecht
  • Human endogenous retrovirus polypeptide compositions and methods of use thereof
    Publication number: 20080171061
    Abstract: The present invention provides isolated HERV polypeptides; and compositions, including immunogenic compositions, comprising a HERV polypeptide. The present invention provides immunogenic compositions comprising a nucleic acid comprising a nucleotide sequence encoding a HERV polypeptide. The immunogenic compositions are useful for stimulating a T cell immune response to a lentiviral peptide. The present invention further provides methods of stimulating an immune response in an individual to a retrovirus- or lentivirus-infected cell. The present invention further provides methods of treating cancers in which HERV polypeptides are expressed. Also provided are methods of treating disorders, involving decreasing an immune response to a HERV polypeptide.
    Type: Application
    Filed: July 19, 2007
    Publication date: July 17, 2008
    Inventors: Douglas Nixon, Keith Garrison, Duncan Meiklejohn, Mario Ostrowski, R. Bradley Jones, Ashish Agrawal, Jack Lenz, Seth Rakoff-Nahoum, Frederick M. Hecht