Patents by Inventor Keith H. Ansell

Keith H. Ansell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND MEANS FOR SCREENING FOR RHOMBOID ACTIVITY
    Publication number: 20090156457
    Abstract: This invention relates to methods of screening for rhomboid modulating compounds using a substrate polypeptide has a core domain comprising a rhomboid cleavable TMD sequence linked to an upstream tag sequence. The core domain sequence is not susceptible to cleavage by non-rhomboid proteases so products of rhomboid dependent proteolysis products may be detected by determining the presence of the tag sequence. Rhomboid modulating compounds identified by the present methods may be useful in a range of therapeutic applications.
    Type: Application
    Filed: January 17, 2005
    Publication date: June 18, 2009
    Applicant: MEDICAL RESEARCH COUNCIL
    Inventor: Keith H. Ansell
  • Anti-EGFR single-chain Fvs and anti-EGFR antibodies
    Patent number: 5844093
    Abstract: This invention relates to new anti-EGFR antibodies and single-chain Fvs (scFvs) thereof which can be obtained from phage-antibody libraries constructed from cells of an immunized mammalian, preferably a mouse. Two of the single-chain Fvs isolated from the phage-antibody libraries were engineered to create partially humanized whole antibody molecules. These chimeric anti-EGFR antibodies contain constant regions of human immunoglobulins, and can be used as well as the single-chain Fvs as agents for the diagnosis and therapy of human tumors.
    Type: Grant
    Filed: November 17, 1995
    Date of Patent: December 1, 1998
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: A. Cathrine Kettleborough, Mary M. Bendig, Keith H. Ansell, Detlef Gussow, Jaume Adan, Francesc Mitjans, Elisabet Rosell, Francesc Blasco, Jaume Piulats