Patents by Inventor Keith H. Baggaley

Keith H. Baggaley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Clavam derivatives and its enzymatic preparation
    Patent number: 5130241
    Abstract: A compound having the formula (I): ##STR1## is described, together with salts thereof and an enzymatic process for converting such compounds into clavulanic acid.A process for the preparation of the compound of formula (I) and its salts is disclosed, together with intermediates for use therein. This process involves the use of a novel enzyme system to effect the desired cyclisation, which enzyme system is preferably derived from a micro-organism, in particular a species of Streptomyces.
    Type: Grant
    Filed: December 26, 1990
    Date of Patent: July 14, 1992
    Assignee: Beecham Group plc
    Inventors: Stefan R. Woroniecki, Stephen W. Elson, Keith H. Baggaley
  • Novel clavam derivatives and methods of making same
    Patent number: 4795809
    Abstract: A compound having the formula (I): ##STR1## is described, together with salts thereof and an enzymatic process for converting such compounds into clavulanic acid.A process for the preparation of the compound of formula (I) and its salts is disclosed, together with intermediates for use therein. This process involves the use of a novel enzyme system to effect the desired cyclization, which enzyme system is preferably derived from a micro-organism, in particular a species of Streptomyces.
    Type: Grant
    Filed: August 27, 1986
    Date of Patent: January 3, 1989
    Assignee: Beecham Group plc
    Inventors: Stefan R. Woroniecki, Stephen W. Elson, Keith H. Baggaley
  • Hypolipidaemic compounds
    Patent number: 4362892
    Abstract: Certain substituted aralkylanilines in which the aromatic aniline ring carries, at the para position to the amino function, a substituent which comprises a carboxylic acid, salt or ester, an alkyl, hydroxyalkyl, cyano or acyl group, have hypolipidaemic activity.
    Type: Grant
    Filed: December 12, 1977
    Date of Patent: December 7, 1982
    Assignee: Beecham Group Limited
    Inventors: Richard M. Hindley, Keith H. Baggaley
  • Method of inhibiting platelet aggregation
    Patent number: 4350702
    Abstract: A class of 2-substituted benzisothiazolones carrying a nitrogen-containing heterocyclic ring are effective in inhibiting platelet aggregation and are therefore of value in the prophylactic and therapeutic treatment of thrombotic diseases.
    Type: Grant
    Filed: October 31, 1980
    Date of Patent: September 21, 1982
    Assignee: Beecham Group Limited
    Inventor: Keith H. Baggaley
  • Prostacyclin aza analogue intermediates
    Patent number: 4341708
    Abstract: An intermediate compound which is a perhydrofuro [3,2-6] pyrrole of the formula: ##STR1## wherein: R.sub.2 is hydrogen or C.sub.1-4 alkyl; andR.sub.3 is C.sub.4-9 alkyl, C.sub.5-7 cycloalkyl or C.sub.5-7 cycloalkyl C.sub.1-6 alkyl;for use in the synthesis of prostacyclin aza analogues having anti-thrombotic activity.
    Type: Grant
    Filed: February 2, 1981
    Date of Patent: July 27, 1982
    Assignee: Beecham Group Limited
    Inventors: Frederick Cassidy, Keith H. Baggaley, Arthur W. R. Tyrrell
  • 2,4-Disubstituted 5-oxo-5H-hexahydrofuro[3,2b]pyrroles
    Patent number: 4262008
    Abstract: A compound of formula (I): ##STR1## wherein: A is >CH-- and n is 1 to 6; orA is >C.dbd.CH-- and n is 0 to 5; orA is >CH--CH.dbd.CH and n is 0 to 4; andR.sub.1 is hydrogen or C.sub.1-6 alkyl;R.sub.2 is hydrogen or C.sub.1-4 alkyl; andR.sub.3 is C.sub.4-9 alkyl, C.sub.5-7 cycloalkyl or C.sub.5-7 cycloalkyl-C.sub.1-6 alkyl; and salts thereof, has antiplatelet aggregation and bronchodilation activity.
    Type: Grant
    Filed: October 9, 1979
    Date of Patent: April 14, 1981
    Assignee: Beecham Group Limited
    Inventors: Frederick Cassidy, Keith H. Baggaley, Arthur W. R. Tyrrell
  • 2-Substituted benzisothiazolones
    Patent number: 4243669
    Abstract: A class of 2-substituted benzisothiazolones carrying a nitrogen-containing heterocyclic ring are effective in inhibiting platelet aggregation and are therefore of value in the prophylactic and therapeutic treatment of thrombotic diseases.
    Type: Grant
    Filed: August 20, 1979
    Date of Patent: January 6, 1981
    Assignee: Beecham Group Limited
    Inventor: Keith H. Baggaley
  • 2-Substituted benzisothiazolones and use thereof
    Patent number: 4212872
    Abstract: A class of 2-substituted benzisothiazolones carrying a nitrogen-containing heterocyclic ring are effective in inhibiting platelet aggregation and are therefore of value in the prophylactic and therapeutic treatment of thrombotic diseases.
    Type: Grant
    Filed: August 25, 1978
    Date of Patent: July 15, 1980
    Assignee: Beecham Group Limited
    Inventor: Keith H. Baggaley
  • 2-Substituted benzisothiazolones
    Patent number: 4212979
    Abstract: A class of 2-substituted benzisothiazolones carrying a nitrogen-containing heterocyclic ring are effective in inhibiting platelet aggregation and are therefore of value in the prophylactic and therapeutic treatment of thrombotic diseases.
    Type: Grant
    Filed: November 11, 1977
    Date of Patent: July 15, 1980
    Assignee: Beecham Group Limited
    Inventor: Keith H. Baggaley
  • Hypolipidaemic compounds and compositions
    Patent number: 4206145
    Abstract: Certain substituted aralkylanilines in which the aromatic aniline ring carries, at the para position to the amino function, a substituent which comprises a carboxylic acid, salt or ester, an alkyl, hydroxyalkyl, cyano or acyl group, have hypolipidaemic activity.
    Type: Grant
    Filed: December 12, 1977
    Date of Patent: June 3, 1980
    Assignee: Beecham Group Limited
    Inventors: Richard M. Hindley, Keith H. Baggaley
  • 2-[Gamma-(1-piperidinyl)propyl]-1,2-benzisothiazole-3-one, its salts, and pharmaceutical compositions
    Patent number: 4186203
    Abstract: The compound 2-[gamma-(1-piperidinyl)propyl]-1,2-benzisothiazole-3-one or a pharmaceutically acceptable acid addition salt thereof and pharmaceutical compositions containing an effective amount of such compound or salt and a carrier, preferably compositions in orally administrable form. The compound or salt is characterized by antithrombotic activity, especially for inhibiting platelet aggregation. Procedures for preparation of the compound are described.
    Type: Grant
    Filed: June 19, 1978
    Date of Patent: January 29, 1980
    Assignee: Beecham Group Limited
    Inventors: Barbara Nunn, Keith H. Baggaley
  • Prophylaxis or treatment of thromboses and inhibition of platelet aggregation in human blood
    Patent number: 4182768
    Abstract: A method for the prophylaxis or treatment of thromboses in humans which comprises administering to a human in need thereof a therapeutically effective amount of a compound of the formula (II) ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein R is 1-piperidyl or 1-pyrrolidyl. Compounds of the formula (II) are also useful for the inhibition of platelet aggregation in vitro or in vivo.
    Type: Grant
    Filed: May 30, 1978
    Date of Patent: January 8, 1980
    Assignee: Beecham Group Limited
    Inventors: Barbara Nunn, Keith H. Baggaley
  • Certain di-(substituted phenoxy) alkanes and hypolipidaemic use thereof
    Patent number: 4154850
    Abstract: A class of di-(substituted phenoxy) alkanes having from 7 to 25 carbon atoms in the alkane moiety have hypolipidaemic activity.
    Type: Grant
    Filed: August 4, 1977
    Date of Patent: May 15, 1979
    Assignee: Beecham Group Limited
    Inventors: Brian Morgan, Keith H. Baggaley, Richard M. Hindley