Abstract: Methods and compositions for treating 25-hydroxyvitamin D insufficiency and deficiency in a patient are described herein. The method includes orally administering to the patient a delayed, sustained release formulation including a first ingredient selected from the group consisting of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, or a combination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, or it includes gradually administering to the patient a sterile intravenous formulation including a first ingredient selected from the group consisting of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, or a combination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3.

Abstract: A spraying apparatus is disclosed which employs a manually operable pump adapted to discharge a dosage of a liquid, such as a pharmaceutical preparation, from an associated container. The pump includes a reciprocating stem which extends through a screw cap of the container. An actuator is mounted on the stem of the pump for conjoint reciprocating movement therewith relative to the screw cap. Upon the extension of the actuator and hence the stem, liquid is withdrawn from the container by the pump. Upon the depression of the actuator and hence the stem, the liquid is delivered to a spray nozzle formed integrally with the actuator and then discharged from the nozzle in the form of a spray or mist. In order to ensure the smooth and effective operation of the spraying apparatus, lugs on the actuator cooperate with ribs on the screw cap to inhibit the actuator from rocking on the stem as the actuator is depressed.