Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: The disclosure describes methods of synthesis of pyridazinone compounds as thyroid hormone analogs and their prodrugs. Preferred methods according to the disclosure allow for large-scale preparation of pyridazinone compounds having high purity. In some embodiments, preferred methods according to the disclosure also allow for the preparation of pyridazinone compounds in better yield than previously used methods for preparing such compounds. Also disclosed are morphic forms of a pyridazinone compound. Further disclosed is a method for treating resistance to thyroid hormone in a subject having at least one TR? mutation.

Abstract: Dosage forms or pharmaceutical compositions comprise a compound having the structure of Formula IV: wherein n is a non-negative integer; wherein each Z is an oxazolidinone-containing moiety having antibiotic activity in vivo upon cleaving, wherein M is independently OR1 or NR1R2; wherein R1 and R2 are independently selected from the group consisting of H, an optionally-substituted hydrocarbyl residue or a pharmaceutically acceptable cation; wherein the compound in the dosage form or a pharmaceutical composition is present in an amount effective for treating or preventing an antibacterial infection in a mammalian subject. Methods of preparing and using these dosage forms or pharmaceutical compositions are also disclosed.

Abstract: Dosage forms or pharmaceutical compositions comprise a compound having the structure of Formula IV: wherein n is a non-negative integer; wherein each Z is an oxazolidinone-containing moiety having antibiotic activity in vivo upon cleaving, wherein M is independently OR1 or NR1R2; wherein R1 and R2 are independently selected from the group consisting of H, an optionally-substituted hydrocarbyl residue or a pharmaceutically acceptable cation; wherein the compound in the dosage form or a pharmaceutical composition is present in an amount effective for treating or preventing an antibacterial infection in a mammalian subject. Methods of preparing and using these dosage forms or pharmaceutical compositions are also disclosed.

Abstract: Dosage forms or pharmaceutical compositions comprise a compound having the structure of Formula IV: wherein n is a non-negative integer; wherein each Z is an oxazolidinone-containing moiety having antibiotic activity in vivo upon cleaving, wherein M is independently OR1 or NR1R2; wherein R1 and R2 are independently selected from the group consisting of H, an optionally-substituted hydrocarbyl residue or a pharmaceutically acceptable cation; wherein the compound in the dosage form or a pharmaceutical composition is present in an amount effective for treating or preventing an antibacterial infection in a mammalian subject. Methods of preparing and using these dosage forms or pharmaceutical compositions are also disclosed.

Abstract: Alerts are targeted for display at an information handling system by associating conditions with alerts and downloading for display an alert only to information handling systems that meet the conditions of the alert. An alert list that includes alerts and associated conditions in an Extensible Mark-up Language file is periodically queried for retrieval at information handling systems and parsed to determine alerts targeted to the information handling system. Only relevant alerts are downloaded and displayed at each information handling system to minimize user distraction. Specific targeting is provided by logical expressions that may state conditional alert configuration parameters with precision to limit the number of information handling systems targeted for the alert to very specific configurations.

Abstract: Information handling system consumable orders, such as orders for printer supplies, are placed through a network, such as the Internet, by automatically monitoring consumable quantity to detect a consumable order trigger event for presentation at the information handling system. User initiated selection of a consumable order communicates order information to a consumable order server, which pre-populates a completed order form for display at the information handling system, such as an order form with consumable information, payment information and delivery information. For instance, the consumable order server is associated with the manufacturer of the information handling system and applies the payment and delivery information from the purchase of the information handling system to complete the order form so that a user need only confirm the accuracy of the completed order form to place the consumable order.

Abstract: A method and system are provided which substantially reduce the disadvantages and problems associated with previous methods and systems for resolving issues related to information handling system failures. A self-support application on an information handling system diagnoses failure issues not correctable by self-support and communicates a diagnostic code through a network to a service center. The service center determines the failure issue from the diagnostics code and refers the failure issue to an issue resolution source associated with resolution of the failure issue, such as automated support resolution for failure issues having a known resolution, or phone or electronic message support for failure issues not having a known resolution.

Abstract: Alerts are targeted for display at an information handling system by associating conditions with alerts and downloading for display an alert only to information handling systems that meet the conditions of the alert. An alert list that includes alerts and associated conditions in an Extensible Mark-up Language file is periodically queried for retrieval at information handling systems and parsed to determine alerts targeted to the information handling system. Only relevant alerts are downloaded and displayed at each information handling system to minimize user distraction. Specific targeting is provided by logical expressions that may state conditional alert configuration parameters with precision to limit the number of information handling systems targeted for the alert to very specific configurations.

Abstract: Direct marketing subsystems associated with information handling systems download coupon lists from a direct marketing server, each coupon of a coupon list having one or more associated conditions and items offered for sale. A coupon relevance module analyzes the coupon list conditions to identify coupons that are relevant to the information handling system for display at the information handling system. Activation of a coupon initiates purchase of the item associated with the coupon by communication with the direct marketing server. A unique identifier of the information handling system associates selection of the coupon with an account for charging and delivery of the purchased item.