Abstract: A negative-pressure-resistible leakage-proof bottle cover, wherein a leakage-proof gasket is disposed. A circular main body of the leakage-proof gasket is stuck onto inner top face of a cover body, wherein an extended positioning circumferential edge is commensurate with a confining stopper of the cover body. The bottom face of the leakage-proof gasket is extended to form an infiltration resister, whereof the open end is further extended in out- and- up direction to form an infiltration-resisting ring. At a lower portion of the cover body, an anti-tampering ring is arranged, wherein a plurality of seamless cutting lines is round-set and a bridge point is formed in each of the seamless cutting lines.