Patents by Inventor Keith Hopkinson Gibson
Keith Hopkinson Gibson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 7897778Abstract: The invention concerns benzamide compounds of Formula (I), wherein R1a, R1b, R1c, R2, R3, R4, m and n have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of histone deacetylase (HDAC).Type: GrantFiled: August 31, 2005Date of Patent: March 1, 2011Assignee: AstraZenecaInventors: Keith Hopkinson Gibson, Elaine Sophie Elizabeth Stokes, Michael James Waring, David Michael Andrews, Zbigniew Stanley Matusiak, Mark Andrew Graham
-
Publication number: 20100075942Abstract: The invention concerns benzamide derivatives of Formula (I) wherein R1a, R1b, R1c, R2, R3, R4, W, m and n have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of histone deacetylase (HDAC).Type: ApplicationFiled: January 12, 2006Publication date: March 25, 2010Applicant: ASTRAZENECA ABInventors: Keith Hopkinson Gibson, Elaine Sophie, Elizabeth Stokes, Michael James Waring, David Michael Andrews, Zbigniew Stanley Matusiak, Mark Maybury, Craig Anthony Roberts
-
Patent number: 7504408Abstract: The invention concerns quinazoline derivatives of Formula (I) wherein each of Z, m, R1, n, R3, Z2 and R14 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive or anti-proliferative agent in the containment and/or treatment of solid tumour disease.Type: GrantFiled: July 4, 2003Date of Patent: March 17, 2009Assignee: AstraZeneca ABInventors: Laurent Francois Andre Hennequin, Keith Hopkinson Gibson, Kevin Michael Foote
-
Patent number: 7504416Abstract: The invention concerns compounds of formula (I), wherein each of R1, R2, R3, R4, R5, R6, R8, R9, R10 m, n, p, X, Y and Z have any meanings defined in the description, processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-proliferative agent in the treatment of solid tumor disease.Type: GrantFiled: July 16, 2007Date of Patent: March 17, 2009Assignee: AstraZeneca ABInventors: Francis Thomas Boyle, Keith Hopkinson Gibson
-
Publication number: 20080293687Abstract: The invention concerns benzamide compounds of Formula (I), wherein R1a, R1b, R1c, R2, R3, R4, m and n have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of histone deacetylase (HDAC).Type: ApplicationFiled: August 31, 2005Publication date: November 27, 2008Inventors: Keith Hopkinson Gibson, Elaine Sophie Elizabeth Stokes, Michael James Waring, David Michael Andrews, Zbigniew Stanley Matusiak, Mark Andrew Graham
-
Patent number: 7402583Abstract: The invention provides a compound of Formula (Ia), or a pharmaceutically acceptable salt thereof, a process for t he preparation of a compound of Formula (1a) and pharmaceutical compositions of a compound of Formula (1a).Type: GrantFiled: March 14, 2006Date of Patent: July 22, 2008Assignee: AstrZenca ABInventors: Francis Thomas Boyle, Keith Hopkinson Gibson, Kevin Michael Foote
-
Publication number: 20080119451Abstract: The invention concerns benzamide derivatives of Formula (I) wherein R1a, R1b, R1c, R2, R3, R4, integer m, integer n and W have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of histone deacetylase (HDAC).Type: ApplicationFiled: January 17, 2006Publication date: May 22, 2008Applicant: ASTRAZENECA ABInventors: Keith Hopkinson Gibson, Elaine Sophie Elizabeth Stokes, Michael James Waring, David Michael Andrews, Zbigniew Stanley Matusiak
-
Patent number: 7253184Abstract: The invention concerns compounds of formula (I), wherein each of R1, R2, R3, R4, R5, R6, R8, R9, R10 m, n, p, X, Y and Z have any meanings defined in the description, processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-proliferative agent in the treatment of solid tumour disease.Type: GrantFiled: October 25, 2001Date of Patent: August 7, 2007Assignee: AstraZeneca ABInventors: Francis Thomas Boyle, Keith Hopkinson Gibson
-
Patent number: 7173135Abstract: The invention concerns quinoline derivatives of Formula (I) wherein each of Z1, m, R1, n, R3, Z2 and R14 have any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive or anti-proliferative agent in the containment and/or treatment of solid tumour disease.Type: GrantFiled: July 4, 2003Date of Patent: February 6, 2007Assignee: AstraZeneca ABInventors: Laurent Francois Andre Hennequin, Keith Hopkinson Gibson, Kevin Michael Foote
-
Patent number: 7067532Abstract: The invention provides a compound of Formula (Ia), or a pharmaceutically acceptable salt pro-drug or solvate thereof. The invention also provides a process for the preparation of a compound of Formula (Ia), pharmaceutical compositions of a compound of Formula (Ia) and methods for the treatment or prevention of cancer comprising administering an effective amount of a compound of Formula (Ia).Type: GrantFiled: October 26, 2001Date of Patent: June 27, 2006Assignee: AstraZenecaInventors: Francis Thomas Boyle, Keith Hopkinson Gibson, Kevin Michael Foote
-
Patent number: 6809106Abstract: A compound of formula (I) or a pharmaceutically acceptable salt thereof; for use as a medicament wherein: n is 0-1; Y is selected from —NH—, —O—, —S—, or —NR7— where R7 is alkyl of 1-6 carbon atoms R5 is chloro or bromo; Y is selected from —NH—, —O—, —S—, or —NR7— where R7 is alkyl of 1-6 carbon atoms R6 is a specified cyclic group which may be substituted by various specified substituents, or R6 is a group —R8—X—R9 where R8 is selected from various cycloalkyl, pyridinyl, pyimidinyl, or phenyl ring; any of which may be optionally subsituted as described, where X is selected from CH2, —NH—, —O—, —S—, CH2 or —NR5— where R5 is alkyl of 1-6 carbon atoms, and R9 is a group (CH2)mR10 where m is 0, or an integer of from 1-3 and R10 is an optionally substituted aryl or optionally substituted cycloalkyl ring of up to 10 carbon atoms,Type: GrantFiled: October 17, 2001Date of Patent: October 26, 2004Assignee: AstraZeneca ABInventor: Keith Hopkinson Gibson
-
Publication number: 20040029898Abstract: The invention provides a compound of Formula (Ia), or a pharmaceutically acceptable salt. prodrug or solvate thereof. The invention also provides a process for the preparation of a compound of Formula (Ia), pharmaceutical compositions of a compound of Formula (Ia) and methods for the treatment or prevention of cancer comprising administering an effective amount of a compound of Formula (Ia).Type: ApplicationFiled: May 2, 2003Publication date: February 12, 2004Inventors: Francis Thomas Boyle, Keith Hopkinson Gibson, Kevin Michael Foote
-
Patent number: 6638945Abstract: A compound formula (I) or a pharmaceutically acceptable salt thereof, for use in the manufacture of a medicament for inhibition of MEK in a mammal with a MEK mediated disease wherein: n is 0-1; Y is selected from —NH—, —O—, —S—, or —NR7— where R7 is alkyl of 1-6 carbon atoms R6 is cycloalkyl of 3 to 7 carbon atoms, which may be optionally substituted with one or more alkyl of 1 to 6 carbon atom groups; or is a pyridinyl, pyrimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be substituted with one, two or three specified substitutents; or R6 is a group —R8—X—R9 were R8 is a divalent cycloalkyl of 3 to 7 carbon atoms, which may be optionally further substituted with one or more alkyl of 1 to 6 carbon atom groups; or is an optionally pyridinyl, pyrimidinyl, or phenyl ring; wherein the pyridinyl, pyrimidinyl, or phenyl ring may be optionally further substituted with one or more specified substitutentType: GrantFiled: October 25, 2001Date of Patent: October 28, 2003Assignee: AstraZeneca ABInventor: Keith Hopkinson Gibson
-
Patent number: 5770603Abstract: The invention concerns quinazoline derivatives of the formula I ##STR1## wherein n is 1,2 or 3 and each R.sup.2 is independently halogeno, trifluoromethyl or (1-4C)alkyl;R.sup.1 is (1-4C)alkoxy;A is (1-4C)alkylene; andQ is a saturated, monocyclic 4-, 5-, 6- or 7-membered heterocyclic ring containing one or two oxygen heteroatoms, which ring optionally bears up to four (1-4C)alkyl substituents; or a pharmaceutically-acceptable salt thereof;processes for their preparation, pharmaceutical compositions containing them and the use of their receptor tyrosine kinase inhibitory properties in the treatment of proliferative disease such as cancer.Type: GrantFiled: April 10, 1997Date of Patent: June 23, 1998Assignee: Zeneca LimitedInventor: Keith Hopkinson Gibson
-
Patent number: 5684198Abstract: Amides having formula I: ##STR1## wherein E, X, R.sup.2 and R.sup.3 have the meanings given in the specification, and pharmaceutically acceptable salts and pharmaceutically acceptable in vivo hydrolysable esters thereof,which are useful in the treatment of urinary incontinence. Further provided are processes for preparing the aides and pharmaceutical compositions containing them.Type: GrantFiled: August 23, 1996Date of Patent: November 4, 1997Assignee: Imperial Chemical Industries, PLCInventors: Keith Russell, Cyrus John Ohnmacht, Keith Hopkinson Gibson