Patents by Inventor Keith Knisley
Keith Knisley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11938294Abstract: The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).Type: GrantFiled: January 10, 2022Date of Patent: March 26, 2024Assignee: W. L. Gore & Associates, Inc.Inventors: Edward H. Cully, Edward Gunzel, Keith Knisley, Greg Rusch, Lauren Zambotti
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Patent number: 11504454Abstract: The invention is an improved biocompatible surface for a variety of medical purposes. The biocompatible surface employs a unique tight microstructure that demonstrates enhanced cellular response in the body, particularly when placed in contact with blood. As a blood contact surface, the present invention can be beneficially employed in a wide variety of implantable devices and in many other devices and equipment that come in contact with blood.Type: GrantFiled: May 18, 2015Date of Patent: November 22, 2022Assignee: W. L. Gore & Associates, Inc.Inventors: Keith A. Knisley, Vishnu T. Marla, Rachel Radspinner, Paul A. Silvagni, Jason J. Strid, Michael J. Vonesh
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Publication number: 20220126076Abstract: The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).Type: ApplicationFiled: January 10, 2022Publication date: April 28, 2022Inventors: Edward H. Cully, Edward Gunzel, Keith Knisley, Greg Rusch, Lauren Zambotti
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Publication number: 20210268245Abstract: The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).Type: ApplicationFiled: May 19, 2021Publication date: September 2, 2021Inventors: Edward H. Cully, Edward Gunzel, Keith Knisley, Greg Rusch, Lauren Zambotti
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Patent number: 11052230Abstract: The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).Type: GrantFiled: November 7, 2017Date of Patent: July 6, 2021Assignee: W. L. Gore & Associates, Inc.Inventors: Edward H. Cully, Edward Gunzel, Keith Knisley, Greg Rusch, Lauren Zambotti
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Publication number: 20180126134Abstract: The present disclosure relates to implantable encapsulation devices for housing a biological moiety or a therapeutic device that contains a biological moiety. Particularly, aspects of the present disclosure are directed to an implantable apparatus that includes a distal end, a proximal end, a manifold including at least one access port positioned either at the distal end or the proximal end, and a plurality of containment tubes affixed to the manifold and in fluid communication with the at least one access port. Additionally, the encapsulation device may contain a flush port and a tube that are fluidly connected to the manifold. The containment tubes may contain therein a biological moiety (e.g., cells) or a therapeutic device (e.g. a cell encapsulation member).Type: ApplicationFiled: November 7, 2017Publication date: May 10, 2018Inventors: Edward H. Cully, Edward Gunzel, Keith Knisley, Greg Rusch, Lauren Zambotti
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Patent number: 9775933Abstract: The invention is an improved biocompatible surface for a variety of medical purposes. The biocompatible surface employs a unique tight microstructure that demonstrates enhanced cellular response in the body, particularly when placed in contact with blood. As a blood contact surface, the present invention can be beneficially employed in a wide variety of implantable devices and in many other devices and equipment that come in contact with blood.Type: GrantFiled: February 22, 2013Date of Patent: October 3, 2017Assignee: W. L. Gore & Associates, Inc.Inventors: Keith A. Knisley, Vishnu T. Marla, Rachel Radspinner, Paul A. Silvagni, Jason J. Strid, Michael J. Vonesh
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Publication number: 20150258250Abstract: The invention is an improved biocompatible surface for a variety of medical purposes. The biocompatible surface employs a unique tight microstructure that demonstrates enhanced cellular response in the body, particularly when placed in contact with blood. As a blood contact surface, the present invention can be beneficially employed in a wide variety of implantable devices and in many other devices and equipment that come in contact with blood.Type: ApplicationFiled: May 18, 2015Publication date: September 17, 2015Inventors: Keith A. Knisley, Vishnu T. Marla, Rachel Radspinner, Paul A. Silvagni, Jason J. Strid, Michael J. Vonesh
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Publication number: 20130231733Abstract: The invention is an improved biocompatible surface for a variety of medical purposes. The biocompatible surface employs a unique tight microstructure that demonstrates enhanced cellular response in the body, particularly when placed in contact with blood. As a blood contact surface, the present invention can be beneficially employed in a wide variety of implantable devices and in many other devices and equipment that come in contact with blood.Type: ApplicationFiled: February 22, 2013Publication date: September 5, 2013Applicant: W. L. GORE & ASSOCIATES, INC.Inventors: KEITH A. KNISLEY, VISHNU T. MARLA, RACHEL RADSPINNER, PAUL A. SILVAGNI, JASON J. STRID, MICHAEL J. VONESH
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Patent number: 5173160Abstract: New synthesis and analysis procedures for novel crosslinked polyamines and ampholytes. Polyamines are crosslinked with tartaric acid ester, malonic acid ester, or polycarboxylic acid esters of the citric acid cycle. The resulting crosslinked polyamine may further react with other compounds such as an .alpha., .beta.-unsaturated or .alpha.-halo unsaturated carboxylic acids to prepare new ampholyte mixtures. The resulting novel ampholytes exhibit greater heterogeneity and complexity than presently prepared ampholytes, and can be used in analytical and preparative isoelectric focusing processes.Novel ampholyte analysis process entails analyzing chemical compounds, usually ampholytes, used in isoelectric focusing processes. The ampholyte is isoelectrically focused on an immobilized pH gradient, and then immersed in a picric acid solution to cGOVERNMENT OWNERSHIPThe funding for the subject matter described herein was partially provided by the U.S. Government under Grant Nos. NAS 9-17403 and NIH AI-20590. The U.S.Type: GrantFiled: February 27, 1991Date of Patent: December 22, 1992Assignee: Board of Regents, The University of Texas SystemInventors: L. Scott Rodkey, Keith A. Knisley