Abstract: Embodiments of the disclosed technologies apply a logistic regression model to a set of population data for a set of genes. The set of population data includes a set of features for a variant located at a position within a gene. The set of features includes at least one population frequency meta-feature. The at least one population frequency meta-feature quantifies predictive value of allele frequency in the gene. Using the first set of population data, a variant classification prediction output by the logistic regression model is evaluated based on an expected variant classification. The logistic regression model is adjusted until at least one first performance criterion is satisfied to produce a trained logistic regression model. The trained logistic regression model is capable of outputting variant pathogenicity estimates that satisfy at least one second performance criterion.

Abstract: The disclosure describes an automated system and method to manufacture extruded split tees, spherical tees, and full encirclement saddle (FES) component parts. The system and method provide for the manufacture of pipe reinforcement components from raw material plates, comprising: an input storage for the raw material plates; one or more ovens for heating the plates; one or more extrusion presses for extruding the heated raw material plates into one or more pipe reinforcement components and an output storage for the pipe reinforcement components. A robotic device is adapted to automatically access and perform operations at the input storage, at the one or more ovens, at the one or more extrusion presses, and at the output storage.

Abstract: The disclosure describes an automated system and method to manufacture extruded split tees, spherical tees, and full encirclement saddle (FES) component parts. The system and method provide for the manufacture of pipe reinforcement components from raw material plates, comprising: an input storage for the raw material plates; one or more ovens for heating the plates; one or more extrusion presses for extruding the heated raw material plates into one or more pipe reinforcement components and an output storage for the pipe reinforcement components. A robotic device is adapted to automatically access and perform operations at the input storage, at the one or more ovens, at the one or more extrusion presses, and at the output storage.

Abstract: Embodiments of systems and methods for installing a single valve assembly into in-service pipelines are presented using conventional hot tap technology. In one embodiment, the single valve assembly may comprise a removable cartridge assembly that comprises a wedge assembly that is rotated from an open position to a closed position and movable from a first unexpanded position to a second compressed position that sealingly engages one or more sealing elements to the valve body or housing to prevent fluid flow in the pipeline. The cartridge assembly is configured to be removed from the valve body for repair, maintenance, or replacement without additional line stops or interruptions to the in-service pipeline.

Abstract: Embodiments of systems and methods for installing a single valve assembly into in-service pipelines are presented using conventional hot tap technology. In one embodiment, the single valve assembly may comprise a removable cartridge assembly that comprises a wedge assembly that is rotated from an open position to a closed position and movable from a first unexpanded position to a second compressed position that sealingly engages one or more sealing elements to the valve body or housing to prevent fluid flow in the pipeline. The cartridge assembly is configured to be removed from the valve body for repair, maintenance, or replacement without additional line stops or interruptions to the in-service pipeline.