Patents by Inventor Keith Kretz

Keith Kretz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant bacterial phytases and uses thereof
    Patent number: 7452706
    Abstract: A purified recombinant phytase enzyme derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: November 18, 2008
    Assignee: Verenium Corporation
    Inventors: Jay M. Short, Keith A. Kretz, Dan E. Robertson
  • Phytases, nucleic acids encoding them and methods of making and using them
    Patent number: 7432097
    Abstract: In one aspect, the invention provides a purified and modified phytase enzyme from Escherichia coli K12 appA phytase. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved protease stability at low pH. Glycosylation of the modified phytase provided a further improved enzyme having improved thermal tolerance and protease stability. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In one aspect, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
    Type: Grant
    Filed: September 1, 2004
    Date of Patent: October 7, 2008
    Assignee: Verenium Corporation
    Inventors: Jay M. Short, Keith A. Kretz, Kevin A. Gray, Nelson Robert Barton, James B. Garrett, Eileen O'Donoghue, William Baum, Dan E. Robertson, Paul Zorner
  • Nanoarchaeum genome, Nanoarchaeum polypeptides and nucleic acids encoding them and methods for making and using them
    Publication number: 20080168572
    Abstract: The invention provides a genome of the hyperthermophile Nanoarchaeum equitans, polypeptides, including enzymes, structural protein and binding proteins, derived from this genome, polynucleotides encoding these polypeptides, methods of making and using these polynucleotides and polypeptides. The invention also provides isolated hyperthermophile Nanoarchaeum equitans.
    Type: Application
    Filed: May 1, 2003
    Publication date: July 10, 2008
    Applicant: Diversa Corporation
    Inventors: Karl O. Stetter, Elizabeth Waters, Keith Kretz, Mircea Podar, Toby Richardson, Michiel Noordewier
  • Microbially-expressed thermotolerant phytase for animal feed
    Publication number: 20080131560
    Abstract: The invention provides methods for making and using thermotolerant phytases, e.g., a method of using a thermotolerant phytase in feed and food processing and feed or food products comprising a thermotolerant phytase.
    Type: Application
    Filed: June 15, 2007
    Publication date: June 5, 2008
    Inventors: Michael B. Lanahan, Edward Koepf, Keith Kretz
  • Microbially-expressed thermotolerant phytase for animal feed
    Patent number: 7252983
    Abstract: The invention provides methods for making and using thermotolerant phytases, e.g., a method of using a thermotolerant phytase in feed and food processing and feed or food products comprising a thermotolerant phytase.
    Type: Grant
    Filed: October 17, 2006
    Date of Patent: August 7, 2007
    Assignee: Syngenta Participations AG
    Inventors: Michael B. Lanahan, Edward Koepf, Keith Kretz
  • Phytase expression systems and methods of making and using them
    Patent number: 7232677
    Abstract: The invention provides a purified or recombinant phytase enzyme (SEQ ID NO:2) initially derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity (SEQ ID NO:2). The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
    Type: Grant
    Filed: February 5, 2001
    Date of Patent: June 19, 2007
    Assignee: Diversa Corporation
    Inventors: Jay M. Short, Keith A. Kretz
  • Microbially-expressed thermotolerant phytase for animal feed
    Publication number: 20070087410
    Abstract: The invention provides methods for making and using thermotolerant phytases, e.g., a method of using a thermotolerant phytase in feed and food processing and feed or food products comprising a thermotolerant phytase.
    Type: Application
    Filed: October 17, 2006
    Publication date: April 19, 2007
    Inventors: Michael Lanahan, Edward Koepf, Keith Kretz
  • Microbially-expressed thermotolerant phytase for animal feed
    Patent number: 7138260
    Abstract: The invention provides methods for making and using thermotolerant phytases, e.g., a method of using a thermotolerant phytase in feed and food processing and feed or food products comprising a thermotolerant phytase.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: November 21, 2006
    Assignees: Syngenta Participations AG, Diversa Corporation
    Inventors: Michael B. Lanahan, Edward Koepf, Keith Kretz
  • Microbially expressed thermotolerant phytase for animal feed
    Patent number: 7135323
    Abstract: The invention provides methods for making and using thermotolerant phytases, e.g., a method of using a thermotolerant phytase in feed and food processing and feed or food products comprising a thermotolerant phytase.
    Type: Grant
    Filed: December 30, 2002
    Date of Patent: November 14, 2006
    Assignees: Syngenta Participations AG, Diversa Corporation
    Inventors: Michael L. Lanahan, Edward Koepf, Keith Kretz
  • Microbially-expressed thermotolerant phytase for animal feed
    Publication number: 20060183213
    Abstract: The invention provides methods for making and using thermotolerant phytases, e.g., a method of using a thermotolerant phytase in feed and food processing and feed or food products comprising a thermotolerant phytase.
    Type: Application
    Filed: March 20, 2006
    Publication date: August 17, 2006
    Inventors: Michael Lanahan, Edward Koepf, Keith Kretz
  • Phytases, nucleic acids encoding them and methods of making and using them
    Publication number: 20050281792
    Abstract: In one aspect, the invention provides a purified and modified phytase enzyme from Escherichia coli K12 appA phytase. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved protease stability at low pH. Glycosylation of the modified phytase provided a further improved enzyme having improved thermal tolerance and protease stability. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In one aspect, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
    Type: Application
    Filed: September 1, 2004
    Publication date: December 22, 2005
    Inventors: Jay Short, Keith Kretz, Kevin Gray, Nelson Barton, James Garrett, Eileen O'Donoghue, William Baum, Dan Robertson, Paul Zorner
  • Phytases, nucleic acids encoding them and methods for making and using them
    Publication number: 20050246780
    Abstract: The invention provides isolated and recombinant phytase enzymes. In one aspect, the phytases are produced by modification of the wild type appA of E. coli. The enzyme can be produced from recombinant host cells. The phytases of the invention can be used to aid in the digestion of phytate where desired. In particular, the phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be thermotolerant and/or thermostable. Also provided are methods for obtaining a variant polynucleotide encoding a phytase and for obtaining a phytase with thermostability or thermotolerant at high or low temperatures.
    Type: Application
    Filed: February 11, 2005
    Publication date: November 3, 2005
    Inventors: Jay Short, Keith Kretz, Kevin Gray, Nelson Barton, James Garrett, Eileen O'Donoghue, Eric Mathur
  • Recombinant bacterial phytases and uses thereof
    Patent number: 6855365
    Abstract: A purified and modified phytase enzyme from Escherichia coli K12 appA phytase is provided. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved protease stability at low pH. Glycosylation of the modified phytase provided a further improved enzyme having improved thermal tolerance and protease stability. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
    Type: Grant
    Filed: May 24, 2001
    Date of Patent: February 15, 2005
    Assignee: Diversa Corporation
    Inventors: Jay M. Short, Keith A. Kretz, Kevin A. Gray, Nelson Robert Barton, James B. Garrett, Eileen O'Donoghue, Eric J. Mathur
  • Recombinant phytases and methods of making and using them
    Publication number: 20040091968
    Abstract: A purified and modified phytase enzyme from Escherichia coli K12 appA phytase is provided. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved protease stability at low pH. Glycosylation of the modified phytase provided a further improved enzyme having improved thermal tolerance and protease stability. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
    Type: Application
    Filed: June 20, 2003
    Publication date: May 13, 2004
    Inventors: Jay M. Short, Keith Kretz, Kevin A. Gray, Nelson R. Barton, James B. Garrett, Eileen O'Donoghue, Eric J. Mather
  • Phytase-containing foodstuffs and methods of making and using them
    Patent number: 6720014
    Abstract: A purified recombinant phytase enzyme derived from Escherichia coli B. The enzyme has a molecular light of about 47.1 kilodaltons and has phytase activity. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
    Type: Grant
    Filed: May 25, 2000
    Date of Patent: April 13, 2004
    Assignee: Diversa Corporation
    Inventors: Jay M. Short, Keith A. Kretz
  • Recombinant bacterial phytases and uses thereof
    Publication number: 20030232041
    Abstract: A purified recombinant phytase enzyme derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
    Type: Application
    Filed: May 5, 2003
    Publication date: December 18, 2003
    Inventors: Jay M. Short, Keith Kretz
  • Microbially expressed thermotolerant phytase for animal feed
    Publication number: 20030157646
    Abstract: The invention provides methods for making and using thermotolerant phytases, e.g., a method of using a thermotolerant phytase in feed and food processing and feed or food products comprising a thermotolerant phytase.
    Type: Application
    Filed: December 30, 2002
    Publication date: August 21, 2003
    Applicant: Syngenta Participations AG
    Inventors: Michael B. Lanahan, Edward Koepf, Keith A. Kretz
  • Phytases, nucleic acids encoding them and methods for making and using them
    Publication number: 20030103958
    Abstract: The invention provides isolated and recombinant phytase enzymes. In one aspect, the phytases are produced by modification of the wild type appA of E. coli. The enzyme can be produced from recombinant host cells. The phytases of the invention can be used to aid in the digestion of phytate where desired. In particular, the phytases of the invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients. The phytases of the invention can be thermotolerant and/or thermostable. Also provided are methods for obtaining a variant polynucleotide encoding a phytase and for obtaining a phytase with thermostability or thermotolerant at high or low temperatures.
    Type: Application
    Filed: May 24, 2002
    Publication date: June 5, 2003
    Applicant: Diversa Corporation
    Inventors: Jay M. Short, Keith Kretz, Kevin A. Gray, Nelson R. Barton, James B. Garrett, Eileen O'Donoghue, Eric J. Mathur
  • Recombinant bacterial phytases and uses thereof
    Publication number: 20020136754
    Abstract: A purified and modified phytase enzyme from Escherichia coli K12 appA phytase is provided. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved protease stability at low pH. Glycosylation of the modified phytase provided a further improved enzyme having improved thermal tolerance and protease stability. The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
    Type: Application
    Filed: May 24, 2001
    Publication date: September 26, 2002
    Inventors: Jay M. Short, Keith A. Kretz, Kevin A. Gray, Nelson Robert Barton, James B. Garrett, Eileen O' Donoghue, Eric J. Mathur
  • Recombinant bacterial phytases and uses thereof
    Publication number: 20010055788
    Abstract: A purified recombinant phytase enzyme derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity (SEQ ID NO:2). The enzyme can be produced from native or recombinant host cells and can be used to aid in the digestion of phytate where desired. In particular, the phytase of the present invention can be used in foodstuffs to improve the feeding value of phytate rich ingredients.
    Type: Application
    Filed: February 5, 2001
    Publication date: December 27, 2001
    Applicant: Diversa Corporation
    Inventors: Jay M. Short, Keith A. Kretz