Patents by Inventor Keith L. Knutson

Keith L. Knutson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Breast Cancer Vaccine
    Publication number: 20230233656
    Abstract: The invention relates to vaccines for breast cancer therapy. The invention also relates to methods of preventing and treating breast cancer using a breast cancer vaccine.
    Type: Application
    Filed: June 25, 2021
    Publication date: July 27, 2023
    Applicant: National Breast Cancer Coalition
    Inventor: Keith L. Knutson
  • Immunity to folate receptors
    Patent number: 10948480
    Abstract: This document provides methods and materials related to assessing immunity to folate receptors. For example, methods and materials for assessing FR? immunity in a mammal are provided. This document also provides methods and materials related to stimulating immunity to folate receptors.
    Type: Grant
    Filed: March 12, 2018
    Date of Patent: March 16, 2021
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Keith L. Knutson, Lynn C. Hartmann, Kimberly R. Kalli, Christopher J. Krco
  • HLA-DR binding peptides and their uses
    Patent number: 10556943
    Abstract: The present invention provides HLA-DR (MHC class II) binding peptides derived from the ovarian/breast cancer associated antigens, Human Epidermal Growth Factor Receptor 2 (HER-2/neu), Carcinoembryonic Antigen (CEA), Insulin Growth Factor Binding Protein 2 (IGFBP-2), and Cyclin D1. The immunogenic peptides can be used in cancer vaccines.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: February 11, 2020
    Assignees: Mayo Foundation for Medical Education and Research, University of Washington
    Inventors: Keith L. Knutson, Mary L. Disis, John D. Fikes, Melanie Beebe, Glenn Ishioka
  • METHODS AND MATERIALS FOR GENERATING T CELLS
    Publication number: 20180355015
    Abstract: The document provides to methods and materials for generating T cells (e.g., antigen-specific CD4+ T cells). For example, methods and materials for using nested MHC class II epitopes as vaccines to generate activated CD4+ T cells in vivo or as reagents to generate activated CD4+ T cells ex vivo are provided.
    Type: Application
    Filed: June 20, 2018
    Publication date: December 13, 2018
    Inventor: Keith L. Knutson
  • Methods and materials for generating CD8T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide
    Patent number: 10117919
    Abstract: This document provides methods and materials for generating CD8? T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide. For example, methods and materials for using a polypeptide consisting of an SLAFLPESFD amino acid sequence in vivo or in vitro to generate CD8+ T cells having the ability to recognize and lyse cancer cells expressing a HER2/neu polypeptide are provided.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: November 6, 2018
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Keith L. Knutson, Andrea M. Henle
  • IMMUNITY TO FOLATE RECEPTORS
    Publication number: 20180231521
    Abstract: This document provides methods and materials related to assessing immunity to folate receptors. For example, methods and materials for assessing FR? immunity in a mammal are provided. This document also provides methods and materials related to stimulating immunity to folate receptors.
    Type: Application
    Filed: March 12, 2018
    Publication date: August 16, 2018
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Keith L. Knutson, Lynn C. Hartmann, Kimberly R. Kalli, Christopher J. Krco
  • Immunity to folate receptors
    Patent number: 9915646
    Abstract: This document provides methods and materials related to assessing immunity to folate receptors. For example, methods and materials for assessing FR? immunity in a mammal are provided. This document also provides methods and materials related to stimulating immunity to folate receptors.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: March 13, 2018
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Keith L. Knutson, Lynn C. Hartmann, Kimberly R. Kalli, Christopher J. Krco
  • METHODS AND MATERIALS FOR GENERATING CD8+ T CELLS HAVING THE ABILITY TO RECOGNIZE CANCER CELLS EXPRESSING A HER2/NEU POLYPEPTIDE
    Publication number: 20180064797
    Abstract: This document provides methods and materials for generating CD8? T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide. For example, methods and materials for using a polypeptide consisting of an SLAFLPESFD amino acid sequence in vivo or in vitro to generate CD8+ T cells having the ability to recognize and lyse cancer cells expressing a HER2/neu polypeptide are provided.
    Type: Application
    Filed: November 13, 2017
    Publication date: March 8, 2018
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Keith L. Knutson, Andrea M. Henle
  • HLA-DR BINDING PEPTIDES AND THEIR USES
    Publication number: 20170342126
    Abstract: The present invention provides HLA-DR (MHC class II) binding peptides derived from the ovarian/breast cancer associated antigens, Human Epidermal Growth Factor Receptor 2 (HER-2/neu), Carcinoembryonic Antigen (CEA), Insulin Growth Factor Binding Protein 2 (IGFBP-2), and Cyclin D1. The immunogenic peptides can be used in cancer vaccines.
    Type: Application
    Filed: December 16, 2016
    Publication date: November 30, 2017
    Inventors: Keith L. Knutson, Mary L. Disis, John D. Fikes, Melanie Beebe, Glenn Ishioka
  • Methods and materials for generating CD8+ T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide
    Patent number: 9814767
    Abstract: This document provides methods and materials for generating CD8+ T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide. For example, methods and materials for using a polypeptide consisting of an SLAFLPESFD amino acid sequence in vivo or in vitro to generate CD8+ T cells having the ability to recognize and lyse cancer cells expressing a HER2/neu polypeptide are provided.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: November 14, 2017
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Keith L. Knutson, Andrea M. Henle
  • Detecting latent tuberculosis infections
    Patent number: 9678071
    Abstract: This document provides methods and materials related to identifying mammals having a LTBI. For example, methods and materials for using ELISpot assays to identify mammals (e.g., humans) having a LTBI are provided.
    Type: Grant
    Filed: January 8, 2013
    Date of Patent: June 13, 2017
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Patricio Escalante, Keith L. Knutson, Tobias Peikert
  • IMMUNITY TO FOLATE RECEPTORS
    Publication number: 20160131638
    Abstract: This document provides methods and materials related to assessing immunity to folate receptors. For example, methods and materials for assessing FR? immunity in a mammal are provided. This document also provides methods and materials related to stimulating immunity to folate receptors.
    Type: Application
    Filed: December 15, 2015
    Publication date: May 12, 2016
    Inventors: Keith L. Knutson, Lynn C. Hartmann, Kimberly R. Kalli, Christopher J. Krco
  • Immunity to folate receptors
    Patent number: 9243033
    Abstract: This document provides methods and materials related to assessing immunity to folate receptors. For example, methods and materials for assessing FR? immunity in a mammal are provided. This document also provides methods and materials related to stimulating immunity to folate receptors.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: January 26, 2016
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Keith L. Knutson, Lynn C. Hartmann, Kimberly R. Kalli, Christopher J. Krco
  • METHODS AND MATERIALS FOR GENERATING CD8+ T CELLS HAVING THE ABILITY TO RECOGNIZE CANCER CELLS EXPRESSING A HER2/NEU POLYPEPTIDE
    Publication number: 20150231218
    Abstract: This document provides methods and materials for generating CD8+ T cells having the ability to recognize cancer cells expressing a HER2/neu polypeptide. For example, methods and materials for using a polypeptide consisting of an SLAFLPESFD amino acid sequence in vivo or in vitro to generate CD8+ T cells having the ability to recognize and lyse cancer cells expressing a HER2/neu polypeptide are provided.
    Type: Application
    Filed: February 15, 2013
    Publication date: August 20, 2015
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Keith L. Knutson, Andrea M. Henle
  • METHODS AND MATERIALS FOR GENERATING T CELLS
    Publication number: 20150056228
    Abstract: The document provides to methods and materials for generating T cells (e.g., antigen-specific CD4+ T cells). For example, methods and materials for using nested MHC class II epitopes as vaccines to generate activated CD4+ T cells in vivo or as reagents to generate activated CD4+ T cells ex vivo are provided.
    Type: Application
    Filed: September 11, 2014
    Publication date: February 26, 2015
    Inventor: Keith L. Knutson
  • DETECTING LATENT TUBERCULOSIS INFECTIONS
    Publication number: 20150010927
    Abstract: This document provides methods and materials related to identifying mammals having a LTBI. For example, methods and materials for using ELISpot assays to identify mammals (e.g., humans) having a LTBI are provided.
    Type: Application
    Filed: January 8, 2013
    Publication date: January 8, 2015
    Applicant: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
    Inventors: Patricio Escalante, Keith L. Knutson, Tobias Peikert
  • HLA-DR BINDING PEPTIDES AND THEIR USES
    Publication number: 20140377340
    Abstract: The present invention provides HLA-DR (MHC class II) binding peptides derived from the ovarian/breast cancer associated antigens, Human Epidermal Growth Factor Receptor 2 (HER-2/neu), Carcinoembryonic Antigen (CEA), Insulin Growth Factor Binding Protein 2 (IGFBP-2), and Cyclin D1. The immunogenic peptides can be used in cancer vaccines.
    Type: Application
    Filed: September 8, 2014
    Publication date: December 25, 2014
    Inventors: Keith L. Knutson, Mary L. Disis, John D. Fikes, Melanie Beebe, Glenn Ishioka
  • Methods and materials for generating T cells
    Patent number: 8858952
    Abstract: The document provides to methods and materials for generating T cells (e.g., antigen-specific CD4+ T cells). For example, methods and materials for using nested MHC class II epitopes as vaccines to generate activated CD4+ T cells in vivo or as reagents to generate activated CD4+ T cells ex vivo are provided.
    Type: Grant
    Filed: February 19, 2010
    Date of Patent: October 14, 2014
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Keith L. Knutson
  • IMMUNITY TO FOLATE RECEPTORS
    Publication number: 20140212443
    Abstract: This document provides methods and materials related to assessing immunity to folate receptors. For example, methods and materials for assessing FR? immunity in a mammal are provided. This document also provides methods and materials related to stimulating immunity to folate receptors.
    Type: Application
    Filed: June 13, 2013
    Publication date: July 31, 2014
    Applicant: Mayo Foundation for Medical Education and Research
    Inventors: Keith L. Knutson, Lynn C. Hartmann, Kimberly R. Kalli, Christopher J. Krco
  • Immunity to folate receptors
    Patent number: 8486412
    Abstract: This document provides methods and materials related to assessing immunity to folate receptors. For example, methods and materials for assessing FR? immunity in a mammal are provided. This document also provides methods and materials related to stimulating immunity to folate receptors.
    Type: Grant
    Filed: June 1, 2007
    Date of Patent: July 16, 2013
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Keith L. Knutson, Lynn C. Hartmann, Kimberly R. Kalli, Christopher J. Krco