Abstract: The invention relates to methods of treating cell proliferative disorders. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer.

Abstract: Provided are compositions and methods of treating cell proliferative disorders, especially cancer. Also provided are methods for assessing and monitoring cell proliferative processes and processes for amelioration of cell proliferative disorders, especially cancer.

Abstract: The invention relates to methods of treating cell proliferative disorders. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer.

Abstract: A spark ignition rotary valve internal combustion engine includes a combustion chamber being defined in part by the piston and the combustion end of the cylinder, a valve housing fixed at an outer portion of the combustion end of the cylinder and defining a bore, and a rotary valve rotatable about a rotary valve axis in the bore in the valve housing. The rotary valve has a hollow valve body subjected to combustion gases throughout the combustion process. The rotary valve also has, in a wall part thereof, a port giving, during rotation of the valve, fluid communication successively to and from the combustion chamber via inlet and exhaust ports in the valve housing. The inlet and exhaust ports are angularly offset with respect to a radial line from the center of the engine cylinder.

Abstract: A rotary valve internal combustion engine has a piston connected to a crankshaft, where the piston is reciprocatable in a cylinder, and a combustion chamber being defined in part by the piston. The engine has a rotary valve rotatable in a valve housing fixed relative to the cylinder, the rotary valve having a valve body containing a volume defining, in part, the combustion chamber and further having in a wall part thereof a port giving, during rotation of the valve, fluid communication successively to and from the combustion chamber via inlet and exhaust ports in the valve housing. The valve body has a non-uniform radial profile along its axial length and/or about its axis of rotation to accommodate changes in the profile of the valve body during operation to maintain a substantially constant clearance between the valve body and the housing throughout the length of the valve body.

Abstract: The invention relates to methods of treating cell proliferative disorders. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer.

Abstract: The invention relates to methods of treating cell proliferative disorders. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer.

Abstract: The invention relates to methods of treating cell proliferative disorders. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer.

Abstract: A rotary valve internal combustion engine has a piston (1) connected to a crankshaft (3) and reciprocatable in a cylinder (2), a combustion chamber 4 being defined in part by the piston. The engine has a rotary valve (5) rotatable with a close sliding fit in a valve housing (8) fixed relative to the cylinder (2), the rotary valve having a valve body containing a volume (9) defining, in part, the combustion chamber 4 and further having in a wall part (11) thereof a port (1)2 giving, during rotation of the valve, fluid communication successively to and from the combustion chamber via inlet and exhaust ports (13), (14) in the valve housing. The rotary valve and the valve housing are both formed of aluminum.

Abstract: Example methods and apparatus to manage testing of a process control system are disclosed. A disclosed example method includes generating a test application from a process control routine, the test application including at least one test that is to be performed within a time period, monitoring an operation of the process control routine, determining if the operation of the process control routine during the time period includes an execution of a portion of the process control routine that is substantially similar to the at least one test, and updating the test application by indicating that the at least one test has been performed within the time period.

Abstract: The invention relates to methods of treating cell proliferative disorders. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer.

Abstract: An example apparatus includes a terminal block couplable to an electronics cabinet or mounting rail. The terminal block defines a first receptacle to receive a first circuit and a second receptacle to receive a second circuit. The terminal block includes an integral relay. The integral relay includes a first contact and a second contact. The first and second contacts are externally accessible relative to the terminal block. The integral relay further includes a first switch and a second switch. The first and second switches are electrically coupled between the first and second contacts. The first and second switches are respectively movable between corresponding open and closed positions. The first and second switches are independently testable to verify the respective operability of the first switch and the second switch.

Abstract: A rotary valve internal combustion engine has a piston connected to a crankshaft and reciprocatable in a cylinder, a combustion chamber being defined in part by the piston. The engine has a rotary valve rotatable in a valve housing fixed relative to the cylinder, the rotary valve having a valve body containing a volume defining, in part, the combustion chamber and further having a wall part thereof a port giving, during rotation of the valve, fluid communication successively to and from the combustion chamber via inlet and exhaust ports in the valve housing, wherein the rotary valve is rotatable about an axis parallel to the axis of rotation of the crankshaft, the valve being mounted in a bearing arrangement which restrains the valve from movement in the axial direction but permits movement in the radial direction.

Abstract: Example apparatus and methods to remove power from a field device are disclosed. An example apparatus includes a first switch to control power to the field device, and a second switch comprising a first gate and a second gate. The second gate is electrically coupled in parallel to the first gate, and the second switch is electrically coupled in series to the first switch. The example apparatus also includes a first diagnostics controller to control the first and second gates, a first processor to control the first switch, a third switch to control power to the field device, and a fourth switch comprising a third gate and a fourth gate. The fourth gate is electrically coupled in parallel to the third gate, and the fourth switch is electrically coupled in series to the third switch. The example apparatus also includes a second processor to control the third switch, and a second diagnostics controller to control the third and fourth gates.

Abstract: The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as methods of modulating cellular proliferation processes, and methods of treating disease, disorders, and symptoms thereof.

Abstract: A disclosed example apparatus includes a termination panel, a shared bus on the termination panel, and a plurality of bases on the termination panel along the shared bus. Each of the bases is to removably receive modules that are to communicate with field devices. Each of the bases includes first and second physical interfaces. The first physical interface is to be communicatively coupled to different types of the field devices and to exchange communications with one or more of the field devices via a plurality of different communication protocols. The second physical interface is to communicatively couple the removably receivable modules to the shared bus to communicate with a controller via the shared bus.

Abstract: Methods and apparatus to detect root causes of alarm patterns in process control systems are disclosed. An example method includes retrieving process control data generated in a process control system during a historical period of time. The process control data includes alarm data associated with alarms activated during the historical period of time. The example method also includes generating an alarm activation timeline for the historical period of time. The alarm activation timeline includes icons representative of the alarms to visually represent a temporal relationship of activation of the alarms, where one of the icons is representative of an alarm that is no longer active. The example method further includes storing the alarm activation timeline in a database.

Abstract: A disclosed example apparatus includes a first interface to be communicatively coupled to one of a first field device or a second field device. The first interface communicates using a first fieldbus communication protocol when coupled to the first field device and communicates using a second fieldbus communication protocol when coupled to the second field device. The example apparatus includes a communication processor to encode first information received from the one of the first field device or the second field device for communication via a bus using a third communication protocol. The example apparatus includes a second interface communicatively coupled to the communication processor and the bus to communicate the first information to a controller in the process control system. The bus is to use the third communication protocol to communicate second information received from the other one of the first field device or the second field device.

Abstract: Example methods and apparatus to configure a process control system using an electronic description language (EDL) script are disclosed. A disclosed example method comprises loading a first script representative of a process plant, the first script comprising an interpretive system-level script structured in accordance with an electronic description language, and compiling the first script to form a second script, the second script structured in accordance with a vendor-specific configuration language associated with a particular process control system for the process plant.

Abstract: Methods and apparatus to apply multiple trip limits to a device in a process control system are disclosed. An example method involves monitoring a value of a parameter associated with the operation of the device and receiving an input indicative of an operational state of the device, where a first input indicates a first operational state and a second input indicates a second operational state. If the first input is received, comparing via a function block the value of the parameter to a first trip limit, and if the second input is received, comparing via the function block the value of the parameter to a second trip limit, and implementing a response based on the comparison.