Abstract: Provided are compositions and methods of treating cell proliferative disorders, especially cancer. Also provided are methods for assessing and monitoring cell proliferative processes and processes for amelioration of cell proliferative disorders, especially cancer.

Abstract: The invention relates to methods of treating cell proliferative disorders. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer.

Abstract: The invention relates to methods of treating cell proliferative disorders. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer.

Abstract: The invention relates to methods of treating cell proliferative disorders. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer.

Abstract: The invention relates to methods of treating cell proliferative disorders. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer.

Abstract: Example methods and apparatus to manage testing of a process control system are disclosed. A disclosed example method includes generating a test application from a process control routine, the test application including at least one test that is to be performed within a time period, monitoring an operation of the process control routine, determining if the operation of the process control routine during the time period includes an execution of a portion of the process control routine that is substantially similar to the at least one test, and updating the test application by indicating that the at least one test has been performed within the time period.

Abstract: The invention relates to methods of treating cell proliferative disorders. The invention further relates to pharmaceutical compositions for treating cell proliferative disorders, especially cancer.

Abstract: An example apparatus includes a terminal block couplable to an electronics cabinet or mounting rail. The terminal block defines a first receptacle to receive a first circuit and a second receptacle to receive a second circuit. The terminal block includes an integral relay. The integral relay includes a first contact and a second contact. The first and second contacts are externally accessible relative to the terminal block. The integral relay further includes a first switch and a second switch. The first and second switches are electrically coupled between the first and second contacts. The first and second switches are respectively movable between corresponding open and closed positions. The first and second switches are independently testable to verify the respective operability of the first switch and the second switch.

Abstract: Example apparatus and methods to remove power from a field device are disclosed. An example apparatus includes a first switch to control power to the field device, and a second switch comprising a first gate and a second gate. The second gate is electrically coupled in parallel to the first gate, and the second switch is electrically coupled in series to the first switch. The example apparatus also includes a first diagnostics controller to control the first and second gates, a first processor to control the first switch, a third switch to control power to the field device, and a fourth switch comprising a third gate and a fourth gate. The fourth gate is electrically coupled in parallel to the third gate, and the fourth switch is electrically coupled in series to the third switch. The example apparatus also includes a second processor to control the third switch, and a second diagnostics controller to control the third and fourth gates.

Abstract: The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as methods of modulating cellular proliferation processes, and methods of treating disease, disorders, and symptoms thereof.

Abstract: A disclosed example apparatus includes a termination panel, a shared bus on the termination panel, and a plurality of bases on the termination panel along the shared bus. Each of the bases is to removably receive modules that are to communicate with field devices. Each of the bases includes first and second physical interfaces. The first physical interface is to be communicatively coupled to different types of the field devices and to exchange communications with one or more of the field devices via a plurality of different communication protocols. The second physical interface is to communicatively couple the removably receivable modules to the shared bus to communicate with a controller via the shared bus.

Abstract: Methods and apparatus to detect root causes of alarm patterns in process control systems are disclosed. An example method includes retrieving process control data generated in a process control system during a historical period of time. The process control data includes alarm data associated with alarms activated during the historical period of time. The example method also includes generating an alarm activation timeline for the historical period of time. The alarm activation timeline includes icons representative of the alarms to visually represent a temporal relationship of activation of the alarms, where one of the icons is representative of an alarm that is no longer active. The example method further includes storing the alarm activation timeline in a database.

Abstract: A disclosed example apparatus includes a first interface to be communicatively coupled to one of a first field device or a second field device. The first interface communicates using a first fieldbus communication protocol when coupled to the first field device and communicates using a second fieldbus communication protocol when coupled to the second field device. The example apparatus includes a communication processor to encode first information received from the one of the first field device or the second field device for communication via a bus using a third communication protocol. The example apparatus includes a second interface communicatively coupled to the communication processor and the bus to communicate the first information to a controller in the process control system. The bus is to use the third communication protocol to communicate second information received from the other one of the first field device or the second field device.

Abstract: Example methods and apparatus to configure a process control system using an electronic description language (EDL) script are disclosed. A disclosed example method comprises loading a first script representative of a process plant, the first script comprising an interpretive system-level script structured in accordance with an electronic description language, and compiling the first script to form a second script, the second script structured in accordance with a vendor-specific configuration language associated with a particular process control system for the process plant.

Abstract: Methods and apparatus to apply multiple trip limits to a device in a process control system are disclosed. An example method involves monitoring a value of a parameter associated with the operation of the device and receiving an input indicative of an operational state of the device, where a first input indicates a first operational state and a second input indicates a second operational state. If the first input is received, comparing via a function block the value of the parameter to a first trip limit, and if the second input is received, comparing via the function block the value of the parameter to a second trip limit, and implementing a response based on the comparison.

Abstract: A Unified Threat Management System (UTMS) for securing network traffic in a process control system may comprise network devices configured to receive network traffic related to the process control system and including a ruleset received from an external source. The ruleset may include one or more rules defining a condition to accept or deny the network traffic received at the network device. The state of the network device may be integrated into the process control system as a process control object or variable, thus allowing the state and other UTMS and component network device parameters and variables to be displayed to an operator at a workstation within a graphical process control system environment. The network devices may also communicate with a perpetual service that proactively supplies the devices with rulesets to meet the latest security threats, threat patterns, and control system vulnerabilities found or predicted to exist within the network.

Abstract: Methods, apparatus, and articles of manufacture to provide firewalls for process control systems are disclosed. An example method includes analyzing a network communication to identify a first service, an address associated with the first service within a secured portion of a network, and a subset of ports used by the first service, the network communication originating from within the secured portion of the network and to be transmitted to a destination outside of the secured portion of the network, and storing an identifier of the first service, the address, and the subset of the ports when the network communication includes the identifier, the address, and the subset of the ports.

Abstract: Example apparatus and methods to communicatively couple field devices to controllers in a process control system are disclosed. An example method of changing a communication protocol of a first field device in a process control system includes decoupling from the first field device a first removable communication module configured to communicate using a first communication protocol. The example method also includes coupling to the first field device a second removable communication module configured to communicate using a second communication protocol. After coupling the second removable communication module, the first field device is configured to communicate using the second communication protocol.

Abstract: A disclosed example apparatus includes a first interface to be communicatively coupled to one of a first field device or a second field device. The first interface communicates using a first fieldbus communication protocol when coupled to the first field device and communicates using a second fieldbus communication protocol when coupled to the second field device. The example apparatus includes a communication processor to encode first information received from the one of the first field device or the second field device for communication via a bus using a third communication protocol. The example apparatus includes a second interface communicatively coupled to the communication processor and the bus to communicate the first information to a controller in the process control system. The bus is to use the third communication protocol to communicate second information received from the other one of the first field device or the second field device.

Abstract: Example removable security modules for use with process control devices and related methods are disclosed. An example removable security module includes a body configured to be removably coupled to the process control device and a memory disposed in the body with a shared secret stored in the memory. The example removable security module also includes a processing unit disposed in the body, coupled to the memory and configured to read information from the process control device, compare the information to the shared secret and authenticate the process control device based on the comparison.