Patents by Inventor Keith M. Maclin

Keith M. Maclin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphonic acid derivatives
    Patent number: 6054444
    Abstract: The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.
    Type: Grant
    Filed: April 24, 1997
    Date of Patent: April 25, 2000
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Keith M. Maclin, Kevin L. Tays, Barbara S. Slusher
  • NAALADase inhibitors
    Patent number: 6046180
    Abstract: The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
    Type: Grant
    Filed: May 27, 1997
    Date of Patent: April 4, 2000
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Barbara S. Slusher, Kevin L. Tays, Keith M. Maclin
  • Inhibitors of NAALADase enzyme activity
    Patent number: 6025345
    Abstract: The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
    Type: Grant
    Filed: July 25, 1997
    Date of Patent: February 15, 2000
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Barbara S. Slusher, Kevin L. Tays, Keith M. Maclin
  • Certain dioic acid derivatives useful as NAALADase inhibitors
    Patent number: 6025344
    Abstract: The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
    Type: Grant
    Filed: May 27, 1997
    Date of Patent: February 15, 2000
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Barbara S. Slusher, Kevin L. Tays, Keith M. Maclin
  • Pharmaceutical compositions and methods of treating a glutamate abnormality and effecting a neuronal activity in an animal using NAALADase inhibitors
    Patent number: 6017903
    Abstract: The present invention relates to a method of treating a glutamate abnormality and a method of effecting a neuronal activity in an animal using a NAALADase inhibitor, and a pharmaceutical composition comprising an effective amount of a NAALADase inhibitor for treating a glutamate abnormality and effecting a neuronal activity in an animal.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: January 25, 2000
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Barbara S. Slusher, Paul F. Jackson, Kevin L. Tays, Keith M. Maclin
  • Methods of cancer treatment using naaladase inhibitors
    Patent number: 6011021
    Abstract: The present disclosure relates to dipeptidase inhibitors, and more particularly, to novel methods of using phosphonate derivatives, hydroxyphosphinyl derivatives, and phosphoramidate derivatives to inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, and to treat prostate diseases, especially using the compounds of the present invention for the inhibition of the growth of prostate cancer cells.
    Type: Grant
    Filed: May 28, 1997
    Date of Patent: January 4, 2000
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Barbara S. Slusher, Paul F. Jackson, Kevin L. Tays, Keith M. Maclin
  • Pharmaceutical compositions and methods of treating compulsive disorders using NAALADase inhibitors
    Patent number: 5977090
    Abstract: The present invention relates to a pharmaceutical composition and a method for treating a compulsive disorder using a NAALADase inhibitor.
    Type: Grant
    Filed: July 23, 1997
    Date of Patent: November 2, 1999
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Barbara S. Slusher, Paul F. Jackson, Kevin L. Tays, Keith M. Maclin
  • Hydroxamic acid derivatives
    Patent number: 5962521
    Abstract: The present invention relates to hydroxamic acid derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: October 5, 1999
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Kevin L. Tays, Keith M. Maclin, Barbara S. Slusher
  • Certain sulfoxide and sulfone derivatives
    Patent number: 5902817
    Abstract: The present invention relates to thio derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.
    Type: Grant
    Filed: April 9, 1997
    Date of Patent: May 11, 1999
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Kevin L. Tays, Keith M. Maclin, Barbara S. Slusher
  • Phosphoramidate derivatives
    Patent number: 5863536
    Abstract: The present invention includes phosphoramidate derivatives, compositions containing the same, and methods of using them as NAALADase inhibitors, particularly for the treatment of glutamate abnormalities and associated nervous tissue insult in a animal and for treatment of prostate disease and prostate cancer by inhibition of NAALADase enzyme.
    Type: Grant
    Filed: December 31, 1996
    Date of Patent: January 26, 1999
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Barbara S. Slusher, Kevin L. Tays, Keith M. Maclin
  • Inhibitors of NAALADase enzyme activity
    Patent number: 5795877
    Abstract: The present invention includes compounds, compositions, and methods of treatment for glutamate abnormalities and associated nervous tissue insult in a animal by inhibition of NAALADase enzyme. Compositions include phosphonate derivatives and mixtures thereof that inhibit NAALADase enzyme activity and their use for treating glutamate abnormalities such as created by global and focal ischemia and for treatment of prostate disease and prostate cancer by inhibition of NAALADase enzyme.
    Type: Grant
    Filed: December 31, 1996
    Date of Patent: August 18, 1998
    Assignee: Guilford Pharmaceuticals Inc.
    Inventors: Paul F. Jackson, Barbara S. Slusher, Kevin L. Tays, Keith M. Maclin