Patents by Inventor Keith M. Witherup

Keith M. Witherup has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thrombin inhibitors
    Patent number: 5798377
    Abstract: A compound which inhibits human thrombin and where has the structure ##STR1## such as ##STR2##
    Type: Grant
    Filed: October 21, 1996
    Date of Patent: August 25, 1998
    Assignee: Merck & Co., Inc.
    Inventors: William C. Lumma, Thomas J. Tucker, Keith M. Witherup, Stephen F. Brady, Willie L. Whitter, Joseph P. Vacca, Craig Coburn, Jules A. Shafer
  • Pyrroloquinoline Bradykinin antagonist
    Patent number: 5288725
    Abstract: A pyrroloquinoline compound of the following formula is disclosed: ##STR1## wherein H,C.sub.1-6 alkyl,R.sup.1 is: ##STR2## wherein R is H, C.sub.1-10 alkyl, or C.sub.1-6 alkyloxycarbonyl; R.sup.2 is:H,C.sub.1-6 alkyl, ##STR3## wherein R.sup.5 is C.sub.1-10 alkyl, aryl, or aryl C.sub.1-10 alkyl; R.sup.3 is:(CH.sub.2).sub.n NHR wherein R is H, C.sub.1-6 alkyl, or C.sub.1-6 alkyloxycarbonyl; ##STR4## R.sup.4 is: H,C.sub.1-6 alkyl,C.sub.1-6 alkyloxycarbonyl,RCH.sub.2 --, wherein R is H, C.sub.1-6 alkyl or aryl, or ##STR5## X is O, or NR.sup.6 wherein R.sup.6 is equal to H or C.sub.1-6 alkyl and n is an integer from 1-3.The compounds of the invention exhibit bradykinin antagonist activity as well as activity with .alpha.-adrenergic, histaminergic, and muscarinic receptors.
    Type: Grant
    Filed: October 15, 1992
    Date of Patent: February 22, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Keith M. Witherup, Richard W. Ransom, Sandor L. Varga, Steven M. Pitzenberger, Victor J. Lotti, William J. Lumma