Patents by Inventor Keith March
Keith March has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190117702Abstract: Disclosed herein is that the systemic administration of ASC conditioned media diminished LPS-induced lung injury by inhibiting epithelial permeability, neutrophil inflammatory response, and secretion of pro-inflammatory TNF?. It is also shown that ARDS lung is able to retain IV-delivered ASC for a substantial amount of time, with no evidence of the significant cell distribution to other organs at this time point. These findings provide optimization of cell-based and cell-free therapy for the treatment of ARDS, including occurrences of ARDS caused by upper respiratory tract infections such as SARS and MERS.Type: ApplicationFiled: October 31, 2018Publication date: April 25, 2019Applicants: Indiana University Research and Technology Corporation, The United States of America as represented by the Department of Veterans AffairsInventors: Keith March, Natalia Bogatcheva
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Patent number: 10143709Abstract: Disclosed herein is that the systemic administration of ASC conditioned media diminished LPS-induced lung injury by inhibiting epithelial permeability, neutrophil inflammatory response, and secretion of pro-inflammatory TNF?. It is also shown that ARDS lung is able to retain IV-delivered ASC for a substantial amount of time, with no evidence of the significant cell distribution to other organs at this time point. These findings provide optimization of cell-based and cell-free therapy for the treatment of ARDS, including occurrences of ARDS caused by upper respiratory tract infections such as SARS and MERS.Type: GrantFiled: May 6, 2015Date of Patent: December 4, 2018Assignees: Indiana University Research and Technology Corporation, The United States of America Department of Veteran Affairs As Represented By The Technology Transfer ProgramInventors: Keith March, Natalia Bogatcheva
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Publication number: 20150320801Abstract: Disclosed herein is that the systemic administration of ASC conditioned media diminished LPS-induced lung injury by inhibiting epithelial permeability, neutrophil inflammatory response, and secretion of pro-inflammatory TNF?. It is also shown that ARDS lung is able to retain IV-delivered ASC for a substantial amount of time, with no evidence of the significant cell distribution to other organs at this time point. These findings provide optimization of cell-based and cell-free therapy for the treatment of ARDS, including occurrences of ARDS caused by upper respiratory tract infections such as SARS and MERS.Type: ApplicationFiled: May 6, 2015Publication date: November 12, 2015Inventors: Keith March, Natalia Bogatcheva
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Publication number: 20120100112Abstract: The present invention provides methods for treating patients with acute or chronic lung disease or injury to the lungs including injury caused by exposure to cigarette smoke other irritants or another cause of pulmonary distress. Typical conditions that can be treated include conditions that cause inflammation in the lung or the death of lung endothelial cells. Treatment of other conditions such as compromised bone marrow function and cachexia can also be treated by the inventive methods disclosed herein. These methods including contacting Adipose Stem Cells (ASC) or media conditioned by contact with ASC (ASC-CM) or various factors secreted by the same including the media or components of the media with lung tissue and cells. In some instances the ASC used is harvested from the patient's own adipose tissue while in other instances the source is an exogenous donor.Type: ApplicationFiled: April 20, 2010Publication date: April 26, 2012Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: Keith March, Irina Petrache
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Patent number: 7686821Abstract: The invention provides a device having two components: a needle advancing apparatus slidable longitudinally along a catheter to advance needles into a tissue membrane, such as a blood vessel wall, around an opening in the membrane; and, a suture retrieval assembly insertable through the catheter beyond a distal side of the tissue membrane. The needle advancing apparatus advances suture through the tissue wall. The suture retrieval assembly grabs the suture on the distal side of the tissue membrane for extraction thereof through the opening in the tissue membrane. A method for suturing a membrane beneath the patient's skin is also disclosed.Type: GrantFiled: January 27, 2006Date of Patent: March 30, 2010Assignee: Indiana University Research & Technology CorporationInventors: David Hathaway, Brian Patton, Keith March
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Patent number: 7670349Abstract: The invention provides a device having two components: a needle advancing apparatus slidable longitudinally along a catheter to advance needles into a tissue membrane, such as a blood vessel wall, around an opening in the membrane; and, a suture retrieval assembly insertable through the catheter beyond a distal side of the tissue membrane. The needle advancing apparatus advances suture through the tissue wall. The suture retrieval assembly grabs the suture on the distal side of the tissue membrane for extraction thereof through the opening in the tissue membrane. A method for suturing a membrane beneath the patient's skin is also disclosed.Type: GrantFiled: February 20, 2007Date of Patent: March 2, 2010Assignee: Indiana University Research & Technology CorporationInventors: David Hathaway, Brian Patton, Keith March
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Publication number: 20070135823Abstract: The invention provides a device having two components: a needle advancing apparatus slidable longitudinally along a catheter to advance needles into a tissue membrane, such as a blood vessel wall, around an opening in the membrane; and, a suture retrieval assembly insertable through the catheter beyond a distal side of the tissue membrane. The needle advancing apparatus advances suture through the tissue wall. The suture retrieval assembly grabs the suture on the distal side of the tissue membrane for extraction thereof through the opening in the tissue membrane. A method for suturing a membrane beneath the patient's skin is also disclosed.Type: ApplicationFiled: February 20, 2007Publication date: June 14, 2007Inventors: David Hathaway, Brian Patton, Keith March
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Publication number: 20060259047Abstract: The invention provides a device having two components: a needle advancing apparatus slidable longitudinally along a catheter to advance needles into a tissue membrane, such as a blood vessel wall, around an opening in the membrane; and, a suture retrieval assembly insertable through the catheter beyond a distal side of the tissue membrane. The needle advancing apparatus advances suture through the tissue wall. The suture retrieval assembly grabs the suture on the distal side of the tissue membrane for extraction thereof through the opening in the tissue membrane. A method for suturing a membrane beneath the patient's skin is also disclosed.Type: ApplicationFiled: January 27, 2006Publication date: November 16, 2006Inventors: David Hathaway, Brian Patton, Keith March
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Patent number: 7060078Abstract: The invention provides a device having two components: a needle advancing apparatus slidable longitudinally along a catheter to advance needles into a tissue membrane, such as a blood vessel wall, around an opening in the membrane; and, a suture retrieval assembly insertable through the catheter beyond a distal side of the tissue membrane. The needle advancing apparatus advances suture through the tissue wall. The suture retrieval assembly grabs the suture on the distal side of the tissue membrane for extraction thereof through the opening in the tissue membrane. A method for suturing a membrane beneath the patient's skin is also disclosed.Type: GrantFiled: November 13, 2001Date of Patent: June 13, 2006Assignee: Indiana University Research and Technology CorporationInventors: David Hathaway, Brian Patton, Keith March
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Publication number: 20050250202Abstract: The present invention provides isolated adipose derived stromal cells and methods of use thereof.Type: ApplicationFiled: March 19, 2003Publication date: November 10, 2005Inventors: Keith March, Jalees Rehman
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Publication number: 20030216678Abstract: A method for inducing vascular remodeling and related methods for treating patients having diseased vasculature. The method of inducing remodeling of the vascular system includes altering the blood flow dynamics in portions of the vascular system via mechanical mechanisms. Remodeling of certain coronary vasculature may be induced by creating a passage in a heart wall between a heart chamber and a blood vessel so as to permit blood flow communication, for example, direct blood flow communication, between the chamber and the vessel. A method of inducing vascular remodeling may include providing a blood flow passage between a heart chamber and the coronary vessel, or other flow dynamics altering structure, such that enlargement of at least a portion of the coronary vessel occurs.Type: ApplicationFiled: March 17, 2003Publication date: November 20, 2003Inventors: Keith March, Richard Popp, Peter Fitzgerald, Patrick Cahalan, Daniel Burkhoff, Laurence Roth, Nancy Briefs, William Santamore, Robert Swain, Peter Boekstegers, Vincent Pompili
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Publication number: 20020082613Abstract: The invention provides a device having two components: a needle advancing apparatus slidable longitudinally along a catheter to advance needles into a tissue membrane, such as a blood vessel wall, around an opening in the membrane; and, a suture retrieval assembly insertable through the catheter beyond a distal side of the tissue membrane. The needle advancing apparatus advances suture through the tissue wall. The suture retrieval assembly grabs the suture on the distal side of the tissue membrane for extraction thereof through the opening in the tissue membrane. A method for suturing a membrane beneath the patient's skin is also disclosed.Type: ApplicationFiled: November 13, 2001Publication date: June 27, 2002Inventors: David Hathaway, Brian Patton, Keith March
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Patent number: 6348059Abstract: The invention provides a device having two components: a needle advancing apparatus slidable longitudinally along a catheter to advance needles into a tissue membrane, such as a blood vessel wall, around an opening in the membrane; and, a suture retrieval assembly insertable through the catheter beyond a distal side of the tissue membrane The needle advancing apparatus advances suture through the tissue wall. The suture retrieval assembly grabs the suture on the distal side of the tissue membrane for extraction thereof through the opening in the tissue membrane. A method for suturing a membrane beneath the patient's skin is also disclosed.Type: GrantFiled: April 20, 2000Date of Patent: February 19, 2002Assignee: Advanced Research & Technology Institute, Inc.Inventors: David Hathaway, Brian Patton, Keith March
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Patent number: 6132440Abstract: The invention provides a device having two components: a needle advancing apparatus slidable longitudinally along a catheter to advance needles into a tissue membrane, such as a blood vessel wall, around an opening in the membrane; and, a suture retrieval assembly insertable through the catheter beyond a distal side of the tissue membrane. The needle advancing apparatus advances suture through the tissue wall. The suture retrieval assembly grabs the suture on the distal side of the tissue membrane for extraction thereof through the opening in the tissue membrane. A method for suturing a membrane beneath the patient's skin is also disclosed.Type: GrantFiled: September 22, 1998Date of Patent: October 17, 2000Assignee: Advanced Research & Technology InstituteInventors: David Hathaway, Brian Patton, Keith March
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Patent number: 5304184Abstract: The invention provides a device having two components: a needle advancing apparatus slidable longitudinally along a catheter to advance needles into a tissue membrane, such as a blood vessel wall, around an opening in the membrane; and, a suture retrieval assembly insertable through the catheter beyond a distal side of the tissue membrane. The needle advancing apparatus advances suture through the tissue wall. The suture retrieval assembly grabs the suture on the distal side of the tissue membrane for extraction thereof through the opening in the tissue membrane. A method for suturing a membrane beneath the patient's skin is also disclosed.Type: GrantFiled: October 19, 1992Date of Patent: April 19, 1994Assignee: Indiana University FoundationInventors: David Hathaway, Brian Patton, Keith March