Abstract: The present invention relates to a method for sensitizing a disease cell expressing the epidermal growth factor receptor (EGFR) to a tyrosine kinase inhibitor selective or specific for EGFR and/or its signalling pathway, the method comprising contacting the cell with a miR-7 miRNA, a precursor or variant thereof, or a miRNA comprising a seed region comprising the sequence GGAAGA.

Abstract: A pressure balance seal includes a sealing surface facing an inward radial direction, and a stator interface comprising at least one surface interfacing with a stator. The pressure balance seal further includes a friction reducing feature. The friction reducing feature includes a cavity on the sealing surface. The cavity is configured to receive a fluid such that a normal force acting on the pressure balance seal is counterbalanced by a force generated by a pressure of the fluid.

Abstract: The present invention relates to a method for modulating the expression and/or activity of an epidermal growth factor receptor (EGFR) ligand in a cell or tissue, the method comprising contacting the cell or tissue with a miR-7 miRNA, a pre-cursor or variant thereof, a miRNA comprising a seed region comprising the sequence GGAAGA, or an antagonist of any such miRNA.

Abstract: Based on received data descriptive of an event, a hierarchical data structure is constructed comprising structural elements associated with components of an event. A file folder hierarchy corresponding to the hierarchical data structure is created. User interfaces facilitate user access to files and folders in the hierarchies. Certain documents may be designated as documents of record and access to those documents is limited to processes that will not modify the original electronic document, thereby preserving it. Facilities for creating working copies of documents of records and associating them within the hierarchies are provided. A scanning information sheet that may have an electronically readable data imprint containing information about a document to be scanned is described for facilitating the migration of paper documents into an electronic file management system.

Abstract: This document describes tools useful in relaying a data stream from a data device to a network tunnel, such as by injecting in-band control messages without impacting a data rate. For example, the tools may receive data packets on a first link and then relay the data packets to a data device on a second link. While doing so, the tools may periodically free an amount of link time by reducing the length of the relayed data packets by reducing the length of a header of each data packet. The tools may then consume the freed link time by sending a control message on the second link to the data device.

Abstract: Based on received data descriptive of an event, a hierarchical data structure is constructed comprising structural elements associated with components of an event. A file folder hierarchy corresponding to the hierarchical data structure is created. User interfaces facilitate user access to files and folders in the hierarchies. Certain documents may be designated as documents of record and access to those documents is limited to processes that will not modify the original electronic document, thereby preserving it. Facilities for creating working copies of documents of records and associating them within the hierarchies are provided. A scanning information sheet that may have an electronically readable data imprint containing information about a document to be scanned is described for facilitating the migration of paper documents into an electronic file management system.

Abstract: Systems and methods for the automatic scoring of a vocal performance are provided. The systems and methods for providing feedback and scoring a vocal performance generally relate to receiving/processing a user's vocals, measuring the various performance qualities of the performance according stored evaluation policies and rendering a score according to stored scoring policies.

Abstract: A blade sharpening assembly generally including a pair of clamping members disposable in coextensive relationship, each providing end portions for receiving a blade therebetween with a cutting edge thereof disposed beyond the ends thereof; means interengaging the clamping members functional as a fulcrum in permitting the end portions to displace in clamping a blade therebetween; means interconnecting the clamping members for angularly displacing the clamping members about the fulcrum; a guide member pivotally connected to a second end portion of each of the clamping members, pivotal between a first position disposed coextensively with a connected clamping member, and a second position at an angle relative to the connected clamping member, alignable with the guide member of the other of the clamping members, when the clamping members are disposed in coextensive; means interconnectable between the guide members when the guide members are disposed in alignment for releasably retaining the guide members in alignm

Abstract: A turbocharger compressor bypass valve is disclosed. In one example, the compressor bypass valve operates inversely proportional to engine throttle operation. The approach may simplify compressor bypass valve control and reduced engine system complexity.

Abstract: A support for an aircraft seat, table or other piece of equipment has a lower support link that sweeps out a lateral arc. The lower support link cooperates with a conventional linear track to support the piece of equipment. The linear track provides fore/aft movement substantially orthogonal to a line tangent to the center of the lateral arc. A pilot link is operatively attached to the piece of equipment to form a four-bar linkage that maintains the equipment in a predetermined rotational attitude as the lower support link sweeps out its lateral arc.

Abstract: An aspirating face seal includes a primary seal, a secondary seal, and a biasing device. The primary seal includes a first seal component and a second seal component. The first seal component is configured to be coupled to a rotor and rotatable with the rotor. The secondary seal includes a plurality of flexible elements and configured to be disposed between the second seal component and a stator housing. A biasing device is coupled to the second seal component such that the second seal component is biased along an axial direction away from the first seal component during a non-operating condition.

Abstract: A brush seal assembly for turbomachinery having a rotor can include a stationary seal component, a floating seal component coupled to the stationary seal component and circumferentially angled bristles arranged in a bristle pack, disposed in the floating seal component and extended axially with respect to the rotor.

Abstract: Apparatus for analysing non-deterministic results of a search query of data, comprising a processor and a user interface, the processor being operably in communication with a plurality of data sources and adapted to communicate with the user interface which enables the user to query the content of the data sources, wherein the processor is adapted to determine the probable relevance of at least the part of a searched data source for a user query and the user interface is adapted to present to the user the search results in a form comprising two or more portlets, wherein the portlets comprises two or more of: a portlet presenting the search results (suchas search strings) for a data source(s); a portlet presenting the data source (such as by source name) of a data soruce(s); a portlet presenting a data source filter tree for selecting currently active source(s); a portlet presenting the hit(s) of a search query for a data source; a portlet presenting the hit location within a data source; and at least one of t

Abstract: Packet switch operating methods and packet switches receive a plurality of packets using a forwarding plane of the packet switch. Each packet of the plurality conforms to a different one of a plurality of forwarding information formats. The methods and packet switches modify each packet of the plurality to conform to a common forwarding information format instead of a respective one of the plurality of forwarding information formats and forward the modified packets of the plurality to a control plane of the packet switch.

Abstract: Embodiments pertain to simulator circuitry, particularly to simulator circuitry configured to simulate an electric vehicle and test an electric vehicle charger. A test unit is configured to simulate a GFI current via modulator and to simulate electric vehicle loads via switched and combined resistor loads. The test unit provides for reprogramming of the electric vehicle charger via a pilot line. The test unit self-confirms its usability via associating received codes.

Abstract: An aircraft seat has an adjustable armrest in which the armrest platform is supported by a hinged attachment to an armrest support member. The hinged attachment between the armrest platform and the arm support member is located at the wrist-end of the arm support member near the aircraft control stick. The armrest platform and the armrest support are locked into position by means of telescoping struts that are controlled at the wrist-end of the arm platform member. The telescoping struts can be selectively locked to create triangular and/or quadrilateral trusses that lock the armrest firmly into position and may include springs or other elements to bias the armrest platform up and forward so that the armrest “floats” when the telescoping struts re released.

Abstract: Embodiments pertain to simulator circuitry, particularly to simulator circuitry configured to simulate an electric vehicle and test an electric vehicle charger (110). A test unit (210) is configured to simulate a GFI current via modulator (1623) and to simulate electric vehicle loads via switched and combined resistor loads (1800). The test unit (220) provides for reprogramming of the electric vehicle charger (110) via a pilot line (323). The test unit (220) self-confirms its usability via associating received codes (1300).

Abstract: This document describes tools that enable data network equipment to use its permitted data rate or physical maximum rate even if one of its links fail or it transmits more data on some links than others. To do so, the tools may track how much of a permitted data rate is used by a group of physical links. If the group is using more than the permitted data rate, the tools may limit the group to that rate. If some of the physical links in the group fail, the tools enable the group to use either its permitted data rate or the physical maximum rate of the group. In addition, the tools allow unique permitted data rates in two directions by a group of physical links. The tools may be used at ingress or egress modules within equipment depending upon the application and implementation.

Abstract: An exhaust gas recirculation (EGR) system for a vehicle is provided. The EGR system includes a turbine fluidly coupled downstream of an exhaust manifold and an EGR conduit including a first port coupled to an exhaust passage directly downstream of the turbine, an axis of the first port arrange at a non-perpendicular angle with respect to the rotation axis of the turbine and a second port coupled to an intake system.

Abstract: This invention includes methods and packet switches that translate a packet between a switching format and a transport format. One packet switch receives a packet intended for a destination port of a packet switch from a switching fabric of the packet switch and determines, based on the destination port, a treatment to be applied to the packet. The packet switch then applies the treatment to the packet prior to forwarding the packet to the destination port. The treatment may include adding a transport identifier to the packet.