Patents by Inventor Keith Moravick
Keith Moravick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11966086Abstract: A first time/temperature data set includes temperatures and time stamps recorded at time intervals during a first thermal cycling process and a time stamp for each time interval, and a second time/temperature data set includes temperatures and time stamps recorded at time intervals during a second thermal cycling process. Signal emissions at different signal detecting positions are sequentially measured at different time intervals to generate first and second time/signal emission data sets for receptacles subject to the first and second thermal cycling processes, respectively. Signal emissions of receptacles subject to the first thermal cycling process are synchronized with specific temperatures of the first thermal cycling process by comparing time stamps of the first time/signal emission data set for each receptacle with the time stamps of the first time/temperature data set that correspond with the specific temperature.Type: GrantFiled: June 1, 2022Date of Patent: April 23, 2024Assignee: GEN-PROBE INCORPORATEDInventors: David Buse, David Howard Combs, Norbert D. Hagen, David Opalsky, Bruce Richardson, Anita Prasad, Keith Moravick, Tyler Moore
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Publication number: 20240035079Abstract: An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder that includes multiple receptacle wells. Each well can receive a receptacle and has a through-hole extending from an inner surface of the well to an outer surface of the holder. The apparatus includes multiple optical fibers, and each optical fiber has a first end in optical communication with an associated well and a second end in optical communication with an excitation signal source and/or an emission signal detector. The first end of each optical fiber is moveable with respect to the through-hole. A cover is movable between an open position and a closed position relative to the receptacle holder, and the first end of each optical fiber moves with respect to the through-hole of the associated well as the cover moves to the open or closed position or when the cover moves into or out of contact with any receptacles within the wells.Type: ApplicationFiled: October 13, 2023Publication date: February 1, 2024Applicant: Gen-Probe IncorporatedInventors: David BUSE, David Howard COMBS, Norbert D. HAGEN, David OPALSKY, Bruce RICHARDSON, Anita PRASAD, Keith MORAVICK, Tyler MOORE, Byron J. KNIGHT
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Publication number: 20230416811Abstract: An apparatus including a thermally-conductive receptacle holder having a row of receptacle wells. Each receptacle well has an inner surface defined to receive a receptacle, and each receptacle well has a through-hole extending between the inner and outer surfaces thereof. The apparatus further includes one or more thermal elements for altering a temperature(s) of the receptacle holder, where the one or more thermal element are in contact with a side surface of the receptacle holder. There are two or more thermistors disposed in contact with the receptacle holder and a channel disposed within the side surface and containing wires and/or electrical connections for the two or more thermistors.Type: ApplicationFiled: September 11, 2023Publication date: December 28, 2023Inventors: David BUSE, David H. COMBS, Norbert D. HAGEN, David OPALSKY, Bruce RICHARDSON, Anita PRASAD, Keith MORAVICK, Tyler MOORE
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Patent number: 11840727Abstract: Multiple receptacles containing a reaction mixture are transported to corresponding receptacle wells of a thermally-conductive receptacle holder in thermal communication with a support that is in thermal communication with a heat sink. The heat sink is pre-heated to a temperature above ambient temperature, and the temperature of the receptacle holder is cycled. Optical communication is established between each of the receptacle wells and an excitation signal source and an emission signal detector during cycling, and whether an emission signal is emitted from any of the receptacles is determined as an indication of the presence of a target nucleic acid.Type: GrantFiled: September 22, 2020Date of Patent: December 12, 2023Assignee: GEN-PROBE INCORPORATEDInventors: David Buse, David Howard Combs, Norbert D. Hagen, David Opalsky, Bruce Richardson, Anita Prasad, Keith Moravick, Tyler Moore, Byron J. Knight
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Patent number: 11788128Abstract: An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder with front and back surfaces. The front surface includes a row of receptacle wells, and an outer surface of each well has a frustoconical shape, an inner surface of each well receives a receptacle, and each well has a through-hole extending between the inner and outer surfaces thereof. One or more thermal elements in contact with the back surface of the holder alter a temperature(s) of the holder. The apparatus includes multiple optical fibers, and each optical fiber provides optical communication between one of the wells and an excitation signal source and/or an emission signal detector. A first end of each optical fiber is disposed outside, within, or extends through the through-hole of a corresponding well, and a second end of each optical fiber is in optical communication with the excitation signal source and/or the emission signal detector.Type: GrantFiled: September 23, 2020Date of Patent: October 17, 2023Assignee: GEN-PROBE INCORPORATEDInventors: David Buse, David Howard Combs, Norbert D. Hagen, David Opalsky, Bruce Richardson, Anita Prasad, Keith Moravick, Tyler Moore
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Patent number: 11692220Abstract: An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder with multiple receptacle wells. Each well has a through-hole extending from an inner surface of the well to an outer surface of the holder. A cover is rotatable between an open position and a closed position relative to the holder and is configured to exert a force onto any receptacles in the wells when the cover is in the closed position. The apparatus includes multiple optical fibers, and each of the optical fibers provides optical communication between one of the wells and an excitation signal source and/or an emission signal detector. A thermal element is positioned between a thermally-conductive support and the receptacle holder.Type: GrantFiled: September 21, 2020Date of Patent: July 4, 2023Assignee: GEN-PROBE INCORPORATEDInventors: David Buse, David Howard Combs, Norbert D. Hagen, David Opalsky, Bruce Richardson, Anita Prasad, Keith Moravick, Tyler Moore, Byron J. Knight
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Publication number: 20230035908Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.Type: ApplicationFiled: March 28, 2022Publication date: February 2, 2023Inventors: Elizabeth A. Holmes, Shaunak Roy, Ian Gibbons, Shize Daniel Qi, Edmond Ku, Chris Todd, Melissa Takahashi, Bruce Johnson, Jeff Fenton, Keith Moravick, Uwe Springborn, Anthony Delacruz
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Publication number: 20220291454Abstract: A first time/temperature data set includes temperatures and time stamps recorded at time intervals during a first thermal cycling process and a time stamp for each time interval, and a second time/temperature data set includes temperatures and time stamps recorded at time intervals during a second thermal cycling process. Signal emissions at different signal detecting positions are sequentially measured at different time intervals to generate first and second time/signal emission data sets for receptacles subject to the first and second thermal cycling processes, respectively. Signal emissions of receptacles subject to the first thermal cycling process are synchronized with specific temperatures of the first thermal cycling process by comparing time stamps of the first time/signal emission data set for each receptacle with the time stamps of the first time/temperature data set that correspond with the specific temperature.Type: ApplicationFiled: June 1, 2022Publication date: September 15, 2022Applicant: Gen-Probe IncorporatedInventors: David Buse, David Combs, Norbert D. Hagen, David Opalsky, Bruce Richardson, Anita Prasad, Keith Moravick, Tyler Moore
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Patent number: 11434521Abstract: A method for performing a nucleic acid amplification assay employs a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.Type: GrantFiled: February 10, 2022Date of Patent: September 6, 2022Assignee: GEN-PROBE INCORPORATEDInventors: David A. Buse, David Howard Combs, Byron J. Knight, Norbert D. Hagen, David Opalsky, Jason F. Rhubottom, Keith Moravick, Tyler Moore, Anita Prasad, Bruce Richardson
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Publication number: 20220186208Abstract: Disclosed herein are methods and devices for preparing a sample of nucleic acid molecules from a biological sample. The methods and devices may perform similarly to or better than standard sample preparation methods. The nucleic acid molecules prepared using the methods and devices provided herein may be utilized for downstream applications, including polymerase chain reaction (PCR).Type: ApplicationFiled: October 22, 2021Publication date: June 16, 2022Inventors: David D. SWENSON, Gregory C. LONEY, Valeria REVILLA, Adrienne C. LAM, Helen HUANG, Colin KELLY, Victor BRIONES, Brian CIOPYK, Boris ANDREYEV, Adam DE LA ZERDA, Keith MORAVICK, Jesus CHING, Jennifer ALBRECHT, Ryan CENA, Edward BIBA, Jonathan HONG
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Publication number: 20220162677Abstract: A method for performing a nucleic acid amplification assay employs a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.Type: ApplicationFiled: February 10, 2022Publication date: May 26, 2022Applicant: Gen-Probe IncorporatedInventors: David A. Buse, David Howard Combs, Byron J. Knight, Norbert D. Hagen, David Opalsky, Jason F. Rhubottom, Keith Moravick, Tyler Moore, Anita Prasad, Bruce Richardson
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Patent number: 11287421Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.Type: GrantFiled: April 12, 2018Date of Patent: March 29, 2022Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Shaunak Roy, Ian Gibbons, Shize Daniel Qi, Edmond Ku, Chris Todd, Melissa Takahashi, Bruce Johnson, Jeff Fenton, Keith Moravick, Uwe Springborn, Anthony Delacruz
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Patent number: 11279967Abstract: A system for performing a nucleic acid amplification assay that includes a receptacle holder formed from a thermally conductive material and having a receptacle well for receiving a lower portion of a vial; a thermal element for cycling the temperature of the receptacle holder; a signal detection module in optical communication with the receptacle well; and a robotic pipettor. The receptacle holder supports a capped vial having a plastic, opaque cap in a snap-fit with a single plastic vial containing a nucleic acid amplification reagent. An upper portion of the cap includes a probe recess that is configured to be removably engaged by an end of a probe of the robotic pipettor. A lower portion of the vial is contained within the receptacle well, and the cap is situated above a top surface of the receptacle holder.Type: GrantFiled: September 29, 2020Date of Patent: March 22, 2022Assignee: GEN-PROBE INCORPORATEDInventors: David A. Buse, David Howard Combs, Byron J. Knight, Norbert D. Hagen, David Opalsky, Jason F. Rhubottom, Keith Moravick, Tyler Moore, Anita Prasad, Bruce Richardson
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Patent number: 11230733Abstract: Receptacles containing a reaction mixture are transported to receptacle wells of a thermally conductive receptacle holder, and the temperature of the holder is cycled with a thermoelectric device situated between a support and a first side of the holder while a first force is applied onto a second side of the holder. Optical communication between each well and an excitation signal source and an emission signal detector is established to determine whether an emission signal is emitted from any of the receptacles during temperature cycling as an indication of the presence of a target nucleic acid. The thermoelectric device may be situated between an upright portion of the support and the first side of the holder. A second force may be applied onto a top end of each receptacle in the holder by a cover moveable with respect to the receptacles between an open position and a closed position.Type: GrantFiled: September 18, 2020Date of Patent: January 25, 2022Assignee: GEN-PROBE INCORPORATEDInventors: David Buse, David Howard Combs, Norbert D. Hagen, David Opalsky, Bruce Richardson, Anita Prasad, Keith Moravick, Tyler Moore, Byron J. Knight
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Patent number: 11193119Abstract: Disclosed herein are methods and devices for preparing a sample of nucleic acid molecules from a biological sample. The methods and devices may perform similarly to or better than standard sample preparation methods. The nucleic acid molecules prepared using the methods and devices provided herein may be utilized for downstream applications, including polymerase chain reaction (PCR).Type: GrantFiled: November 9, 2018Date of Patent: December 7, 2021Assignee: Visby Medical, Inc.Inventors: David D. Swenson, Gregory C. Loney, Valeria Revilla, Adrienne C. Lam, Helen Huang, Colin Kelly, Victor Briones, Brian Ciopyk, Boris Andreyev, Adam De La Zerda, Keith Moravick, Jesus Ching, Jennifer Albrecht, Ryan Cena, Edward Biba, Jonathan Hong
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Patent number: 10961572Abstract: A thermally conductive receptacle holder includes a plurality of wells that each receive a receptacle. A cross-brace is mounted to a support to exert a force onto an outer surface of a compressive housing such that the compressive housing exerts a force onto the receptacle holder. An optical fiber associated with each well provides optical communication between the receptacle well and an excitation signal source and/or an emission signal detector.Type: GrantFiled: June 7, 2019Date of Patent: March 30, 2021Assignee: GEN-PROBE INCORPORATEDInventors: David Buse, David Howard Combs, Norbert D. Hagen, David Opalsky, Bruce Richardson, Anita Prasad, Keith Moravick, Tyler Moore
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Publication number: 20210062245Abstract: An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder that includes multiple receptacle wells. Each well can receive a receptacle and has a through-hole extending from an inner surface of the well to an outer surface of the holder. The apparatus includes multiple optical fibers, and each optical fiber has a first end in optical communication with an associated well and a second end in optical communication with an excitation signal source and/or an emission signal detector. The first end of each optical fiber is moveable with respect to the through-hole. A cover is movable between an open position and a closed position relative to the receptacle holder, and the first end of each optical fiber moves with respect to the through-hole of the associated well as the cover moves to the open or closed position or when the cover moves into or out of contact with any receptacles within the wells.Type: ApplicationFiled: September 21, 2020Publication date: March 4, 2021Applicant: Gen-Probe IncorporatedInventors: David BUSE, David Howard COMBS, Norbert D. HAGEN, David OPALSKY, Bruce RICHARDSON, Anita PRASAD, Keith MORAVICK, Tyler MOORE, Byron J. Knight
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Publication number: 20210032681Abstract: Multiple receptacles containing a reaction mixture are transported to corresponding receptacle wells of a thermally-conductive receptacle holder in thermal communication with a support that is in thermal communication with a heat sink. The heat sink is pre-heated to a temperature above ambient temperature, and the temperature of the receptacle holder is cycled. Optical communication is established between each of the receptacle wells and an excitation signal source and an emission signal detector during cycling, and whether an emission signal is emitted from any of the receptacles is determined as an indication of the presence of a target nucleic acid.Type: ApplicationFiled: September 22, 2020Publication date: February 4, 2021Applicant: Gen-Probe IncorporatedInventors: David BUSE, David Howard COMBS, Nobert D. HAGEN, David OPALSKY, Bruce RICHARDSON, Anita PRASAD, Keith MORAVICK, Tyler MOORE, Byron J. KNIGHT
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Publication number: 20210017576Abstract: An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder with front and back surfaces. The front surface includes a row of receptacle wells, and an outer surface of each well has a frustoconical shape, an inner surface of each well receives a receptacle, and each well has a through-hole extending between the inner and outer surfaces thereof. One or more thermal elements in contact with the back surface of the holder alter a temperature(s) of the holder. The apparatus includes multiple optical fibers, and each optical fiber provides optical communication between one of the wells and an excitation signal source and/or an emission signal detector. A first end of each optical fiber is disposed outside, within, or extends through the through-hole of a corresponding well, and a second end of each optical fiber is in optical communication with the excitation signal source and/or the emission signal detector.Type: ApplicationFiled: September 23, 2020Publication date: January 21, 2021Applicant: Gen-Probe IncorporatedInventors: David BUSE, David Howard COMBS, Norbert D. HAGEN, David OPALSKY, Bruce RICHARDSON, Anita PRASAD, Keith MORAVICK, Tyler MOORE
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Publication number: 20210017579Abstract: A system for performing a nucleic acid amplification assay comprises a thermally-conductive receptacle holder with one or more receptacle wells, each conforming to an outer surface of a lower portion of a vial. A through-hole extends from an inner surface of each well to an outer surface of the holder. A thermal element is positioned proximal to the holder for altering a temperature of the holder. A signal detection module is configured to generate an excitation signal directed through the through-hole of the well and detect an optical emission from a fluid contained in the vial supported by the well. At least one well supports a capped vial containing a reagent for a nucleic acid amplification assay and including an opaque cap sealing an open end of the vial. The lower portion of the vial is contained within a well, and the cap is situated above a top surface of the holder.Type: ApplicationFiled: September 29, 2020Publication date: January 21, 2021Applicant: Gen-Probe IncorporatedInventors: David A. Buse, David Howard Combs, Byron J. Knight, Norbert D. Hagen, David Opalsky, Jason F. Rhubottom, Keith Moravick, Tyler Moore, Anita Prasad, Bruce Richardson