Patents by Inventor Keith Morton
Keith Morton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250224745Abstract: A method for metering a small volume of liquid is provided that leverages a dynamic redistribution provided by surface tension. A sample is made to over fill a metering cup, and occupy part of a surrounding overflow chamber, while providing a free surface above the metering cup and a rim surrounding the cup. Then retraction of the overflow volume to a critical point causes redistribution of the sample and a cleaving of the sample into a metered volume within the cup, and an overflow volume that is extracted.Type: ApplicationFiled: January 9, 2025Publication date: July 10, 2025Applicant: National Research Council of CanadaInventors: Pun Pang Shiu, Kebin Li, Teodor Veres, Keith Morton
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Publication number: 20250085203Abstract: A technique is provided for incorporating pneumatic control in centrifugal microfluidics. The technique involves providing a chip controller that has pressurized fluid supply lines for coupling one or more pressurized chambers of the controller with ports of a microfluidic chip. At least part of the chip controller is mounted to a centrifuge for rotation with the chip. A flow control device is provided in each supply line for selectively controlling the pressurized fluid supply, and is electrically controlled. Bubble mixing, on and off-chip valving, and switching are demonstrated.Type: ApplicationFiled: March 9, 2022Publication date: March 13, 2025Applicant: National Research Council of CanadaInventors: Byeong-Ui MOON, Liviu CLIME, Daniel Brassard, Keith MORTON, Teodor VERES
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Publication number: 20240342708Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.Type: ApplicationFiled: March 19, 2024Publication date: October 17, 2024Inventors: Ryan Denomme, Lidija Malic, Daniel Brassard, Keith Morton, Teodor Veres
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Patent number: 11958048Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.Type: GrantFiled: February 27, 2022Date of Patent: April 16, 2024Assignee: National Research Council of CanadaInventors: Ryan Denomme, Lidija Malic, Daniel Brassard, Keith Morton, Teodor Veres
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Patent number: 11867320Abstract: In a polymeric microfluidic valve, an adhesion control surface with discrete micro- or nano-scale structured surfaces are separated by fluid filled voids at an interface between an elastomeric membrane seals against a substrate layer. The structured surfaces reduce adhesion between the membrane layer and the substrate layer and prevent permanent bonding, while at the same time providing a good balance of adhesion at the valve seat to provide a sealing engagement. Microstructured adhesion control surfaces on and around valve bodies permit opening the valve, by reducing contact surface area.Type: GrantFiled: March 4, 2019Date of Patent: January 9, 2024Assignee: National Research Council of CanadaInventors: Kebin Li, Keith Morton, Teodor Veres
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Patent number: 11753485Abstract: The present application relates to polymer microparticle-metal nanoparticle composites, to methods of preparing polymer microparticle-metal nanoparticle composites and to uses of such composites. The methods comprise introducing into a microfluidic device, a composition comprising: a cationic metal nanoparticle precursor; a polymer microparticle precursor that comprises a plurality of photopolymerizable groups; and a photoreducer-photoinitiator; then irradiating the composition under conditions to simultaneously reduce the cationic metal and polymerize the photopolymerizable groups to obtain the composite.Type: GrantFiled: September 25, 2018Date of Patent: September 12, 2023Assignee: National Research Council of CanadaInventors: Lidija Malic, Xuefeng Zhang, Keith Morton, Teodor Veres
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Patent number: 11661469Abstract: Disclosed is a method of preparing polymer film-metal composites and uses of such composites. The metal can be in the form of a nanoparticle or a film. The methods comprise depositing on a surface, a composition comprising: a cationic metal precursor; a polymer film precursor that comprises a plurality of photopolymerizable groups; and a photoreducer-photoinitiator; then irradiating the composition under conditions to simultaneously reduce the cationic metal and polymerize the photopolymerizable groups to obtain the composite on the surface.Type: GrantFiled: September 25, 2018Date of Patent: May 30, 2023Assignee: National Research Council of CanadaInventors: Lidija Malic, Xuefeng Zhang, Keith Morton, Teodor Veres
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Publication number: 20220274112Abstract: A technique for supplying droplet content of an oil-encapsulated (OE) digital microfluidic (D?F) network to a region that is sensitive to oil contact involves sealing off a boundary surrounding the sensitive region with a volume of liquid that is miscible with payload of the OE-droplets. The sensitive region may be an opening to a microfluidic channel, or a sensor surface. The sealing off may be provided by transporting an unencapsulated droplet over the OE-D?F chip, either from a reservoir prior to oil encapsulation of the reservoir, or from a non-oil encapsulated reservoir; or by injecting the liquid into the microfluidic channel. A suitable treatment of the boundary may anchor the liquid to the boundary, and prevent removal by ordinary OE-D?F operations. A remainder of the surfaces of unit cells the D?F chip may provide higher droplet contact angle.Type: ApplicationFiled: July 9, 2020Publication date: September 1, 2022Applicant: National Research Council of CanadaInventors: Daniel Brassard, Lidija MALIC, Keith MORTON, Teodor VERES
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Publication number: 20220221402Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.Type: ApplicationFiled: February 27, 2022Publication date: July 14, 2022Inventors: Ryan Denomme, Lidija Malic, Daniel Brassard, Keith Morton, Teodor Veres
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Patent number: 11278890Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.Type: GrantFiled: August 6, 2019Date of Patent: March 22, 2022Assignee: National Research Council of CanadaInventors: Ryan Denomme, Lidija Malic, Daniel Brassard, Keith Morton, Teodor Veres
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Publication number: 20220008924Abstract: A centrifugal microfluidic platform is combined with a stationary liquid pumping system which pumps liquids into microfluidic chips by dripping through a stationary dispensing nozzle without any physical contact or coupling between the nozzles and the microfluidic chips.Type: ApplicationFiled: November 12, 2019Publication date: January 13, 2022Applicant: National Research Council of CanadaInventors: Liviu CLIME, Keith MORTON, Daniel BRASSARD, Mathias GEISSLER, Jamal DAOUD, Harold HEBERT, Teodor VERES
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Patent number: 11149242Abstract: Systems, methods, and apparatuses of controlling fluid flow are disclosed. An apparatus includes a first microplate having a first open portion and defining one or more first wells therein, a second microplate having a second open portion and defining one or more second wells therein, and a pneumatic lid constructed of styrene ethylene butylene styrene (SEBS). The pneumatic lid extends over the first open portion and the second open portion and includes one or more microfluidic channels that fluidly couple the one or more first wells to the one or more second wells. The pneumatic lid provides an airtight seal over the first microplate and the second microplate.Type: GrantFiled: March 23, 2020Date of Patent: October 19, 2021Assignees: Essen Instruments, Inc., National Research Council of CanadaInventors: Kirk S. Schroeder, Bradley D. Neagle, Eric Endsley, Daniel Appledorn, Keith Morton
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Publication number: 20210299660Abstract: A plasmon resonance system, instrument, cartridge, and methods for analysis of analytes is disclosed. A PR system is provided that may include a DMF-LSPR cartridge that may support both digital microfluidic (DMF) capability and localized surface plasmon resonance (LSPR) capability for analysis of analytes. In some examples, the DMF portion of the DMF-LSPR cartridge may include an electrode arrangement for performing droplet operations, whereas the LSPR portion of the DMF-LSPR cartridge may include an LSPR sensor. In other examples, the LSPR portion of the DMF-LSPR cartridge may include an in-line reference channel, wherein the in-line reference channel may be a fluid channel including at least one functionalized LSPR sensor (or sample spot) and at least one non-functionalized LSPR sensor (or reference spot). Additionally, methods of using the PR system for analysis of analytes are provided.Type: ApplicationFiled: August 6, 2019Publication date: September 30, 2021Inventors: Ryan Denomme, Lidija Malic, Daniel Brassard, Keith Morton, Teodor Veres
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Patent number: 11071985Abstract: A centrifugal microfluidic chip mounting, kit and method include a swivel joint permitting a chip to rotate about an axis of the chip in a plane swept by a centrifuge, and a force applicator for controlling an angle of the swivel and for applying a force in proportion to a rotational rate of the centrifuge. The mounting includes: a blade part (18) that couples to, or defines, a blade (10) of a centrifuge at a radial distance from a centrifuge axis (12); a chip part (20) that holds the chip at an orientation having a normal not perpendicular to the axis; a one degree of freedom (DoF) joint (16) between the blade part and the chip part; and a force applicator (28) which bears on the chip part at a fixed set of one or more points, which do not surround, and are not surrounded by, the joint.Type: GrantFiled: May 26, 2015Date of Patent: July 27, 2021Assignee: National Research Council of CanadaInventors: Liviu Clime, Teodor Veres, Keith Morton
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Publication number: 20200408332Abstract: In a polymeric microfluidic valve, an adhesion control surface with discrete micro- or nano-scale structured surfaces are separated by fluid filled voids at an interface between an elastomeric membrane seals against a substrate layer. The structured surfaces reduce adhesion between the membrane layer and the substrate layer and prevent permanent bonding, while at the same time providing a good balance of adhesion at the valve seat to provide a sealing engagement. Microstructured adhesion control surfaces on and around valve bodies permit opening the valve, by reducing contact surface area.Type: ApplicationFiled: March 4, 2019Publication date: December 31, 2020Applicant: National Research Council of CanadaInventors: Kebin LI, Keith MORTON, Teodor VERES
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Publication number: 20200223999Abstract: The present application relates to polymer film-metal composites, to methods of preparing polymer film-metal composites and to uses of such composites. The metal can be in the form of a nanoparticle or a film. The methods comprise depositing on a surface, a composition comprising: a cationic metal precursor; a polymer film precursor that comprises a plurality of photopolymerizable groups; and a photoreducer-photoinitiator; then irradiating the composition under conditions to simultaneously reduce the cationic metal and polymerize the photopolymerizable groups to obtain the composite on the surface.Type: ApplicationFiled: September 25, 2018Publication date: July 16, 2020Inventors: Lidija Malic, Xuefeng Zhang, Keith Morton, Teodor Veres
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Publication number: 20200223948Abstract: The present application relates to polymer microparticle-metal nanoparticle composites, to methods of preparing polymer microparticle-metal nanoparticle composites and to uses of such composites. The methods comprise introducing into a microfluidic device, a composition comprising: a cationic metal nanoparticle precursor; a polymer microparticle precursor that comprises a plurality of photopolymerizable groups; and a photoreducer-photoinitiator; then irradiating the composition under conditions to simultaneously reduce the cationic metal and polymerize the photopolymerizable groups to obtain the composite.Type: ApplicationFiled: September 25, 2018Publication date: July 16, 2020Inventors: Lidija Malic, Xuefeng Zhang, Keith Morton, Teodor Veres
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Publication number: 20200224139Abstract: Systems, methods, and apparatuses of controlling fluid flow are disclosed. An apparatus includes a first microplate having a first open portion and defining one or more first wells therein, a second microplate having a second open portion and defining one or more second wells therein, and a pneumatic lid constructed of styrene ethylene butylene styrene (SEBS). The pneumatic lid extends over the first open portion and the second open portion and includes one or more microfluidic channels that fluidly couple the one or more first wells to the one or more second wells. The pneumatic lid provides an airtight seal over the first microplate and the second microplate.Type: ApplicationFiled: March 23, 2020Publication date: July 16, 2020Inventors: Kirk S. SCHROEDER, Bradley D. NEAGLE, Eric ENDSLEY, Daniel APPLEDORN, Keith MORTON
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Patent number: 10633624Abstract: Systems, methods, and apparatuses of controlling fluid flow are disclosed. An apparatus includes a first microplate having a first open portion and defining one or more first wells therein, a second microplate having a second open portion and defining one or more second wells therein, and a pneumatic lid constructed of styrene ethylene butylene styrene (SEBS). The pneumatic lid extends over the first open portion and the second open portion and includes one or more microfluidic channels that fluidly couple the one or more first wells to the one or more second wells. The pneumatic lid provides an airtight seal over the first microplate and the second microplate.Type: GrantFiled: July 1, 2019Date of Patent: April 28, 2020Assignees: ESSEN INSTRUMENTS, INC., NATIONAL RESEARCH COUNCIL OF CANADAInventors: Kirk S. Schroeder, Bradley D. Neagle, Eric Endsley, Daniel Appledorn, Keith Morton
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Publication number: 20190322972Abstract: Systems, methods, and apparatuses of controlling fluid flow are disclosed. An apparatus includes a first microplate having a first open portion and defining one or more first wells therein, a second microplate having a second open portion and defining one or more second wells therein, and a pneumatic lid constructed of styrene ethylene butylene styrene (SEBS). The pneumatic lid extends over the first open portion and the second open portion and includes one or more microfluidic channels that fluidly couple the one or more first wells to the one or more second wells. The pneumatic lid provides an airtight seal over the first microplate and the second microplate.Type: ApplicationFiled: July 1, 2019Publication date: October 24, 2019Inventors: Kirk S. SCHROEDER, Bradley D. NEAGLE, Eric ENDSLEY, Daniel APPLEDORN, Keith MORTON