Abstract: A process of making an amphoteric polymeric composition which process comprises dispersing particles of an ion exchange resin comprising either weakly basic or weakly acidic ionogenic groups in a solution comprising one or more monomers containing an ionogenic group, or organic precursor thereof, of opposite charge to the ionogenic groups of the ion exchange resin particle, wherein the ion exchange resin particle and the monomer are not of opposite charge, and a crosslinking agent comprising two or more vinylic or allylic groups; secondly polymerizing the monomer to give a macroporous crosslinked polymer matrix; and thirdly treating the polymeric composition to convert any organic precursors to ionogenic groups to form an amphoteric polymeric composition.