Patents by Inventor Keith Philip Wilson

Keith Philip Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for designing inhibitors of serine/threonine kinases and tyrosine kinases
    Patent number: 6849716
    Abstract: The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: February 1, 2005
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael Shin-San Su, Ted Fox, Keith Philip Wilson, Ursula A. Germann
  • Methods for designing inhibitors of serine/threonine kinases and tyrosine kinases
    Publication number: 20040259166
    Abstract: The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.
    Type: Application
    Filed: July 15, 2004
    Publication date: December 23, 2004
    Inventors: Michael Shin-San Su, Ted Fox, Keith Philip Wilson, Ursula A. Germann
  • Methods for designing inhibitors of serine/threonine kinases and tyrosine kinases
    Publication number: 20030165899
    Abstract: The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.
    Type: Application
    Filed: June 12, 2002
    Publication date: September 4, 2003
    Applicant: Vertex Pharmaceuticals, Inc.
    Inventors: Michael Shin-San Su, Ted Fox, Keith Philip Wilson, Ursula A. Germann
  • Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases
    Patent number: 6162613
    Abstract: The invention relates to methods for designing inhibitors of serine/threonine kinases and tyrosine kinases, particularly MAP kinases, through the use of ATP-binding site mutants of those kinases. The methods of this invention take advantage of the fact that the mutant kinases are capable of binding inhibitory compounds of other kinases with greater affinity than the corresponding wild-type kinase. The invention further relates to the mutant kinases themselves and crystallizable co-complexes of the mutant kinase and the inhibitory compound.
    Type: Grant
    Filed: February 18, 1998
    Date of Patent: December 19, 2000
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Michael Shin-San Su, Ted Fox, Keith Philip Wilson, Ursula A. Germann