Patents by Inventor Keith R. D'Alessio
Keith R. D'Alessio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11826485Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: GrantFiled: April 23, 2021Date of Patent: November 28, 2023Assignee: HyperBranch Medical Technology, Inc.Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Publication number: 20210275718Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: ApplicationFiled: April 23, 2021Publication date: September 9, 2021Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Patent number: 11027043Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: GrantFiled: June 5, 2020Date of Patent: June 8, 2021Assignee: HyperBranch Medical Technology, Inc.Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Patent number: 10952709Abstract: Provided is an extended length, flexible or bendable spray tip assembly for use with a multi-component surgical sealant. The tip assembly is particularly suited for use in surgical procedures having limited access to a surgical field, for example, neurosurgical procedures involving infratentorial, skull base, or transsphenoidal craniotomy, as well as the spine. The tip assembly can be used in combination with a multi-component delivery system or applicator.Type: GrantFiled: April 2, 2015Date of Patent: March 23, 2021Assignee: HyperBranch Medical Technology, Inc.Inventor: Keith R. D'Alessio
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Patent number: 10688216Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: GrantFiled: January 29, 2018Date of Patent: June 23, 2020Assignee: HyperBranch Medical Technology, Inc.Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Publication number: 20190001018Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: ApplicationFiled: January 29, 2018Publication date: January 3, 2019Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Patent number: 9878066Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: GrantFiled: July 18, 2016Date of Patent: January 30, 2018Assignee: HYPERBRANCH MEDICAL TECHNOLOGY, INC.Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Publication number: 20170049924Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: ApplicationFiled: July 18, 2016Publication date: February 23, 2017Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Patent number: 9393344Abstract: One aspect of the present invention generally relates to methods of sealing a wound or tissue plane or filling a void splace. In a preferred embodiment, the wound is an ophthalmic, pleural or dural wound. In certain instances, the compositions used to seal the wound or tissue plane comprises a polyalkyleneimine. In a preferred embodiment, the polyalkyleneimine is polyethyleneimine. Treatment of the polyethyleneimine with a cross-linking reagent causes the polyethyleneimine polymers to polymerize forming a seal. In certain instances, the cross-linking reagent is a polyethylene glycol having reactive terminal groups. In certain instances, the reactive terminal groups are activated esters, such as N-hydroxy succinimide ester. In certain instances, the reactive terminal groups are isocyanates. In certain instances, the polyethyleneimine has a lysine, cysteine, isocysteine or other nucleophilic group attached to the periphery of the polymer.Type: GrantFiled: January 11, 2007Date of Patent: July 19, 2016Assignee: HyperBranch Medical Technology, Inc.Inventors: Kenneth E. Stockman, Michael A. Carnahan, Keith R. D'Alessio, Mark W. Grinstaff
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Publication number: 20160030027Abstract: Aspects of the invention relate to an applicator which can house multiple components of a formulation in separate receptacles. In certain embodiments, an applicator of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, or any of the internal tissues.Type: ApplicationFiled: October 13, 2015Publication date: February 4, 2016Inventors: Jared D. G. Butlin, Keith R. D'Alessio
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Publication number: 20150282794Abstract: Provided is an extended length, flexible or bendable spray tip assembly for use with a multi-component surgical sealant. The tip assembly is particularly suited for use in surgical procedures having limited access to a surgical field, for example, neurosurgical procedures involving infratentorial, skull base, or transsphenoidal craniotomy, as well as the spine. The tip assembly can be used in combination with a multi-component delivery system or applicator.Type: ApplicationFiled: April 2, 2015Publication date: October 8, 2015Inventor: Keith R. D'Alessio
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Publication number: 20130338631Abstract: Aspects of the invention relate to an applicator which can house multiple components of a formulation in separate receptacles. In certain embodiments, an applicator of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, or any of the internal tissues.Type: ApplicationFiled: March 14, 2011Publication date: December 19, 2013Applicant: HyperBranch Medical Technology, Inc.Inventors: Jared D. G. Butlin, Keith R. D'Alessio
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Patent number: 8343183Abstract: Aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which components can then be easily combined at the time of use without assembly by the user. In certain embodiments, a device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, or any of the internal tissues. In certain embodiments, a device of the invention can be configured to apply a spray or a stream of a liquid formulation to a surface. In certain embodiments, a device of the invention can be configured to deliver the formulation through an endoscope or laparoscope.Type: GrantFiled: April 30, 2010Date of Patent: January 1, 2013Assignee: HyperBranch Medical Technology, Inc.Inventors: Keith R. D'Alessio, Matthew Justin Morton, John L. Manhard, Stephen William Cline, Jared Daniel Goodnow Butlin, John Conn
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Patent number: 8323262Abstract: Certain aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which can then be easily reconstituted at time of use without any assembly by the user. A device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, and any of the internal tissues. A device of the invention can be configured to apply a spray or a stream of liquid formulation onto a surface to be treated. A device of the invention can be configured to deliver the formulation through an endoscope or laparoscope.Type: GrantFiled: July 8, 2009Date of Patent: December 4, 2012Assignee: HyperBranch Medical Technology, Inc.Inventors: Keith R. D'Alessio, Jeffrey G. Clark, Roy R. B. Attride, Wai N. Chin, Robert M. Colonna, Tomas Matusaitis, Todd J. Taylor, Christopher R. Yahnker
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Patent number: 8262608Abstract: One aspect of the invention relates to an applicator system, and methods of use thereof, that can be used to house separately one or more liquids and one or more solids (e.g., components of a polymerizable hydrogel). In certain embodiments, the applicator systems are further designed to facilitate the mixing of the solids and liquids inside the applicator. In addition, in certain embodiments, the applicator systems are also designed to facilitate the application of the mixture to a surface.Type: GrantFiled: January 25, 2008Date of Patent: September 11, 2012Assignee: HyperBranch Medical Technology, Inc.Inventors: Jeffrey G. Clark, Keith R. D'Alessio
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Publication number: 20100280312Abstract: Aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which components can then be easily combined at the time of use without assembly by the user. In certain embodiments, a device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, or any of the internal tissues. In certain embodiments, a device of the invention can be configured to apply a spray or a stream of a liquid formulation to a surface. In certain embodiments, a device of the invention can be configured to deliver the formulation through an endoscope or laparoscope.Type: ApplicationFiled: April 30, 2010Publication date: November 4, 2010Applicant: HyperBranch Medical Technology, Inc.Inventors: Keith R. D'Alessio, Matthew J. Morton, John L. Manhard, Stephen W. Cline, Jared D.G Butlin, John Conn
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Publication number: 20100280547Abstract: One aspect of the invention relates to a simple, inexpensive applicator system which can be used for the delivery of a hydrogel formulation. In certain embodiments, the applicator system is suitable for use in sealing of dura mater, especially dura matter within the spinal column. In other embodiments, the applicator system may be used to repair cardiovascular defects, defects of the gall or urinary bladder, or repair of any of the other ducts within the body.Type: ApplicationFiled: April 30, 2010Publication date: November 4, 2010Applicant: HyperBranch Medical Technology, Inc.Inventors: Keith R. D'Alessio, Michael A. Carnahan, Jared D. G. Butlin
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Publication number: 20100010473Abstract: Certain aspects of the invention relate to an applicator, and methods of use thereof, which can house multiple component formulations in separate material receptacles, which can then be easily reconstituted at time of use without any assembly by the user. A device of the invention can be used for, but is not limited to, applying hydrogel formulations to dura mater, abdominal tissue in hernia repair, tissues near the spine, lung tissue, intestinal tissue, and any of the internal tissues. A device of the invention can be configured to apply a spray or a stream of liquid formulation onto a surface to be treated. A device of the invention can be configured to deliver the formulation through an endoscope or laparoscope.Type: ApplicationFiled: July 8, 2009Publication date: January 14, 2010Applicant: HyperBranch Medical Technology, Inc.Inventors: Keith R. D'Alessio, Jeffrey G. Clark, Roy R.B. Attride, Wai N. Chin, Robert M. Colonna, Tomas Matusaitis, Todd J. Taylor, Christopher R. Yahnker
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Patent number: 7516872Abstract: An applicator/dispenser for dispensing, mixing and/or applying a polymerizable monomeric adhesive or sealant material comprises: a body portion; an actuator movable relative to the body portion; a cavity in the body portion; and a piercing or breaking portion on the actuator. Movement of the actuator relative to the body portion moves the piercing or breaking portion into the cavity. When a container of adhesive or sealant material is at least partially disposed within the cavity, movement of the actuator relative to the body portion moves the piercing or breaking portion to rupture the container for mixing, dispensing and/or applying the adhesive or sealant material.Type: GrantFiled: September 3, 2004Date of Patent: April 14, 2009Assignee: Closure Medical Corp.Inventors: Eric J. Boone, Keith R. D'Alessio, John F. Goodman, Scott A. Keplinger, Anthony S. Voiers, Daniel J. Tomko, William F. Johnson, Jr.
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Publication number: 20080195040Abstract: One aspect of the invention relates to an applicator system, and methods of use thereof, that can be used to house separately one or more liquids and one or more solids (e.g., components of a polymerizable hydrogel). In certain embodiments, the applicator systems are further designed to facilitate the mixing of the solids and liquids inside the applicator. In addition, in certain embodiments, the applicator systems are also designed to facilitate the application of the mixture to a surface.Type: ApplicationFiled: January 25, 2008Publication date: August 14, 2008Applicant: HyperBranch Medical Technology, Inc.Inventors: Jeffrey A. Clark, Keith R. D'Alessio