Patents by Inventor Keith R. Fandrick

Keith R. Fandrick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing carboxamidine compounds
    Patent number: 9029592
    Abstract: The present invention relates to a process of making a compound of formula (I): Wherein, R1, R2, R4 and X are as defined herein.
    Type: Grant
    Filed: February 7, 2013
    Date of Patent: May 12, 2015
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Keith R. Fandrick, Joe Ju Gao, Jason Alan Mulder, Nitinchandra D. Patel, Xingzhong Zeng
  • PROCESS FOR THE PREPARATION OF AN HIV INTEGRASE INHIBITOR
    Publication number: 20140094609
    Abstract: The present invention is directed to an improved process for the preparation of Compounds of Formula (I), which are useful in the treatment of HIV infection. In particular, the present invention is directed to an improved process for the preparation of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid, which is useful in the treatment of HIV infection.
    Type: Application
    Filed: October 2, 2013
    Publication date: April 3, 2014
    Inventors: Brandon H. Brown, Xiang Wang, Keith R. Fandrick, Joe Ju Gao, Nizar Haddad, Serge R. Landry, Wenjie Li, Zhi-Hui Lu, Bo Qu, Diana C. Reeves, Carl Thibeault, Yongda Zhang
  • PROCESS FOR THE PREPARATION OF AN HIV INTEGRASE INHIBITOR
    Publication number: 20140094610
    Abstract: The present invention is directed to an improved process for the preparation of Compounds of Formula (I) or salts thereof which are useful in the treatment of HIV infection. In particular, the present invention is directed to an improved process for the preparation of (2S)-2-tert-butoxy-2-(4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl)acetic acid or salt thereof which is useful in the treatment of HIV infection.
    Type: Application
    Filed: October 3, 2013
    Publication date: April 3, 2014
    Inventors: Wenjie LI, Philomen DECROOS, Keith R. FANDRICK, Joe Ju GAO, Nizar HADDAD, Zhi-Hui LU, Bo QU, Sonia RODRIGUEZ, Chris H. SENANAYAKE, Yongda ZHANG, Wenjun TANG
  • PROCESS FOR PREPARING CARBOXAMIDINE COMPOUNDS
    Publication number: 20130211130
    Abstract: The present invention relates to a process of making a compound of formula (I): Wherein, R1, R2, R4 and X are as defined herein.
    Type: Application
    Filed: February 7, 2013
    Publication date: August 15, 2013
    Applicant: Boehringer Ingelheim International Gmbh
    Inventors: Keith R. FANDRICK, Joe Ju GAO, Jason Alan MULDER, Nitinchandra D. PATEL, Xingzhong ZENG
  • Synthesis of inhibitors of 11?-hydroxysteroid dehydrogenase type 1
    Patent number: 8487094
    Abstract: Disclosed are syntheses of 11?-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: July 16, 2013
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Keith R. Fandrick, Joe Ju Gao, Wenjie Li, Zhi-Hui Lu, Yongda Zhang
  • SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1
    Publication number: 20110269957
    Abstract: Disclosed are syntheses of 11?-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).
    Type: Application
    Filed: July 23, 2009
    Publication date: November 3, 2011
    Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
    Inventors: Keith R. Fandrick, Joe Ju Gao, Wenjie Li, Zhi-Hui Lu, Yongda Zhang