Patents by Inventor Keith R. Jerome

Keith R. Jerome has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240398984
    Abstract: Described herein are compositions and methods for reducing or eliminating latent herpes simplex virus type 2 (HSV-2) from an HSV-2-infected cell, or for reducing or eliminating latent HSV-2 reactivation in an HSV-2-infected cell, leading to a viable curative approach for latent HSV-2 infection. The composition comprises a plurality of viral vectors, wherein the viral vectors comprise a sequence encoding an HSV-2-specific meganuclease. The method comprises delivering to an HSV-2-infected cell a plurality of one or more viral vectors, wherein each of the one or more viral vectors includes a sequence encoding an HSV-2-specific meganuclease.
    Type: Application
    Filed: May 21, 2024
    Publication date: December 5, 2024
    Applicant: Fred Hutchinson Cancer Center
    Inventors: Keith R. Jerome, Barry L. Stoddard, Abigail R. Lambert
  • Publication number: 20240301372
    Abstract: Embodiments of the present disclosure are directed to methods and compositions for reducing or eliminating latent HSV-1 reactivation in a cell. In some embodiments, the method comprises delivering to an HSV-1-infected cell one or more self-complementary adeno-associated viruses (scAAV) comprising one or more sequences encoding one or more HSV-1-specific meganucleases. In some embodiments, the composition comprises one or more self-complementary adeno-associated viruses (scAAV) comprising one or more sequences encoding one or more HSV-1-specific meganucleases.
    Type: Application
    Filed: January 25, 2022
    Publication date: September 12, 2024
    Applicant: FRED HUTCHINSON CANCER CENTER
    Inventors: Keith R. Jerome, Barry L. Stoddard