Patents by Inventor Keith R. Laderoute

Keith R. Laderoute has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and composition for inhibiting cell proliferation and angiogenesis
    Publication number: 20120252773
    Abstract: A method is provided for treating a patient with a medical condition that involves angiogenesis or HIF-1 overexpression with a compound having the structure of formula (I) wherein Z, x, y, and R1 through R11 are as defined herein.
    Type: Application
    Filed: April 26, 2012
    Publication date: October 4, 2012
    Inventors: Khalid Amin, Joy M. Calaoagan, Wan-Ru Chao, Peter D. Hobbs, Keith R. Laderoute, Richard H. Peters, Masato Tanabe
  • Method for inhibiting inflammatory disease
    Patent number: 6433012
    Abstract: The present invention relates to methods for effectively inhibiting inflammatory diseases, such as Crohn's disease and ulcerative colitis. In other aspects, this invention relates to methods of reducing or inhibiting granulomas.
    Type: Grant
    Filed: September 6, 2000
    Date of Patent: August 13, 2002
    Assignees: Large Scale Biology Corp., SRI International
    Inventors: Daniel Tuse, Charles Hiebert, Keith R. Laderoute, Nahid Waleh
  • Tissue specific hypoxia regulated constructs
    Patent number: 6218179
    Abstract: Methods and compositions relating to chimeric genes containing (i) a tissue-specific promoter and (ii) a hypoxia response enhancer element, both of which are operably linked to a selected gene, such as a reporter gene, therapeutic gene (e.g., bcl-2, NOS, catalase and SOD), or deleterious gene are disclosed. Expression of the selected gene is enhanced in the target tissue under hypoxia conditions, such as conditions encountered during episodes of ischemia and reperfusion. The methods and compositions may be used as therapeutics and/or diagnostics.
    Type: Grant
    Filed: June 23, 1997
    Date of Patent: April 17, 2001
    Assignee: SRI International
    Inventors: Keith A. Webster, Nanette H. Bishopric, Brian Murphy, Keith R. Laderoute, Christopher J. Green
  • Methods for inhibiting angiogenesis
    Patent number: 6150407
    Abstract: The present invention relates to methods for effectively inhibiting unwanted angiogenesis. More particularly, this invention relates to methods of treating diseases that show unwanted angiogenesis and to delivering anti-angiogenic activity to a mammal. In other aspects this invention relates to methods of reducing the level of tumor necrosis factor .alpha..
    Type: Grant
    Filed: March 22, 1999
    Date of Patent: November 21, 2000
    Assignees: Large Scale Biology Corporation, SRI International
    Inventors: Daniel Tuse, Charles Hiebert, Keith R. Laderoute, Nahid Waleh