Patents by Inventor Keith R. Marotti

Keith R. Marotti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6511813
    Abstract: Disclosed are novel methods of using elongation factor p (efp) and related constituents of ribosomal complexes which comprise efp, the 50S ribosomal subunit, the 30S ribosomal subunit, the 70S initiation complex, and related proteins, cofactors and enzymes. Methods of identifying compounds which modulate prokaryotic elongation factor p and modify cell function are described. Both in vitro and in vivo methods for identifying compounds which modulate such constituents and affect cell function are described. Such identified compounds, including various antibiotics, which specifically affect cell growth, methods of treating various disorders with such compounds, and antiseptics containing such compounds are described. The present invention is also directed to methods and compounds that modulate prokaryotic elongation factor p.
    Type: Grant
    Filed: November 2, 2000
    Date of Patent: January 28, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Keith R. Marotti, Roger A. Poorman, Peter A. Wells, Dean L. Shinabarger
  • Patent number: 5275946
    Abstract: This invention relates to analogs of thrombolytic agents having a modified kringle domain. More specifically, this invention is directed to TPA type compounds wherein modifications occur in the kringle 1 and kringle 2 domains. This invention is also directed to analogs with one or more changes in the kringle domain of urokinase-type compounds. The compounds of this invention are pharmaceutically useful having particular use in the same manner as TPA and urokinase.
    Type: Grant
    Filed: June 7, 1991
    Date of Patent: January 4, 1994
    Assignee: Nederlandse Organisatie voor Toegepast-Natuurwetenschappelijk Onderzoek Tno
    Inventors: Nicole T. Hatzenbuhler, Keith R. Marotti, Edward F. Rehberg, Johan H. Verheyen
  • Patent number: 5106741
    Abstract: This invention discloses human tissue plasminogen activator (TPA) analogs. The analogs are TPA-like molecules that have had the native domain regions either rearranged, delected, added or a combination thereof. The analogs are the product of the expression of recombinant DNA also described herein. Additonally, the present invention described replication and expression plasmids containing the TPA-coding DNA sequences described above and suitable host microorganisms that are capable of expressing the TPA analogs after becoming transformed with an appropriate plasmid.
    Type: Grant
    Filed: June 12, 1991
    Date of Patent: April 21, 1992
    Assignee: The Upjohn Company
    Inventors: Keith R. Marotti, Edward F. Rehberg, Nicole Y. Theriault