Patents by Inventor Keith R. McCrea
Keith R. McCrea has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240066470Abstract: The present disclosure provides a filtration media comprising a combination of (i) a hollow fiber membrane and (ii) adsorption media. The disclosure further provides a device, the device comprising a filtration media, which filtration media includes a combination of (i) a hollow fiber membrane and (ii) adsorption media.Type: ApplicationFiled: September 20, 2023Publication date: February 29, 2024Inventors: Robert S. Ward, Keith R. McCrea
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Patent number: 11911551Abstract: Methods and devices are disclosed for the treatment of a subject suffering from drug intoxication by cleansing a contaminated sample from the subject with adsorption media. The adsorption media composition is selected for its antithrombogenic properties and for its ability to adhere to one or more drug targets to be reduced or eliminated. The media can further be held in a cartridge for use in extracorporeal treatments such as those of hemoperfusion. Contacting the contaminated sample from the subject with the absorption medium allows for the separation of a portion of the drug target from the sample, producing a cleansed sample that can be infused into the subject.Type: GrantFiled: August 28, 2020Date of Patent: February 27, 2024Assignee: ExThera Medical CorporationInventors: Robert S. Ward, Keith R. McCrea
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Patent number: 11306346Abstract: The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods.Type: GrantFiled: October 25, 2019Date of Patent: April 19, 2022Assignee: ExThera Medical CorporationInventors: Robert S. Ward, Keith R. McCrea
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Publication number: 20220072038Abstract: The present invention provides methods and devices for augmenting impaired glycocalyx barrier function in a subject in need thereof by contacting a sample (e.g., blood) obtained from the subject with a glycocalyx-mimetic adsorption media. The adsorption media includes glycosaminoglycan structures and, optionally, proteoglycan core proteins, which are conducive to enhancing and/or restoring the impaired glycocalyx barrier function in a sample. The contacted sample is subsequently separated from the adsorption media, producing a treated sample that can be infused into the subject. Methods and devices for treating a patient suffering from a disease associated with glycocalyx barrier dysfunction are also provided herein.Type: ApplicationFiled: November 15, 2021Publication date: March 10, 2022Applicant: ExThera Medical CorporationInventors: Robert S. Ward, Keith R. McCrea, Lakhmir (Mink) Chawla
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Patent number: 11123466Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non microporous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.Type: GrantFiled: August 27, 2018Date of Patent: September 21, 2021Assignee: ExThera Medical CorporationInventors: Robert S. Ward, Keith R. McCrea, Olle Larm, Lars Adolfsson
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Publication number: 20210008269Abstract: Methods and devices are disclosed for the treatment of a subject suffering from drug intoxication by cleansing a contaminated sample from the subject with adsorption media. The adsorption media composition is selected for its antithrombogenic properties and for its ability to adhere to one or more drug targets to be reduced or eliminated. The media can further be held in a cartridge for use in extracorporeal treatments such as those of hemoperfusion. Contacting the contaminated sample from the subject with the absorption medium allows for the separation of a portion of the drug target from the sample, producing a cleansed sample that can be infused into the subject.Type: ApplicationFiled: August 28, 2020Publication date: January 14, 2021Applicant: ExThera Medical CorporationInventors: Robert S. WARD, Keith R. McCREA
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Patent number: 10857283Abstract: The present technology relates to methods and devices for the removal of toxins and pathogens from infected blood of patients. In particular, devices are designed to be portable, wearable, disposable and self-contained extracorporeal devices that can be easily assembled from a kit.Type: GrantFiled: September 21, 2015Date of Patent: December 8, 2020Assignee: EXTHERA MEDICAL CORPORATIONInventors: Robert S Ward, Keith R McCrea
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Publication number: 20200338256Abstract: The present technology relates to methods and devices for the removal of toxins and pathogens from infected blood of patients. In particular, devices are designed to be portable, wearable, disposable and self-contained extracorporeal devices that can be easily assembled from a kit.Type: ApplicationFiled: July 7, 2020Publication date: October 29, 2020Applicant: ExThera Medical CorporationInventors: Robert S. Ward, Keith R. McCrea
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Patent number: 10786615Abstract: Methods and devices are disclosed for the treatment of a subject suffering from drug intoxication by cleansing a contaminated sample from the subject with adsorption media. The adsorption media composition is selected for its antithrombogenic properties and for its ability to adhere to one or more drug targets to be reduced or eliminated. The media can further be held in a cartridge for use in extracorporeal treatments such as those of hemoperfusion. Contacting the contaminated sample from the subject with the absorption medium allows for the separation of a portion of the drug target from the sample, producing a cleansed sample that can be infused into the subject.Type: GrantFiled: March 1, 2017Date of Patent: September 29, 2020Assignee: EXTHERA MEDICAL CORPORATIONInventors: Robert S. Ward, Keith R. McCrea
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Publication number: 20200056221Abstract: The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods.Type: ApplicationFiled: October 25, 2019Publication date: February 20, 2020Inventors: Robert S. WARD, Keith R. McCREA
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Patent number: 10487350Abstract: The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods.Type: GrantFiled: October 16, 2015Date of Patent: November 26, 2019Assignee: ExThera Medical CorporationInventors: Robert S. Ward, Keith R. McCrea
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Patent number: 10457974Abstract: The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods.Type: GrantFiled: November 2, 2016Date of Patent: October 29, 2019Assignee: ExThera Medical CorporationInventors: Robert S. Ward, Keith R. McCrea
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Publication number: 20180361050Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.Type: ApplicationFiled: August 27, 2018Publication date: December 20, 2018Applicant: EXTHERA MEDICAL CORPORATIONInventors: ROBERT S. WARD, Keith R. McCREA, Olle LARM, Lars ADOLFSSON
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Patent number: 10086126Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non microporous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.Type: GrantFiled: June 30, 2016Date of Patent: October 2, 2018Assignee: ExThera Medical CorporationInventors: Robert S Ward, Keith R McCrea, Olle Larm, Lars Adolfsson
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Publication number: 20180015120Abstract: Polymers having the formula R(LE)x wherein R is a polymeric core having a number average molecular weight of from 5000 to 7,000,000 daltons and having x endgroups, E is an endgroup covalently linked to polymeric core R by linkage L, L is a divalent oligomeric chain, having at least 5 identical repeat units, capable of self-assembly with L chains on adjacent molecules of the polymer, and the moieties (LE)x in the polymer may be the same as or different from one another. Design of monomers, oligomers, or other reactive structures otherwise analogous to known Self Assembled Monolayers but with at least one reactive chemical group capable of binding them to the terminus of a polymer, so that the thiol-free SAM analogue becomes the self-assembling surface modifying endgroup of that polymer. Use of the polymer to fabricate a configured article from the surface-modified polymer or a coating or topical treatment on an article made from another material.Type: ApplicationFiled: August 10, 2017Publication date: January 18, 2018Inventors: Robert S. WARD, Keith R. McCREA, James Parakka, Shanger Wang, Yuan Tian
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Publication number: 20170252502Abstract: Methods and devices are disclosed for the treatment of a subject suffering from drug intoxication by cleansing a contaminated sample from the subject with adsorption media. The adsorption media composition is selected for its antithrombogenic properties and for its ability to adhere to one or more drug targets to be reduced or eliminated. The media can further be held in a cartridge for use in extracorporeal treatments such as those of hemoperfusion. Contacting the contaminated sample from the subject with the absorption medium allows for the separation of a portion of the drug target from the sample, producing a cleansed sample that can be infused into the subject.Type: ApplicationFiled: March 1, 2017Publication date: September 7, 2017Inventors: ROBERT S. WARD, KEITH R. McCREA
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Publication number: 20170073727Abstract: The present invention provides an in vitro method for concentrating infectious pathogens found in a biological sample obtained from an individual who is suspected of being infected with the pathogens. Provided herein is also an in vitro method for reducing or eliminating blood cells from a sample obtained from an individual suspected to being infected with an infectious pathogen. The present invention also provides a method for diagnosing malaria and a method for determining if an individual is infected with a pathogen. Provided herein is also a concentrator and a kit for use with the methods.Type: ApplicationFiled: November 2, 2016Publication date: March 16, 2017Inventors: Robert S. WARD, Keith R. McCREA
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Publication number: 20160331886Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non micro-porous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.Type: ApplicationFiled: June 30, 2016Publication date: November 17, 2016Applicant: EXTHERA MEDICAL CORPORATIONInventors: ROBERT S. WARD, Keith R. McCrea, Olle Larm, Lars Adolfsson
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Patent number: 9408962Abstract: The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non microporous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.Type: GrantFiled: April 24, 2014Date of Patent: August 9, 2016Assignee: EXTHERA MEDICAL CORPORATIONInventors: Robert S. Ward, Keith R. McCrea, Olle Larm, Lars Adolfsson
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Publication number: 20160082177Abstract: The present technology relates to methods and devices for the removal of toxins and pathogens from infected blood of patients. In particular, devices are designed to be portable, wearable, disposable and self-contained extracorporeal devices that can be easily assembled from a kit.Type: ApplicationFiled: September 21, 2015Publication date: March 24, 2016Applicant: EXTHERA MEDICAL CORPORATIONInventors: ROBERT S. WARD, KEITH R. McCREA