Patents by Inventor Keith Rippel

Keith Rippel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080161327
    Abstract: The invention relates to substituted 9-alkyladenines of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1-R6 are defined as set forth in the specification. The invention is also directed to the use of such compounds to inhibit adenosine A1 receptor activation in a mammal. The compounds of the present invention are useful as diuretics, renal protectives against acute or chronic renal failure, as well as agents to improve the therapeutic outcome resulting from defibrillation or cardiopulmonary resuscitation by preventing post-resuscitation bradycardia, bradyarrythmia and cardioplegia, to restore cardiac function following a cardioplegic procedure, and to treat or prevent intermittent claudication.
    Type: Application
    Filed: March 10, 2006
    Publication date: July 3, 2008
    Applicant: Aderis Pharmaceuticals, Inc.
    Inventors: Gevork Minaskanian, Keith Rippel
  • Patent number: 6372920
    Abstract: The present invention relates to a process for preparing optically active and racemic nitrogen-substituted 2-aminotetralins of the following Formula (I): wherein R1, R2, R3, R4, and n are set in the specification, wherein the process comprises alkylating the corresponding unsubstituted 2-aminotetralin of Formula (II): with a reactant of the Formula (III): Z—(CH2)n—R3  (III) wherein Z is a leaving group, in the presence of a base, wherein the base is selected from the group consisting of alkali metal carbonate and alkali metal bicarbonate, and wherein the amount of the base is less than about a 1.9-fold molar excess with respect to the amount of the 2-aminotetralin.
    Type: Grant
    Filed: November 16, 2000
    Date of Patent: April 16, 2002
    Assignee: Aderis Pharmaceuticals, Inc.
    Inventors: Gevork Minaskanian, Keith Rippel