Abstract: Provided herein are MAPT RNAi agents and compositions comprising a MAPT RNAi agent. Also provided herein are methods of using the MAPT RNAi agents or compositions comprising a MAPT RNAi agent for reducing MAPT expression and/or treating tauopathy in a subject.

Abstract: Devices, systems, and methods are directed to the use of vapor phase change in binder jetting processes for forming three-dimensional objects. In general, a vapor of a first fluid may be directed to a layer of a powder spread across a build volume. The vapor may condense to reduce mobility of the particles of the powder of the layer. For example, the condensing vapor may reduce the likelihood of particle ejection from the layer and, thus, may reduce the likelihood of clogging or otherwise degrading a printhead used to jet a second fluid (e.g., a binder) to the layer. Further, or instead, the condensing vapor may increase the density of the powder in the layer which, when repeated over a plurality of layers forming a three-dimensional object, may reduce the likelihood of slumping of the part during sintering.

Abstract: Devices, systems, and methods are directed to the use of vapor phase change in binder jetting processes for forming three-dimensional objects. In general, a vapor of a first fluid may be directed to a layer of a powder spread across a build volume. The vapor may condense to reduce mobility of the particles of the powder of the layer. For example, the condensing vapor may reduce the likelihood of particle ejection from the layer and, thus, may reduce the likelihood of clogging or otherwise degrading a printhead used to jet a second fluid (e.g., a binder) to the layer. Further, or instead, the condensing vapor may increase the density of the powder in the layer which, when repeated over a plurality of layers forming a three-dimensional object, may reduce the likelihood of slumping of the part during sintering.

Abstract: Devices, systems, and methods are directed to the use of vapor phase change in binder jetting processes for forming three-dimensional objects. In general, a vapor of a first fluid may be directed to a layer of a powder spread across a build volume. The vapor may condense to reduce mobility of the particles of the powder of the layer. For example, the condensing vapor may reduce the likelihood of particle ejection from the layer and, thus, may reduce the likelihood of clogging or otherwise degrading a printhead used to jet a second fluid (e.g., a binder) to the layer. Further, or instead, the condensing vapor may increase the density of the powder in the layer which, when repeated over a plurality of layers forming a three-dimensional object, may reduce the likelihood of slumping of the part during sintering.

Abstract: Devices, systems, and methods are directed to the use of vapor phase change in binder jetting processes for forming three-dimensional objects. In general, a vapor of a first fluid may be directed to a layer of a powder spread across a build volume. The vapor may condense to reduce mobility of the particles of the powder of the layer. For example, the condensing vapor may reduce the likelihood of particle ejection from the layer and, thus, may reduce the likelihood of clogging or otherwise degrading a printhead used to jet a second fluid (e.g., a binder) to the layer. Further, or instead, the condensing vapor may increase the density of the powder in the layer which, when repeated over a plurality of layers forming a three-dimensional object, may reduce the likelihood of slumping of the part during sintering.

Abstract: Devices, systems, and methods are directed to the use of vapor phase change in binder jetting processes for forming three-dimensional objects. In general, a vapor of a first fluid may be directed to a layer of a powder spread across a build volume. The vapor may condense to reduce mobility of the particles of the powder of the layer. For example, the condensing vapor may reduce the likelihood of particle ejection from the layer and, thus, may reduce the likelihood of clogging or otherwise degrading a printhead used to jet a second fluid (e.g., a binder) to the layer. Further, or instead, the condensing vapor may increase the density of the powder in the layer which, when repeated over a plurality of layers forming a three-dimensional object, may reduce the likelihood of slumping of the part during sintering.

Abstract: Devices, systems, and methods are directed to the use of vapor phase change in binder jetting processes for forming three-dimensional objects. In general, a vapor of a first fluid may be directed to a layer of a powder spread across a build volume. The vapor may condense to reduce mobility of the particles of the powder of the layer. For example, the condensing vapor may reduce the likelihood of particle ejection from the layer and, thus, may reduce the likelihood of clogging or otherwise degrading a printhead used to jet a second fluid (e.g., a binder) to the layer. Further, or instead, the condensing vapor may increase the density of the powder in the layer which, when repeated over a plurality of layers forming a three-dimensional object, may reduce the likelihood of slumping of the part during sintering.

Abstract: Devices, systems, and methods are directed to the use of vapor phase change in binder jetting processes for forming three-dimensional objects. In general, a vapor of a first fluid may be directed to a layer of a powder spread across a build volume. The vapor may condense to reduce mobility of the particles of the powder of the layer. For example, the condensing vapor may reduce the likelihood of particle ejection from the layer and, thus, may reduce the likelihood of clogging or otherwise degrading a printhead used to jet a second fluid (e.g., a binder) to the layer. Further, or instead, the condensing vapor may increase the density of the powder in the layer which, when repeated over a plurality of layers forming a three-dimensional object, may reduce the likelihood of slumping of the part during sintering.

Abstract: Devices, systems, and methods are directed to the use of vapor phase change in binder jetting processes for forming three-dimensional objects. In general, a vapor of a first fluid may be directed to a layer of a powder spread across a build volume. The vapor may condense to reduce mobility of the particles of the powder of the layer. For example, the condensing vapor may reduce the likelihood of particle ejection from the layer and, thus, may reduce the likelihood of clogging or otherwise degrading a printhead used to jet a second fluid (e.g., a binder) to the layer. Further, or instead, the condensing vapor may increase the density of the powder in the layer which, when repeated over a plurality of layers forming a three-dimensional object, may reduce the likelihood of slumping of the part during sintering.

Abstract: An adapter is configured to hold a loose tube fiber cable and is mountable into a fusion splicer. The adapter includes a clamp base having a first and second grooves, each groove having a centerline, a width and a depth. The depth of the second groove is greater than the depth of the first groove, such that a shoulder is formed between the first and second grooves. The centerlines of the grooves align. This allows for the loose tube fiber cable or splice-on connector to be properly positioned within the grooves. The first groove is V-shaped. The second groove may be V-shaped, U-shaped or square-shaped. A clamp cover seats on the clamp base. The clamp cover has a compressible pad which, when the clamp cover is placed into a facing relationship with the clamp base, the pad aligns with the first groove.

Abstract: An adapter is configured to hold a loose tube fiber cable and is mountable into a fusion splicer. The adapter includes a clamp base having a first and second grooves, each groove having a centerline, a width and a depth. The depth of the second groove is greater than the depth of the first groove, such that a shoulder is formed between the first and second grooves. The centerlines of the grooves align. This allows for the loose tube fiber cable or splice-on connector to be properly positioned within the grooves. The first groove is V-shaped. The second groove may be V-shaped, U-shaped or square-shaped. A clamp cover seats on the clamp base. The clamp cover has a compressible pad which, when the clamp cover is placed into a facing relationship with the clamp base, the pad aligns with the first groove.

Abstract: The EasyUp! is a convenience, safety rehabilitation and medical supply tool for use in the home, elder care, rehabilitation center, hospital or wherever anyone may need assistance in arising from a lying-down to seated, or from seated to a standing position due to injury or illness that may impact either strength or balance. The EasyUp! also assists a person to seat themselves or lie down. The tool clamps to most heavy “non-rocking” upholstered chairs, couches and beds to provide a stable hand grip that allows an individual to use upper body strength to assist the legs or back and to provide balance as they re-position their body.

Abstract: The KnuckleSaver Binder Release is a safety tool that releases lever-type chain binders with reduced impact danger to the operator. Essentially a J-hook with handles, the operator engages the hook to the handle of the lever-binder and pulls which releases the tension on the binder without dangerous “hands-on” contact with the binder.

Abstract: A fiber tray is provided for installing fiber optic cable and other types of cable that are vulnerable to performance losses if a certain minimum bend radius is not maintained. The fiber tray allows a user to create a subassembly that maintains bend radius control while easing assembly. The construction of the fiber tray also minimizes the depth of the tray and gives freedom to the user to vary the routing patterns of the cable so that a component that is attached to the end of the cable can be located at a predetermined spot on the tray.

Abstract: A fiber tray is provided for installing fiber optic cable and other types of cable that are vulnerable to performance losses if a certain minimum bend radius is not maintained. The fiber tray allows a user to create a subassembly that maintains bend radius control while easing assembly. The construction of the fiber tray also minimizes the depth of the tray and gives freedom to the user to vary the routing patterns of the cable so that a component that is attached to the end of the cable can be located at a predetermined spot on the tray.

Abstract: A sensor insertion and removal apparatus for inserting and/or removing a sensor into/from a chamber having at least one sensor port. The apparatus has a port collar configured to connect near to or at the sensor port of the chamber and to allow the sensor to pass through the port collar into the chamber. One or more cables or screws are attached to the sensor and utilized to insert and remove the sensor at a predefined rate into the chamber.

Abstract: A sensor insertion and removal apparatus for inserting and/or removing a sensor into/from a chamber having at least one sensor port. The apparatus has a port collar configured to connect near to or at the sensor port of the chamber and to allow the sensor to pass through the port collar into the chamber. One or more cables or screws are attached to the sensor and utilized to insert and remove the sensor at a predefined rate into the chamber.

Abstract: An apparatus for permanently or semi-permanently fitting to an underground water pipe 15,16 for detecting leaks therein, comprises a hydrophone 26 mounted to acoustically monitor water flowing along the pipe 15,16 and means 29 for analysing a parameter of the output signal of the hydrophone 26 and for generating an alarm signal, in the event that the parameter is above a maximum value or below a minimum value. The apparatus further comprises a radio transmitter for transmitting the alarm signal to a remote receiver, so as to indicate the detection of a leak. The maximum and minimum values are preferably calculated using historical data obtained from the hydrophone 26, so that the values are automatically adjusted to suit location of the apparatus. In use, a plurality of leak detection apparatus can be installed to pipes at various locations around a geographical area of supply.

Abstract: A base station antenna arrangement comprising a plurality of antenna arrays each capable of forming a multiplicity of separate overlapping narrow beams in azimuth, the arrays being positioned such that the totality of beams formed by the arrays provides a substantially omni-directional coverage in azimuth, azimuth and elevation beamforming means for each array, a plurality of r.f. transceivers each for transmitting and receiving r.f. signals for one or more calls, switching matrix means for connecting each transceiver with one or other of the arrays via the beamforming means, control means for controlling the switching matrix means whereby a particular transceiver is connected to a particular array via the beamforming means to exchange r.f. signals with a remote station located in the area covered by one of the narrow beams.

Abstract: An actuator assembly comprises a piston within an actuating cylinder, and a valve for controlling the flow of actuating fluid to the first side of the piston. When the valve is actuated the flow of fluid to the first side of the piston is stopped and the pressure of the actuating fluid on the piston is sufficient to maintain the piston in a predetermined position along the stroke path. Also disclosed is a method of actuating the crust breaker of a smelter pot using the apparatus described. Fluid leakage through the piston rod sealing assembly is reduced; the volume of compressed air used by the smelter is reduced; and the working life of the actuator is improved.