Abstract: Use of a benzodiazepine of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or preventing a hepatitis C infection, wherein: —R1 represents C1-6 alkyl, aryl or heteroaryl; —R2 represents hydrogen or C1-6 alkyl; —each R3 is the same or different and represents halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 haloalkyl, C1-6 haloalkoxy, amino, mono(C1-6 alkyl)amino, di(C1-6 alkyl)amino, nitro, cyano, —CO2R?, —CONR?R?, —NH—CO—R?, —S(O)R?, —S(O)2R?, —NH—S(O)2R?, —S(O)NR?R? or —S(O)2NR?R?, wherein each R? and R? is the same or different and represents hydrogen or C1-6 alkyl; —n is from 0 to 3; —R4 represents hydrogen or C1-6 alkyl; —R5 represents C1-6alkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)-, heterocyclyl-(C1-6 alkyl)-, aryl-(C1-6 hydroxyalkyl)-, heteroaryl-(C1-6hydroxyalkyl)-, carbocyclyl-(C1-6 hydroxyalkyl)-, heterocyclyl-(C1-6hydroxyalkyl)-, aryl-C(O)—

Abstract: An animal protectant power line electrical insulator to be placed on structures such as electrical apparatus to protect birds, wildlife and other animals. Specifically the insulator may include, a snap-fit insulating cover configured to fit over an energized part of an electrical structure of a power line, a resiliently flexible separable juncture for application onto the power line and secure closure; and perhaps even at least one formed eye on the cover. A cover may hold itself in place and may be made from plastic, fiberglass, PVC, or other semi-rigid, non-conductive material; molded, formed, or fabricated to fit a desired application.

Abstract: A contact tip used with the electrode of a resistance welder. The contact tip includes a bore that has an insert of blended tungsten and copper inserted therein. Prior to insertion of the insert into the bore, the bore is lined with a composition containing silver. A brazing process can be utilized to enhance attachment of the insert to the contact tip.

Abstract: A contact tip used with the electrode of a resistance welder. The contact tip includes a bore that has an insert of blended tungsten and copper inserted therein. Prior to insertion of the insert into the bore, the bore is lined with a composition containing silver. A brazing process can be utilized to enhance attachment of the insert to the contact tip.

Abstract: Use of a benzodiazepine of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for use in treating or preventing a hepatitis C infection, wherein: —R1 represents C1-6 alkyl, aryl or heteroaryl; —R2 represents hydrogen or C1-6 alkyl; —each R3 is the same or different and represents halogen, hydroxy, C1-6 alkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 haloalkyl, C1-6 haloalkoxy, amino, mono(C1-6 alkyl)amino, di(C1-6 alkyl)amino, nitro, cyano, —CO2R?, —CONR?R?, —NH—C0-R?, —S(O)R?, —S(O)2R?, —NH—S(O)2R?, —S(O)NR?R? or —S(O)2NR?R?, wherein each R? and R? is the same or different and represents hydrogen or C1-6 alkyl; —n is from 0 to 3; —R4 represents hydrogen or C1-6 alkyl; —R5 represents C1-6alkyl, aryl, heteroaryl, carbocyclyl, heterocyclyl, aryl-(C1-6 alkyl)-, heteroaryl-(C1-6 alkyl)-, carbocyclyl-(C1-6 alkyl)-, heterocyclyl-(C1-6 alkyl)-, aryl-(C1-6 hydroxyalkyl)-, heteroaryl-(C1-6hydroxyalkyl)-, carbocyclyl-(C1-6 hydroxyalkyl)-, heterocyclyl-(C1-6hydroxyalkyl)-, aryl-C(O)—

Abstract: An animal deterrent system to be placed on structures such as electrical apparatus to deter and protect birds, wildlife and other animals. Specifically, a perching deterrent having a saddle made to fit over any desired member of a structure and deterrent extensions may be used separately or in combination. The deterrent extensions may protrude in various configurations from the above-mentioned saddle to inhibit, deter, or insulate animals contracting structures. Also possible is an insulator cap with spiral conductor covers.

Abstract: An animal deterrent system to be placed on structures such as electrical apparatus to deter and protect birds, wildlife and other animals. Specifically, a perching deterrent having a saddle made to fit over any desired member of a structure and deterrent extensions may be used separately or in combination. The deterrent extensions may protrude in various configurations from the above-mentioned saddle to inhibit, deter, or insulate animals contacting structures. Also possible is an insulator cap with spiral conductor covers.

Abstract: The present invention provides compounds of Formula I, including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Abstract: The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I: Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Abstract: A welding system for performing a welding process on a pipe in a confined space includes a motor housing, a weld head assembly and an insertion tube that extends between the motor housing and the weld head assembly with the weld head assembly remote from the motor housing. The motor housing is supported on a platform for rotational and translational movement of the weld head assembly and houses a motor for positioning the weld head assembly relative to the pipe. The weld head assembly includes a clamp assembly for attaching the weld head assembly to the pipe and a weld tool assembly mounted adjacent the clamp assembly for welding the pipe. An arc length gear and a travel gear adjust the distance between a torch assembly and the pipe and adjust the location of the torch assembly around the pipe when the weld head assembly is attached to the pipe.

Abstract: A surface wave radar system including a receive antenna array (20, 22) for generating receive signals, and a data processing system (24) for processing received data representing the receive signals to mitigate ionospheric clutter. The received data is range and Doppler processed, and a spatial adaptive filter (52) is trained using training data selected from the processed data. The training data includes ionospheric clutter data and excludes cells which contain target data and substantial sea clutter. The processed data is filtered using the filter (52), which may be based on loaded sample matrix inversion. The antenna array (20,22) may be two-dimensional having an L or T shape.

Abstract: A pipette tip member has an elongated tubular receptacle including a sidewall with a plurality of stabilizing projections extending from the sidewall for aligning the pipette shaft, and a sidewall with a bifurcated section that includes first, second, and third sidewall portions. The first sidewall portion defines a base wall and the second and third sidewall portions branch therefrom. The second sidewall portion is an outside branch wall, and the third sidewall portion is an inside branch wall spaced substantially parallel with and radially inward from the second sidewall portion. The inside branch wall is flexible in the radial direction and engages a pipette shaft when it is inserted into the receptacle and to form a fluid-tight seal therewith. A method of forming a pipette tip member is also enclosed.

Abstract: Compounds of structural formula (I) are modulators of the androgen receptor (AR) in a tissue selective manner. They are useful as agonists of the androgen receptor in bone and/or muscle tissue while antagonizing the AR in the prostate of a male patient or in the uterus of a female patient.

Abstract: A pipette tip member having an elongated tubular receptacle having a sidewall with a bifurcated section that comprises first, second, and third sidewall portions. The first sidewall portion comprises a base wall and the second and third sidewall portions branch therefrom. The second sidewall portion comprises an outside branch wall, and the third sidewall portion comprises an inside branch wall spaced substantially parallel with and radially inward from the second sidewall portion. The inside branch wall is flexible in the radial direction and engages a pipette tip when it is inserted into the receptacle and to form a fluid-tight seal therewith. A method of forming a pipette tip member is also disclosed.

Abstract: The present invention provides compounds, including resolved enantiomers, diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula: A-L-CR where CR is a cyclical core group, L is a linking group and A is as defined herein. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

Abstract: The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.

Abstract: A pipette tip member having an elongated tubular receptacle having a sidewall having a plurality of stabilizing projections extending from the sidewall for aligning the pipette shaft and a sidewall with a bifurcated section that comprises first, second, and third sidewall portions. The first sidewall portion comprises a base wall and the second and third sidewall portions branch therefrom. The second sidewall portion comprises an outside branch wall, and the third sidewall portion comprises an inside branch wall spaced substantially parallel with and radially inward from the second sidewall portion. The inside branch wall is flexible in the radial direction and engages a pipette tip when it is inserted into the receptacle and to form a fluid-tight seal therewith. A method of forming a pipette tip member is also disclosed.

Abstract: A pipette tip member having an elongated tubular receptacle having a sidewall with a bifurcated section that comprises first, second, and third sidewall portions. The first sidewall portion comprises a base wall and the second and third sidewall portions branch therefrom. The second sidewall portion comprises an outside branch wall, and the third sidewall portion comprises an inside branch wall spaced substantially parallel with and radially inward from the second sidewall portion. The inside branch wall is flexible in the radial direction and engages a pipette tip when it is inserted into the receptacle and to form a fluid-tight seal therewith. A method of forming a pipette tip member is also disclosed.

Abstract: A surface wave radar system including a receive antenna array (20, 22) for generating receive signals, and a data processing system (24) for processing received data representing the receive signals to mitigate ionospheric clutter. The received data is range and Doppler processed, and a spatial adaptive filter (52) is trained using training data selected from the processed data. The training data includes ionospheric clutter data and excludes cells which contain target data and substantial sea clutter. The processed data is filtered using the filter (52), which may be based on loaded sample matrix inversion. The antenna array (20,22) may be two-dimensional having an L or T shape.