Abstract: Methods of administering Compound A, or pharmaceutically acceptable salt thereof, for the treatment of solid tumors having one or more genetic alterations in FGFR1, FGFR2 and/or FGFR3 are provided.

Abstract: Provided herein are new therapeutic regimens for treatment of cancer with a combination of a JAK inhibitor and an inhibitor targeting the MAPK pathway, combinations and methods of use thereof. In some embodiments, described herein are methods for treating cancer in an individual in need thereof, comprising administration of a JAK inhibitor and an inhibitor targeting the MAPK pathway to the individual. In some embodiments, the JAK inhibitor is a JAKI inhibitor.

Abstract: A boundary responsive wheel lock assembly for a supermarket shopping cart, or the like, or for any other application where a wheeled device is to be boundary responsive, is provided, to prevent the removal of the cart from an authorized area. The assembly includes a roller which is mounted on the distal end of an arm which, in turn, is pivotally mounted to a bracket to be positioned adjacent to one of the wheels of the cart. A spring-loaded plunger is also mounted on the bracket, and the plunger is normally held in a cocked position by the arm as the roller moves along the floor of the supermarket or along the surface of the adjacent parking lot. The parking lot is surrounded by a barrier which extends, for example, one and a half inches above the ground. However, the flexibility of the assembly of the invention enables the assembly to respond to a variety of boundary heights.