Abstract: The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

Abstract: The present invention relate to a method of rendering speed limit data on a vehicle speedometer (1). The vehicle speedometer (1) has a scale (3) and an indicator (5) for indicating the instantaneous speed of the vehicle. A set of speed limit data is received indicating an effective speed limit. A symbol (15) indicating the speed limit is displayed on the scale (3). The symbol (15) is positioned adjacent to a graduation mark (7) corresponding to the effective speed limit. The symbol (15) represents the road sign providing notification of the effective speed limit. The invention also relates a vehicle speedometer (1). Aspects of the Invention also relate to a computer system and a vehicle.

Abstract: An apparatus and method are provided that are operable to install data storage devices such as CDs and DVDs each into a respective carrier. The data storage devices are placed in respective recesses in the respective carriers by providing an open pocket into which the data storage devices may move under the influence of gravity when the data storage device is close to the recess within a respective carrier. A securement device is provided to secure the data storage device within a respective carrier recess.

Abstract: An apparatus and method are provided for producing an assembly comprising a plurality of digital data storage media carriers attached to a carrier strip. In the production of the assemblies, carriers are positioned for movement in a longitudinal direction of the conveyor system with the carriers being in a row. Carrier strips are secured to the carriers with the longitudinal axis of the assembly and the carrier strips being generally parallel to the direction of movement of the conveyor system. Carriers are deposited onto the conveyor system via a bottom feed depositor which depositor utilizes a pressure differential to help produce positive movement of carriers from a carrier magazine onto the conveyor.

Abstract: An apparatus and method are provided that are operable to install data storage devices such as CDs and DVDs each into a respective carrier. The data storage devices are placed in respective recesses in the respective carriers by providing an open pocket into which the data storage devices may move under the influence of gravity when the data storage device is close to the recess within a respective carrier. A securement device is provided to secure the data storage device within a respective carrier recess.

Abstract: An apparatus and method are provided for producing an assembly comprising a plurality of digital data storage media carriers attached to a carrier strip. In the production of the assemblies, carriers are positioned for movement in a longitudinal direction of the conveyor system with the carriers being in a row. Carrier strips are secured to the carriers with the longitudinal axis of the assembly and the carrier strips being generally parallel to the direction of movement of the conveyor system. Carriers are deposited onto the conveyor system via a bottom feed depositor which depositor utilizes a pressure differential to help produce positive movement of carriers from a carrier magazine onto the conveyor.