Patents by Inventor Keith W. MIKULE

Keith W. MIKULE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination therapies and uses thereof
    Patent number: 11801240
    Abstract: The present disclosure relates to combination therapies containing one or more PARP inhibitors and one or more angiogenesis inhibitor. Also described herein are therapeutic uses of such combination therapies for treating various disorders and conditions. The combination therapies and uses thereof can be useful for preventing tumor cell growth, preventing tumor metastasis, inducing an immune response or enhancing an immune response.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: October 31, 2023
    Assignee: Tesaro, Inc.
    Inventors: Keith W. Mikule, Zebin Wang, Yinghui Zhou
  • Combination therapies for treating cancer with niraparib and PD-1 inhibitors
    Patent number: 11661453
    Abstract: The present invention provides methods of treatment for cancer through combination therapy with an agent that inhibits programmed death-1 protein (PD-1) signaling and an agent that inhibits poly[ADP-ribose] polymerase (PARP) signaling.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: May 30, 2023
    Assignee: Tesaro, Inc.
    Inventors: Keith W. Mikule, Kaiming Sun, Jing Yu Wang, Zebin Wang
  • COMBINATION THERAPIES AND USES THEREOF
    Publication number: 20200306236
    Abstract: The present disclosure relates to combination therapies containing one or more PARP inhibitors and one or more angiogenesis inhibitor. Also described herein are therapeutic uses of such combination therapies for treating various disorders and conditions. The combination therapies and uses thereof can be useful for preventing tumor cell growth, preventing tumor metastasis, inducing an immune response or enhancing an immune response.
    Type: Application
    Filed: October 5, 2018
    Publication date: October 1, 2020
    Inventors: Keith W. Mikule, Zebin Wang, Yinghui Zhou
  • COMBINATION THERAPIES FOR TREATING CANCER
    Publication number: 20200299387
    Abstract: The present invention provides methods of treatment for cancer through combination therapy with an agent that inhibits programmed death-1 protein (PD-1) signaling and an agent that inhibits poly [ADP-ribose] polymerase (PARP) signaling.
    Type: Application
    Filed: September 28, 2018
    Publication date: September 24, 2020
    Applicant: Tesaro, Inc.
    Inventors: Keith W. MIKULE, Kaiming SUN, Jing Yu WANG, Zebin WANG